Antibacterial amide and sulfonamide substituted heterocyclic urea compounds

ABSTRACT

The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.

RELATED APPLICATIONS

This application is a 35 U.S.C. §371 national phase application of PCT/US2008/070893 (WO 2009/015208), filed on Jul. 23, 2008, entitled “Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds”, which application claims the benefit of U.S. Provisional Application Ser. No. 60/961,634, filed Jul. 23, 2007, and claims benefit of U.S. Provisional Application Ser. No. 61/022,725, filed Jan. 22, 2008, each of which is incorporated herein by reference in its entirety.

TECHNICAL FIELD

The present invention relates to novel heterocyclic urea compounds and in particular to novel amide and sulfonamide substituted heterocyclic urea compounds and to their uses in the treatment of bacterial infections.

BACKGROUND OF THE INVENTION

Antibacterials kill or inhibit the growth of bacteria by interfering with major processes of cellular function that are essential for survival. The development of antibacterial agents has significantly reduced the morbidity and mortality associated with bacterial infections over the last century, particularly in developed countries. However, the emergence of drug-resistant bacterial strains threatens the resurgence of bacterial-borne diseases long thought to have been conquered.

Resistance to antibacterials can occur when the target of a drug mutates so that it can still function, but is no longer inhibited by the drug (e.g., mutations in the quinolone resistance determining regions of bacterial gyrases and topisomerase enzymes that confer resistance to the fluoroquinolones). In a recent congressional report, the General Accounting Office (GAO) has summarized the current and future public health burden resulting from drug-resistant bacteria (Antimicrobial Resistance (1999). General Accounting Office (GAO/RCED-99-132)). According to this report, the number of patients treated in a hospital setting for an infection with drug-resistant bacteria has doubled from 1994 to 1996 and again almost doubled from 1996 to 1997. The same GAO report also provides clear evidence that previously susceptible bacteria are increasingly becoming resistant and spreading around the world. As a consequence of the increase and prevalence of resistant bacteria there is a growing need to identify new antibacterial agents.

SUMMARY OF THE INVENTION

It has now been found that amide and sulfonamide substituted heterocyclic urea compounds are useful in the treatment of bacterial infections. The present invention relates to these antibacterial compounds and salts thereof, pharmaceutical compositions comprising these compounds and methods of use thereof in the treatment of bacterial infections, including resistant bacterial infections.

In one aspect the invention provides compounds of Formula (I):

in which:

R₁ is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl;

X is selected from the group consisting of a C and N atom;

Y is selected from the group consisting of CO and SO₂;

R₂, R₃ and R₄ are independently selected from the group consisting of, H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl;

and further, optionally

wherein R₂, R₄, Y, and N together can form a substituted or unsubstituted 4-7 member saturated ring;

or alternatively, optionally

wherein R₂, R₃ and N together can form a substituted or unsubstituted 4-7 member saturated ring; and

R₅ is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R₅ is null when X is N.

These and various other features as well as advantages which characterize the invention will be apparent from a reading of the following detailed description and a review of the appended claims.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to antibacterial compounds and salts thereof, pharmaceutical compositions comprising these compounds and methods of use thereof. The compounds of the present invention are useful in the protection of patients from bacterial infections, including antibiotic resistant bacterial infections.

In particular, antibacterial compounds of the invention include amide and sulfonamide substituted heterocyclic urea compounds.

In one embodiment, the invention provides compounds of Formula (I):

In one embodiment, R₁ is preferably a substituted or unsubstituted phenyl or thiophene group, for example, a phenyl group which has one or more substituents independently selected from halogen, cyano, (C₁₋₆)alkyl, mono to perfluoro(C₁₋₃)alkyl, (C₃₋₇)cycloalkyl, (C₂₋₆)alkenyl, (C₁₋₆)alkoxy, (C₂₋₆)alkenoxy, hydroxy, amino, mono- or di-(C₁₋₆)alkylamino, acylamino, nitro, carboxy, (C₁₋₆)alkoxycarbonyl, (C₁₋₆)alkenyloxycarbonyl, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkyl, carboxy(C₁₋₆)alkyl, (C₁₋₆)alkylcarbonyloxy, carboxy(C₁₋₆)alkyloxy, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkoxy, (C₁₋₆)alkylthio, (C₁₋₆)alkylsulphinyl, (C₁₋₆)alkylsulphonyl, sulphamoyl, mono- and di-(C₁₋₆)-alkylsulphamoyl, and carbamoyl.

Suitable identities for R₁ include, but are not limited to, 3-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3-iodophenyl, 4-iodophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-4-methylendioxyphenyl, 3-4-difluorophenyl, 3-4-dichlorophenyl, 3-4-dibromophenyl, 3-4-dimethylphenyl, 3-4-(—CH₂CH₂CH₂—)phenyl, 3-4-(—OCH₂CH₂O—)phenyl, 3-chloro-4-fluorophenyl, benzo[1,3]dioxyl-5-yl, and 3-3-cyanophenyl, 3-5 difluorophenyl, thiophen-2-yl, thiophen-3-yl, 4,5-di-bromo-thiophen-2-yl, 5-chloro-thiophen-2-yl, and 5-bromo-thiophen-2-yl, 5-fluoro-thiophen-2-yl, 5-chloro-thiophen-3-yl, 1,1,-difluoro-benzo[1,3]dioxyl-5-yl, 7-chlorobenzo[1,3]dioxol-5-yl, 3-nitrophenyl, 2,1,3-benzoxadiazol-5-yl, and 4-nitrophenyl.

X is selected from the group consisting of C and N atom.

Y is selected from the group consisting of CO, and SO₂.

R₅ is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R₅ is null when X is N.

R₂, R₃ and R₄ are independently selected from the group consisting of, H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl.

Suitable identities for R₂, and R₃, include, but are not limited to, H, methyl, ethyl, 2-hydroxyethyl, 2-hydroxymethyl, 2,2-Difluoro-ethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, 2-methanesulfonylaminoethyl and 3,5-dimethylisoxazole-4-yl-methyl.

Suitable identities for R₄, include, but are not limited to methyl, 2-(2-methoxyethoxy)-methyl, 2-methoxymethyl, 4-methylisoxazole-5-yl, isoxazole-5-yl, 3-phenylpropanyl, furan-2-yl, 4-phenoxybutanyl, 1,1-dioxo-tetrahydro-1-lamda6-thiophen-3-ylmethylaminoyl, 3,5-dimethylisoxazole-4-yl, 1-methyl-1H-imidazole-5-yl, furan-3-yl, 3-methylfuran-2-yl, 5-methyl-3-phenylisoxazole-4-yl, 5-methyl-2-phenyl-2H-1,2,3-triazole-4-yl, 5-methylisoxazole-3-yl, 3-methyl-5-phenylisoxazole-4-yl, 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-yl, 2-(2H-tetrazol-5-yl)methyl, benzofuran-2-yl, 1,2,5-oxadiazole-3-yl, (3,5-dimethylisoxazol-4-yl)-methyl, 3-methylisoxazole-4-yl, 5-methylisoxazole-4-yl, 5-cyclopropyl-isoxazole-4-yl, 2,6-dimethylphenyl, 5-(furan-2-yl)-isoxazole-3-yl, 2,5-dimethyloxazole-4-yl, 2-phenylthiazole-4-yl, 2-(thiophen-2-yl)thiazole-4-yl, 3-hydroxy-isoxazole-5-yl, 5-phenyl-1,3,4-oxadiazole-2-yl, 5-methylfuran-2-yl, 4-methyl-1,2,5-oxadiazole-3-yl, 4-methyl-2-(pyrazin-2-yl)thiazole-5-yl, 2,4-dimethoxy-phenyl, 4-methoxy-phenyl, 3,4-dimethoxy-phenyl, benzo[1,3]dioxole-5-yl, 3,4,5-trimethoxy-phenyl, 5-methyl-3-(trifluoromethyl)isoxazole-4-yl, pyridin-3-ylmethyl, 2,4-dimethylpyridine-3-yl, 2,4,6-trimethylphenyl, 5-(methoxymethyl)-3-methylisoxazole-4-yl, 2-methoxy-methyl, 2-methoxyformyl, 3-ethyl-5-methylisoxazole-4-yl, pyrimidine-5-yl, pyrazine-2-yl, 5-methylpyrazine-2-yl, furan-3-yl, 4-methyloxazole-5-yl, 2-tosylmethyl, 3-ethylcarboxy-5-methylisoxazole-4-yl, 3-carboxy-5-methylisoxazole-4-yl, 2-methylpyridine-3-yl, 4-methylpyridine-3-yl, 3-chloro-4-(methylsulfonyl)thiophene-2-yl, 4-methylthiazole-5-yl, 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-yl, 4-methyl-2-(methylthio)pyrimidine-5-yl, 2-methylprop-1-enyl, 2-methylphenyl, quinoxaline-2,3-methylpyridine-4-yl, 3-methylisoxazole-4-yl, 4-amino-pyrimidine-5-yl, 2-amino-4-methylpyrimidine-5-yl, 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-yl, 2,4,6-trimethylpyrimidine-5-yl, 3-methylpyrazine-2-yl, 4-Boc-amino-1-methyl-1H-imidazole-2-yl, 4-amino-1-methyl-1H-imidazole-2-yl, 4-acetamido-1-methyl-1H-imidazole-2-yl, 4,6-dimethylpyrimidine-5-yl, 3-(hydroxymethyl)-5-methylisoxazole-4-yl, 3-methylpyridine-2-yl, 2-amino-4,6-dimethylpyrimidine-5-yl, 2-methylimidazo[1,2-a]pyridine-3-yl, tetrahydrofuran-2-yl, 2-methoxypyridine-3-yl, tetrahydrofuran-3-yl, methoxyformyl, 2-chloropyridine-3-yl, 1,3,5-tetramethyl-1H-pyrazole-4-yl, (S)-tetrahydrofuran-2-yl, (R)-tetrahydrofuran-2-yl, 3-propoxypyridine-4-yl, N-Boc-morpholine-2-yl, morpholine-2-yl, pyridazine-4-yl, 3,5-dimethyl-1H-pyrazole-4-yl, pyridazine-3-yl, tetrahydro-2H-pyran-4-yl, 1,5-dimethyl-1H-pyrazole-4-yl, morpholine-3-yl, 4-methylpyrrolidine-3-yl, (S)-pyrrolidine-2-yl, 1,1-Dioxo-tetrahydro-1-lamda6-thiophene-3-yl, 4-methylphenyl, methyl, ethyl, propyl, butyl, cyclopropyl, and 1,1-Dioxo-1-isothiazolidin-2-yl, 2-methyl-5,6-dihydro-4H-pyran-3-yl, 2-methyl-5-morpholin-4-ylmethyl-furan-3-yl, 2-methyl-but-2-enyl, [1,2,3]thiadiazole-4-yl, 2-pyridin-3-yl-thiazole-4-yl, 2,5-dimethyl-2H-pyrazole-3-yl, 4-methyl-furazan-3-yl, 2-morpholin-4-ylmethyl-furan-3-yl, 1-methyl-pyrrolidine-2-yl, 1-methyl-1H-pyrrole-2-yl, 1,5-dimethyl-1H-[1,2,3]-triazole-4-yl, 5-fluoro-thiophene-2-yl, 4-methyl-pyrimidine-5-yl, 4-methyl-2-phenyl-pyrimidine-5-yl, 2-methylsulfanyl-nicotinyl, acetonitrile, 6-morpholin-4-yl-nicotinyl, 4-methyl-thiazole-5-yl, 3-methyl-1H-pyrazole-4-yl, 2,4-dimethyl-pyrimidine-5-yl, 2-methyl-[1,6]naphthyridine-3-yl, 6-(4-methoxy-phenyl)-pyridazine-3-yl, 2,6-bis-dimethylamino-pyrimidine-4-yl, 2,6-di-morpholin-4-yl-pyrimidine-4-yl, 3-pyridin-3-yl-acrylonitrile-2-yl, 2-methyl-[1,8]naphthyridine-3-yl, 2-dimethylamino-6-methyl-pyrimidine-4-yl, acetic acid 1-yl-ethyl ester, 1-ethyl-3-methyl-1H-pyrazole-4-yl, 2-methyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-hydroxy-ethyl, 1-ethyl-5-methyl-1H-pyrazole-4-yl, 5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-methyl-1H-indole-3-yl, 1-methyl-1H-indazole-3-yl, pyrazolo[1,5-a]pyridine-3-yl, 2-furan-2-yl-oxo, 5-oxo-pyrrolidine-2-yl, 4-methyl-pyridazine-3-yl, 5-methyl-pyridazine-4-yl, 3-amino-1H-pyrazole-4-yl, 3,6-dimethoxy-pyridazine-4-yl, 3,6-dichloro-pyridazine-4-yl, pyridine-3-yl, pyridine-2-yl, 1-methyl-1H-imidazole-4-yl, 1,2-dimethyl-1H-imidazole-4-yl, pyridin-3-yl-methyl, 3-chloro-6-methoxy-pyridazin-4-yl, 3,5-dimethyl-pyridazin-4-yl, 1-methyl-3-trifluoromethyl-1H-pyrazol-4-yl, 3-chloro-6-hydroxy-pyridazin-4-yl, 2-methyl-tetrahydrofuran-2-yl, 4-chloro-1-methyl-1H-pyrazol-3-yl, 5-chloro-1-methyl-1H-pyrazol-4-yl, 4-chloro-2-methyl-2H-pyrazol-3-yl, 4-chloro-1H-pyrazol-3-yl, 1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-3-yl, 2-methyl-5-sulfamoyl-phenyl, 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl, 1-phenyl-cyclobutyl, 3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl, 7-chloro-benzo[1,3]dioxol-5-yl, 6-[1,2,4]triazol-1-yl-pyridin-3-yl, 1-(2-methoxyethyl)-6-oxo-1,6-dihydropyridazin-3-yl, 2-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)methyl, 6-chloro-3-hydroxy-pyridazin-4-yl, 3-cyano-2-hydroxy-6-methyl-pyridin-4-yl, 1-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl, 4-oxo-3,4-dihydrophthalazin-1-yl, 4,6-dimethyl-2-oxo-2H-pyran-5-yl, 1-methyl-4-sulfamoyl-1H-pyrrol-2-yl, (5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl, 3,6-dimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidin-5-yl, 5-methyl-4-oxo-3,4-dihydrothieno[2,3-b]pyrimidin-6-yl, phenyl-difluoromethyl, 4-hydroxyl-1-carbamoyl-pyrrolidin-2-yl, 2-(1-morpholino)-pyridin-3-yl, 1-(3-fluorophenyl)-cyclobutyl, 1-methyl-5-trifluoromethyl-1H-pyrazol-4-yl, (S)-1-methoxyethyl, 3-methyl-5,6-dihydro-1,4-dioxin-2-yl, (R)-5-oxo-tetrahydrofuran-2-yl, 5-chloro-1,3-dimethyl-1H-pyraozol-4-yl, 2-methoxy-ethyl, 1-(2-hydroxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, (R)-1-methoxy-ethyl, 1-(2-methoxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, tetrahydro-2H-pyran-2-yl, 3,6-dimethylisoxazolo[5,4-b]pyridine-4-yl, 5-methoxy-tetrahydrofuran-2-yl, 1-(4-methoxybutyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(3-methoxypropyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(4-fluorophenyl)-cyclobutyl, 5-methyl-tetrahydrofuran-2-yl, 3-methyl-oxetan-3-yl, 5-chloro-1H-pyrazol-4-yl, (R)-2,2-dimethyl-1,3-dioxolan-4-yl, (S)-2,2-dimethyl-1,3-dioxolan-4-yl, 3,6-dichloro-5-methyl-pyridazin-4-yl, 6-methoxyl-3-methyl-pyridazin-4-yl, 1-methyl-5-nitro-1H pyrazol-4-yl, 2,3-dihydrobenzofuran-2-yl, 6-hydroxy-3-methyl-pyridazin-4-yl, 2-(1-pyrrolidinyl)-pyridin-3-yl, 3-oxo-3-(2-thiophenyl)-propyl, 3-oxo-3-phenyl-propyl, 3-fluoro-4-methoxy-benzyl, 3,4-dimethoxy-benzyl, 4-(hydroxymethyl)-phenoxy-methyl, 3-methylsulfonyl-benzyl, 2-mercapto-4-methyl-thiazol-5-yl, 5-trifluoromethyl-furan-2-yl, 6-hydroxy-3-methylamino-pyridazin-4-yl, 3-(dimethylamino)-6-methoxy-pyridazin-4-yl, 2,2-dimethyl-tetrahydro-2H-pyran-4-yl, 4-(dimethylamino)-benzyl, 7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl, 1H-benzoimidazol-2-yl, naphthalene-2-yl-methyl, 4-methoxy-3-methyl-benzyl, 1-amino-2-benzyloxy-ethyl, 1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl, 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-methyl, 5-nitro-1H-pyrazol-4-yl, (S)-3,3-difluoro-tetrahydrofuran-2-yl, chroman-2-yl, 3,5-dimethyl-1H-pyrazol-4-yl, 4-butynyl, 2-methyl-1,2,34-tetrahydroisoquinolin-3-yl, (S)-2-(4-pyridinyl), 1-amino-ethyl, cis-3-methoxy-tetrahydrofuran-2-yl, 1-cyano-cyclopropyl, ethynyl, 1-ethoxy-ethyl, 1-(4-methoxy-phenoxy)ethyl, 1-(cyclopropylmethoxy)ethyl, 1,4-diamino-butyl, 1-(2-phenoxyethoxy)ethyl, cyclopropylmethyl, 3-ethyl-3-oxetan-3-yl, 1-(2,2-difluoroethoxy)ethyl, 1-(4-fluoro-benzyloxy)ethyl, 1-(2,2,2-trifluoroethoxy)ethyl, 1-(prop-2-ynyloxy)ethyl, 5-methyl-isoxazol-3-yl, 1-((1-methyl-pyrrolidin-3-yl)oxy)ethyl, 1-(2-hydroxyethoxy)ethyl, cyclopentyl, 1-hydroxy-cyclopropyl, cyclohexyl, 2-methyl cyclohexyl, 2-oxo-2,3-dihydrobenzoxazol-6-yl, 2,2,2-trifluoroethyl, 1-hydroxy-1-methyl-ethyl, (R)-5-(hydroxymethyl)tetrahydrofuran-2-yl, (4-hydroxy-2-oxo-pyrrolidin-1-yl)methyl, 1,2,2,2-tetrafluoroethyl, 1-carbamoyl-cyclopropyl, 2-methyl-cyclopropyl, 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl, 5-isopropyl-3-methyl-isoxazol-4-yl, and 1,3,5-trimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl.

In alternative embodiments, R₂, R₄, Y, and N together form a substituted or unsubstituted 4-7 member saturated ring. Suitable identities for such a substituted or unsubstituted 4-7 member saturated rings include, but are not limited to, 2,4-dioxothiazolidin-3-yl and 2-oxooxazolidin-3-yl.

In other alternative embodiments, R₂, R₃ and N together form a substituted or unsubstituted 4-7 member saturated ring. Suitable identities for such a substituted or unsubstituted 4-7 member saturated rings include, but are not limited to, 4-acetoxy-1-(methylsulfonyl)pyrrolidin-2-yl and 4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl.

When used herein, the term “alkyl” and similar terms such as “alkoxy” include all straight chain, branched, and cyclic isomers. Representative examples thereof include methyl, ethyl, n-propyl, iso-propyl, cyclobutyl, cyclopropyl, cyclopentyl, cyclohexyl, n-butyl, sec-butyl, iso-butyl, t-butyl, n-pentyl and n-hexyl. Optionally fluorosubstituted alkyls may have 1 or more substitutions of F for H on the alkyl chain. A representative example of an optionally fluorosubstituted alkyl is trifluoromethyl.

When used herein, the terms “alkenyl” and “alkynyl” include all straight chain, branched and cyclic isomers. Representative examples thereof include vinyl, ethynyl and 1-propynyl. Optionally fluorosubstituted alkenyls may have 1 or more substitutions of F for H on the alkenyl chain. A representative example of an optionally fluorosubstituted alkenyl is fluorovinyl.

Preferred substituents for alkyl and alkenyl groups include, for example, and unless otherwise defined, halogen, cyano, azido, nitro, carboxy, (C₁₋₆)alkoxycarbonyl, carbamoyl, mono- or di-(C₁₋₆)alkylcarbamoyl, sulpho, sulphamoyl, mono- or di-(C₁₋₆)alkylsulphamoyl, amino, mono- or di-(C₁₋₆)alkylamino, acylamino (e.g., pyridyloxy), ureido, (C₁₋₆)alkoxycarbonylamino, 2,2,2-trichloroethoxycarbonylamino, aryl, heteroaryl, heterocyclyl, hydroxy, (C₁₋₆)alkoxy (e.g., ethoxy, isopropoxy), acyloxy (e.g., phenyloxy, benzyloxy, phenethoxy), oxo, acyl, 2-thienoyl, (C₁₋₆)alkylthio, (C₁₋₆)alkylsulphinyl, (C₁₋₆)alkylsulphonyl, hydroxyimino, (C₁₋₆)alkoxyimino, hydrazino, hydrazono, benzohydroximoyl, guanidino, amidino and iminoalkylamino Also preferred are 4-formyl-piperazin-1-yl, 4-methylpiperazin-1-yl-, 4-ethylpiperazin-1-yl-, 4-phenylpiperazin-1-yl-, 4-pyrimidin-2-yl-piperazin-1-yl, Hexahydroxy-pyrrolo[1,2-a]imidazole-1-yl, Morpholin-4-yl, 3-(2-methoxy-ethyl)-methyl-amino, and 3-(2-methoxy-ethyl)-methyl-amino. Other appropriate substituents include alkylthio meaning an alkyl-S— group in which the alkyl group is as previously described. Non-limiting examples of suitable alkylthio groups include methylthio and ethylthio. The bond to the parent moiety is through the sulfur. Substituents further include alkoxycarbonyl meaning an alkyl-O—CO— group. Non-limiting examples of suitable alkoxycarbonyl groups include methoxycarbonyl and ethoxycarbonyl. The bond to the parent moiety is through the carbonyl. Another suitable substituent is alkylsulfonyl meaning an alkyl-SO₂ group. Preferred alkylsulfonyl groups are those in which the alkyl group is a lower alkyl. The bond to the parent moiety is through the sulfonyl.

When used herein, the term “aryl” means an aromatic monocyclic or multicyclic ring system with each ring comprising from about 6 to about 14 carbon atoms, preferably about 6 to about 10 carbon atoms. The aryl group can be optionally substituted with one or more “ring system substituents” and optionally substituted with up to five, preferably up to three substituents which may be the same or different, and are as defined herein. Non-limiting examples of suitable aryl groups include phenyl, naphthyl, anthracenyl, phenanthrenyl, indanyl, indenyl, and the like. Aryl moieties are well known and described, for example, in Hawley's Condensed Chemical Dictionary (13 ed.), R. J. Lewis, ed., J. Wiley & Sons, Inc., New York (1997). Aryl groups can be substituted or unsubstituted.

When substituted, an aryl group may have up to three substituents. Preferred substituents for an aryl group (a “ring system substituent”) include, for example, and unless otherwise defined, halogen, cyano, (C₁₋₆)alkyl, mono to perfluoro(C₁₋₃)alkyl, (C₃₋₇)cycloalkyl, (C₂₋₆)alkenyl, (C₁₋₆)alkoxy, (C₂₋₆)alkenoxy, arylC₍₁₋₆₎alkoxy, halo(C₁₋₆)alkyl, hydroxy, amino, mono- or di-(C₁₋₆)alkylamino, acylamino, nitro, carboxy, (C₁₋₆)alkoxycarbonyl, (C₁₋₆)alkenyloxycarbonyl, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkyl, carboxy(C₁₋₆)alkyl, (C₁₋₆)alkylcarbonyloxy, carboxy(C₁₋₆)alkyloxy, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkoxy, (C₁₋₆)alkylthio, (C₁₋₆)alkylsulphinyl, (C₁₋₆)alkylsulphonyl, sulphamoyl, mono- and di-(C₁₋₆)-alkylsulphamoyl, carbamoyl, mono- and di-(C₁₋₆)alkylcarbamoyl, heteroaryl and heterocyclyl. Other preferred aryl groups include arylalkyl meaning an alkyl substituted aryl group. Other preferred aryl groups include aryloxy meaning an aryl-O— group in which the aryl group is as previously described. Non-limiting examples of suitable aryloxy groups include phenoxy and naphthoxy. The bond to the parent moiety is through the ether oxygen. Arylalkyloxy meaning an arylalkyl-O— group in which the arylalkyl group is as previously described. Non-limiting examples of suitable arylalkyloxy groups include benzyloxy and phenethyloxy. The bond to the parent moiety is through the ether oxygen. Another preferred aryl is an arylthio meaning an aryl-S— group in which the aryl group is as previously described. Non-limiting examples of suitable arylthio groups include phenylthio and naphthylthio. The bond to the parent moiety is through the sulfur. Other preferred aryls include arylalkylthio meaning an arylalkyl-S— group in which the arylalkyl group is as previously described. Non-limiting example of a suitable arylalkylthio group is benzylthio. The bond to the parent moiety is through the sulfur. Other preferred aryls is an aryloxycarbonyl meaning an aryl-O—C(O)— group. Non-limiting examples of suitable aryloxycarbonyl groups include phenoxycarbonyl and naphthoxycarbonyl. The bond to the parent moiety is through the carbonyl. Another such group is an arylalkoxycarbonyl meaning an arylalkyl-O—C(O)— group. Non-limiting example of a suitable arylkoxycarbonyl group is benzyloxycarbonyl. The bond to the parent moiety is through the carbonyl. Yet another such group is an arylsulfonyl meaning an aryl-SO₂— group. The bond to the parent moiety is through the sulfonyl.

When used herein, the term “heteroaryl” monocyclic and polycyclic aromatic hydrocarbons include at least one heteroatom ring member such as sulfur, oxygen, or nitrogen alone or in combination. Preferably the heteroaryl ring comprises from 4 to 7, and preferably 5 to 6, ring atoms. Non-limiting examples of suitable heteroaryls include pyridyl, pyrazinyl, furanyl, thienyl, pyrimidinyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, pyrazolyl, furazanyl, pyrrolyl, pyrazolyl, triazolyl, 1,2,4-thiadiazolyl, pyrazinyl, pyridazinyl, quinoxalinyl, phthalazinyl, imidazo[1,2-a]pyridinyl, imidazo[2,1-b]thiazolyl, benzofurazanyl, indolyl, azaindolyl, benzimidazolyl, benzothienyl, quinolinyl, imidazolyl, thienopyridyl, quinazolinyl, thienopyrimidyl, pyrrolopyridyl, imidazopyridyl, isoquinolinyl, benzoazaindolyl, 1,2,4-triazinyl, benzothiazolyl, triazinyl, furyl, quinolyl, isoquinolyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrryl, oxazolyl, benzofuryl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl indazolyl, 1,2,4-thiadiazolyl, isothiazolyl, benzothienyl, purinyl, carbazolyl, benzimidazolyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzothienyl-5-oxide, 2,3-dihydrobenzothienyl-5-dioxide, benzoxazolin-2-on-yl, indolinyl, benzodioxolanyl, benzodioxane, and the like. Heteroaryl groups can be substituted or unsubstituted. A fused heteroaryl ring system may include carbocyclic rings and need only include one heterocyclic ring.

When used herein, the term “heterocyclyl” means an aromatic or non-aromatic saturated monocyclic or multicyclic (preferably bicyclic) ring system comprising about 3 to about 10 ring atoms, preferably about 5 to about 10 ring atoms, in which one or more of the atoms in the ring system is an element other than carbon, for example nitrogen, oxygen or sulfur, alone or in combination. Suitably the heterocyclic ring comprises from 4 to 7, preferably 5 to 6, ring atoms. A fused heterocyclic ring system may include carbocyclic rings and need only include one heterocyclic ring. There are no adjacent oxygen and/or sulfur atoms present in the ring system. Preferred heterocyclyls contain about 5 to about 6 ring atoms. The prefix aza, oxa or thia before the heterocyclyl root name means that at least a nitrogen, oxygen or sulfur atom respectively is present as a ring atom. Any —NH in a heterocyclyl ring may exist protected such as, for example, as an —N(Boc), —N(CBz), —N(Tos) group and the like; such protected moieties are also considered part of this invention. The heterocyclyl can be optionally substituted by one or more “ring system substituents” which may be the same or different, and are as defined herein. The nitrogen or sulfur atom of the heterocyclyl can be optionally oxidized to the corresponding N-oxide, S-oxide or S,S-dioxide. Non-limiting examples of suitable monocyclic heterocyclyl rings include piperidyl, pyrrolidinyl, piperazinyl, morpholinyl, thiomorpholinyl, thiazolidinyl, 1,4-dioxanyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrimidyl, oxazolidinyl, and the like.

When substituted, a heteroaryl or a heterocyclyl group may have up to three substituents. Preferred such substituents include those previously mentioned for an aryl group as well as oxo.

When used herein, the terms “halogen” and “halo” include fluorine, chlorine, bromine and iodine and fluoro, chloro, bromo and iodo, respectively.

When used herein, the term “acyl” means an H—C(O)—, alkyl-C(O)— or cycloalkyl-C(O)—, group in which the various groups are as previously described. The bond to the parent moiety is through the carbonyl. Preferred acyls contain a lower alkyl. Non-limiting examples of suitable acyl groups include formyl, acetyl and propanoyl.

When used herein, the term “substituted” means that one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency under the existing circumstances is not exceeded, and that the substitution results in a stable compound. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. By “stable compound” or “stable structure” is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. The term “optionally substituted” means optional substitution with the specified groups, radicals or moieties.

It should also be noted that any heteroatom with unsatisfied valences in the text, schemes, examples and Tables herein is assumed to have the hydrogen atom to satisfy the valences. When a functional group in a compound is termed “protected”, this means that the group is in modified form to preclude undesired side reactions at the protected site when the compound is subjected to a reaction. Suitable protecting groups will be recognized by those with ordinary skill in the art as well as by reference to standard textbooks such as, for example, T. W. Greene et al, Protective Groups in Organic Synthesis (1991), Wiley, N.Y.

When any variable (e.g., aryl, heterocycle, R₂, etc.) occurs more than one time in any constituent or in Formula (I), its definition on each occurrence is independent of its definition at every other occurrence.

When used herein, the term “composition” is intended to encompass a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from combination of the specified ingredients in the specified amounts.

The compounds according to the invention are suitably provided in substantially pure form, for example at least 50% pure, suitably at least 60% pure, advantageously at least 75% pure, preferably at least 85% pure, more preferably at least 95% pure, especially at least 98% pure, all percentages being calculated as weight/weight. An impure or less pure form of a compound according to the invention may, for example, be used in the preparation of a more pure form of the same compound or of a related compound (for example a corresponding derivative) suitable for pharmaceutical use.

It will be appreciated that certain compounds of the present invention may comprise one or more chiral centers so that compounds may exist as stereoisomers, including diastereoisomers and enantiomers. The present invention covers all such stereoisomers, and mixtures thereof, including racemates.

In some aspects of the present invention provides compounds of Formula (Ia):

in which:

R₁, R₂, R₃, R₄, R₅ and X are as previously described herein.

In addition, aspects of the present invention provide compounds of Formula (Ib):

in which:

R₁, R₂, R₃, R₄, R₅ and X are as previously described herein.

Accordingly, the invention provides the following compounds:

-   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)acetamide; -   3-(N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)acetamido)propylphosphonic     acid; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-methoxyethoxy)-N-methylacetamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylisoxazole-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-phenylpropanamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-2-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-phenoxybutanamide; -   1-(3,4-Dichloro-benzyl)-3-{4-[3-(1,1-dioxo-tetrahydro-116-thiophen-3-ylmethyl)-1-methyl-ureidomethyl]-thiazol-2-yl}-urea; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylfuran-2-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-phenylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-ethyl-3,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-isopropyl-3,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-phenylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2H-tetrazol-5-yl)acetamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzofuran-2-carboxamide; -   N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)ethyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,2,5-oxadiazole-3-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(3,5-dimethylisoxazol-4-yl)-N-methylacetamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-ethyl-N,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; -   5-cyclopropyl-N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,6-trimethylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(furan-2-yl)-N-methylisoxazole-3-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,5-trimethyloxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylthiazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2,4-dimethoxybenzyl)-3,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)-3,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(thiophen-2-yl)thiazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylisoxazole-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-phenyl-1,3,4-oxadiazole-2-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylfuran-2-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-1,2,5-oxadiazole-3-carboxamide; -   4-Methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid     {2-[3-(3,4-dichlorobenzyl)ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2,4-dimethoxy-N-methylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-4-methoxy-N-methylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4-dimethoxy-N-methylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4,5-trimethoxy-N-methylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-(trifluoromethyl)isoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyridin-3-yl)acetamide; -   N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-(methylamino)-2-oxoethyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylbenzamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide; -   methyl     2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)amino)-2-oxoacetate; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide; -   3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyrazine-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyloxazole-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-tosylacetamide; -   Ethyl     4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylate; -   4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylic     acid; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylnicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylnicotinamide; -   3-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-(methylsulfonyl)thiophene-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylthiazole-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-2-(methylthio)pyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylbut-2-enamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylbenzamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylquinoxaline-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpicolinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-((4-methoxybenzyloxy)methyl)-N,3-dimethylisoxazole-4-carboxamide; -   N-(2-Aminoethyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethylisoxazole-4-carboxamide; -   4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; -   2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethyl-N-(2-(methylsulfonamido)ethyl)isoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylpyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; -   tert-butyl     2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-1-methyl-1H-imidazol-4-ylcarbamate; -   4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide; -   4-acetamido-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-(hydroxymethyl)-N,5-dimethylisoxazole-4-carboxamide; -   N-((2-(3-(4-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide; -   N-((2-(3-(3-chlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(benzo[1,3]dioxol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide; -   N-((2-(3-(2,2-difluorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylimidazo[1,2-a]pyridine-3-carboxamide; -   N,3,5-trimethyl-N-((2-(3-(3-(N-methylacetamido)benzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   1-(4-((2,4-dioxothiazolidin-3-yl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylnicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-3-carboxamide; -   N,3,5-trimethyl-N-((2-(3-(thiophen-3-ylmethyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; -   methyl     (2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl(2-hydroxyethyl)carbamate; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3-methylisonicotinamide; -   1-(3-fluorobenzyl)-3-(4-((2-oxooxazolidin-3-yl)methyl)thiazol-2-yl)urea; -   2-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylnicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,5-tetramethyl-1H-pyrazole-4-carboxamide; -   (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-propoxypicolinamide; -   tert-butyl     2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)morpholine-4-carboxylate; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-2-carboxamide; -   N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; -   N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,5-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-((5-chlorofuran-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrrolidine-3-carboxamide; -   (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrrolidine-2-carboxamide; -   2-Methyl-5,6-dihydro-4H-pyran-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Methyl-5-morpholin-4-ylmethyl-furan-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Methyl-but-2-enoic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,2,3-Thiadiazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Pyridin-3-yl-thiazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2,5-Dimethyl-2H-pyrazole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Methyl-furazan-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Morpholin-4-ylmethyl-furan-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Methyl-pyrrolidine-2-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Methyl-1H-pyrrole-2-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,5-Dimethyl-1H-[1,2,3]triazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5-Fluoro-thiophene-2-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Methyl-pyrimidine-5-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Methyl-2-phenyl-pyrimidine-5-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-2-methylsulfanyl-nicotinamide; -   2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-morpholin-4-yl-nicotinamide; -   4-Methyl-thiazole-5-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2,4-Dimethyl-pyrimidine-5-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Methyl-[1,6]naphthyridine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   6-(4-Methoxy-phenyl)-pyridazine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-pyrazine-2-carboxylic acid     {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-pyrazine-2-carboxylic acid     {5-chloro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2,6-Bis-dimethylamino-pyrimidine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-3-pyridin-3-yl-acrylamide; -   2-Methyl-[1,8]naphthyridine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Dimethylamino-6-methyl-pyrimidine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-methoxy-N-methyl-2-phenyl-acetamide; -   3-Methyl-pyrazine-2-carboxylic acid     {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-pyrazine-2-carboxylic acid     methyl-[2-(3-thiophen-3-ylmethyl-ureido)-thiazol-4-ylmethyl]-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     {5-cyano-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Acetic acid     1-({2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-carbamoyl)-ethyl     ester; -   1-Ethyl-3-methyl-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Methyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-hydroxy-N-methyl-propionamide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-ethyl)-amide; -   1-Ethyl-5-methyl-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5,7-Dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-2-hydroxy-ethyl)-amide; -   1-Methyl-1H-indole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Methyl-1H-indazole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Pyrazolo[1,5-a]pyridine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-furan-2-yl-N-methyl-2-oxo-acetamide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     [2-(3-benzyl-ureido)-thiazol-4-ylmethyl]-methyl-amide; -   3-Methyl-pyrazine-2-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-5-isopropyl-thiazol-4-ylmethyl}-methyl-amide; -   5-Oxo-pyrrolidine-2-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-pyrazine-2-carboxylic acid     {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     (2,2-difluoro-ethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-amide; -   4-Methyl-pyridazine-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5-Methyl-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Amino-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,6-Dimethoxy-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   (3,5-Dimethyl-isoxazol-4-ylmethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-carbamic     acid methyl ester; -   (R)-Tetrahydro-furan-2-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5-Methyl-pyridazine-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5-Methyl-pyridazine-4-carboxylic acid     {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Tetrahydro-furan-2-carboxylic acid     {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,6-Dichloro-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Chloro-6-methoxy-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   (R)-Tetrahydro-furan-2-carboxylic acid     {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{5-Fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide; -   1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid     {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Chloro-6-hydroxy-pyridazine-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   2-Methyl-tetrahydro-furan-2-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   4-Chloro-1H-pyrazole-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3,5-Dimethyl-isoxazole-4-carboxylic acid     (cyano-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-methyl)-methyl-amide; -   1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,3,6-Trimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; -   1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Phenyl-cyclobutanecarboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   7-Chloro-benzo[1,3]dioxole-5-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; -   1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid     {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-methylacetamide; -   1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid     {2-[3-(5-chlorothiophen-2-yl)methyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylpyridazine-4-carboxamide; -   5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-isopropyl-N,3-dimethylisoxazole-4-carboxamide; -   3-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,6-dimethylisonicotinamide; -   6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-5-sulfamoylbenzamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1-phenylcyclobutanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide; -   7-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide; -   2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; -   2,2-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylacetamide; -   N2-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methylacetamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-(3-fluorophenyl)-N-methylcyclobutanecarboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2,2-difluoro-N-methyl-2-phenylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide; -   (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5,6-dihydro-1,4-dioxine-2-carboxamide; -   (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxotetrahydrofuran-2-carboxamide; -   5-chloro-N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-hydroxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; -   (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-2-carboxamide; -   N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; -   N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-methoxy-N-methyltetrahydrofuran-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-methoxybutyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(3-methoxypropyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; -   N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methylcyclobutanecarboxamide; -   1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyltetrahydrofuran-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyloxetane-3-carboxamide; -   5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1H-pyrazole-4-carboxamide; -   (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide; -   (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide; -   N-(2-amino-1-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)ethyl)-N-methyltetrahydrofuran-2-carboxamide; -   (R)—N-((2-(3-((5-fluorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   3,6-dichloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N,3-dimethylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,6-tetramethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N,3-dimethylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-(thiophen-2-yl)butanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-phenylbutanamide; -   2-(3-fluoro-4-methoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   2-(3,4-dimethoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-(hydroxymethyl)phenoxy)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(3-(methylsulfonyl)phenyl)acetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-mercapto-4-methylthiazol-5-yl)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)furan-2-carboxamide; -   (R)—N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N-methyl-3-(methylamino)pyridazine-4-carboxamide; -   3-(dimethylamino)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N-methylpyridazine-4-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide; -   N-((2-(3-((1H-indol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(benzo[1,2,5]thiadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   2-(4-(dimethylamino)phenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-7-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; -   3-(1H-benzoimidazol-2-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(naphthalen-2-yl)acetamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxy-3-methylphenyl)-N-methylacetamide; -   2-amino-3-(benzyloxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-6-(1H-1,2,4-triazol-1-yl)nicotinamide; -   2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide; -   N2-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide; -   (S)-3,3-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylchroman-2-carboxamide; -   4-(3,5-dimethyl-1H-pyrazol-4-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpent-4-ynamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; -   (S)-2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-(pyridin-4-yl)propanamide; -   cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methyltetrahydrofuran-2-carboxamide; -   1-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropiolamide; -   N-((2-(3-((1H-indol-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((2-(3-(benzoxazol-6-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   2-ethoxy-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxyphenoxy)-N-methylpropanamide; -   2-(cyclopropylmethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   2,5-diamino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpentanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2-phenoxyethoxy)propanamide; -   2-cyclopropyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; -   N,3,5-trimethyl-N-((2-(3-(4-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; -   N,3,5-trimethyl-N-((2-(3-(3-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; -   3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyloxetane-3-carboxamide; -   2-(2,2-difluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-fluorobenzyloxy)propanamide; -   2-(2,2,2-trifluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(prop-2-ynyloxy)propanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-((5-methylisoxazol-3-yl)methoxy)propanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(1-methylpyrrolidin-3-yloxy)propanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-hydroxyethoxy)propanamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-hydroxy-N-methylcyclopropanecarboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide; -   1-cyano-N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclohexanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide; -   3,3,3-trifluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide; -   2,3-cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyltetrahydrofuran-2-carboxamide; -   (5R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(hydroxymethyl)-N-methyltetrahydrofuran-2-carboxamide; -   N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide; -   N-((2-(3-(5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide; -   (S)—N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide; -   (R)—N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   (R)—N-((2-(3-((7-chlorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; -   2,3,3,3-tetrafluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropane-1,1-dicarboxamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclopropanecarboxamide; -   (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide; -   N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; -   N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,2,6-trimethylbenzamide; -   N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylisonicotinamide; -   N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; -   1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   3,6-Dimethyl-isoxazolo[5,4-b]pyridine-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-acetamide; -   3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic     acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; -   1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methyl-acetamide; -   3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic     acid{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   (R)-Tetrahydro-furan-2-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-3-cyano-2-hydroxy-6,N-dimethyl-isonicotinamide; -   6-Chloro-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   7-Chloro-benzo[1,3]dioxole-5-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; -   1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,2-difluoro-N-methyl-2-phenyl-acetamide; -   (R)-Tetrahydro-furan-2-carboxylic acid     [5-(3-benzo[1,2,5]oxadiazol-5-ylmethyl-ureido)-[1,2,4]thiadiazol-3-ylmethyl]-methyl-amide; -   3,5-Dimethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   3,5-Dimethyl-pyridazine-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; -   1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide; -   1-Phenyl-cyclobutanecarboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   7-Chloro-benzo[1,3]dioxole-5-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Phenyl-cyclobutanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-phenyl-acetamide; -   1,1-Dioxo-tetrahydro-thiophene-3-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,3-Dihydro-benzofuran-2-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   (R)-Tetrahydro-furan-2-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,3-Dihydro-benzofuran-2-carboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   (R)—N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide; -   (R)—N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide; -   N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; -   N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide; -   2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyridin-2-yl-acetamide; -   1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-amide     2-({5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide); -   Cyclopentanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2-Methyl-cyclohexanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   Cyclohexanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Cyano-cyclopropanecarboxylic acid     {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   1-Hydroxy-cyclopropanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-hydroxy-2,N-dimethyl-propionamide; -   1-Cyano-cyclopropanecarboxylic acid     {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; -   N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-((S)-4-hydroxy-2-oxo-pyrrolidin-1-yl)-N-methyl-acetamide; -   1,1-Dioxo-tetrahydro-1,6-thiophene-3-sulfonic acid     {2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylbenzenesulfonamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide; -   N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropane-1-sulfonamide; -   5-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-1-(methylsulfonyl)pyrrolidin-3-yl     acetate; -   1-(3,4-dichlorobenzyl)-3-(4-(4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl)thiazol-2-yl)urea; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbutane-1-sulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylethanesulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanesulfonamide; -   N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-(methylsulfonamido)ethyl)methanesulfonamide; -   1-[4-(1,1-Dioxo-116-isothiazolidin-2-ylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea; -   1-(3-Fluoro-benzyl)-3-{4-[1-(propane-1-sulfonyl)-pyrrolidin-2-yl]-thiazol-2-yl}-urea; -   Ethanesulfonic acid     {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-4-morpholin-4-yl-benzenesulfonamide; -   Furan-2-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Thiophene-2-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Pyridine-3-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   Pyridine-2-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1-Methyl-1H-imidazole-4-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   1,2-Dimethyl-1H-imidazole-4-sulfonic acid     {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; -   N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-C-pyridin-3-yl-methanesulfonamide;     and -   N-(3,5-Dimethyl-isoxazol-4-ylmethyl)-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methanesulfonamide.

Prodrugs and solvates of the compounds of the invention are also contemplated herein. The term “prodrug”, as employed herein, denotes a compound that is a drug precursor which, upon administration to a subject, undergoes chemical conversion by metabolic or chemical processes to yield a compound of Formula (I) (note that Formula (I) includes Formula (Ia) and Formula (Ib)) or a salt and/or solvate thereof. A discussion of prodrugs is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems (1987) 14 of the A.C.S. Symposium Series, and in Bioreversible Carriers in Drug Design, (1987) Edward B. Roche, ed., American Pharmaceutical Association and Pergamon Press, both of which are incorporated herein by reference thereto.

When used herein, the term “solvate” means a physical association of a compound of this invention with one or more solvent molecules. This physical association involves varying degrees of ionic and covalent bonding, including hydrogen bonding. In certain instances the solvate will be capable of isolation, for example when one or more solvent molecules are incorporated in the crystal lattice of the crystalline solid. “Solvate” encompasses both solution-phase and isolatable solvates. Non-limiting examples of suitable solvates include ethanolates, methanolates, and the like.

When used herein, the term “hydrate” is a solvate wherein the solvent molecule is H₂O.

As used herein, the phrases “effective amount” or “therapeutically effective amount” are meant to describe an amount of compound or a composition of the present invention effective in inhibiting bacterial replication and thus producing the desired therapeutic, ameliorative, inhibitory or preventative effect.

The compounds of Formula (I) (as defined herein Formula (I) includes Formula (Ia) and (1b)) can form salts which are also within the scope of this invention. Reference to a compound of Formula (I) herein is understood to include reference to salts thereof, unless otherwise indicated. The term “salt(s)”, as employed herein, denotes acidic salts formed with inorganic and/or organic acids, as well as basic salts formed with inorganic and/or organic bases. In addition, when a compound of Formula (I) contains both a basic moiety, such as, but not limited to a pyridine or imidazole, and an acidic moiety, such as, but not limited to a carboxylic acid, zwitterions (“inner salts”) may be formed and are included within the term “salt(s)” as used herein. Pharmaceutically acceptable (i.e., non-toxic, physiologically acceptable) salts are preferred, although other salts are also useful. Salts of the compounds of the Formula (I) may be formed, for example, by reacting a compound of Formula (I) with an amount of acid or base, such as an equivalent amount, in a medium such as one in which the salt precipitates, or in an aqueous medium followed by lyophilization.

Exemplary acid addition salts include acetates, ascorbates, benzoates, benzenesulfonates, bisulfates, borates, butyrates, citrates, camphorates, camphorsulfonates, fumarates, hydrochlorides, hydrobromides, hydroiodides, lactates, maleates, methanesulfonates, naphthalenesulfonates, nitrates, oxalates, phosphates, propionates, salicylates, succinates, sulfates, tartarates, thiocyanates, toluenesulfonates (also known as tosylates,) and the like. Additionally, acids which are generally considered suitable for the formation of pharmaceutically useful salts from basic pharmaceutical compounds are discussed, for example, by S. Berge et al, Journal of Pharmaceutical Sciences (1977) 66(1) 1 19; P. Gould, International J. of Pharmaceutics (1986) 33 201 217; Anderson et al, The Practice of Medicinal Chemistry (1996), Academic Press, New York; and in The Orange Book (Food & Drug Administration, Washington, D.C. on their website). These disclosures are incorporated herein by reference thereto.

Exemplary basic salts include ammonium salts, alkali metal salts such as sodium, lithium, and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases (for example, organic amines) such as dicyclohexylamines, t-butyl amines, and salts with amino acids such as arginine, lysine and the like. Basic nitrogen-containing groups may be quarternized with agents such as lower alkyl halides (e.g. methyl, ethyl, and butyl chlorides, bromides and iodides), dialkyl sulfates (e.g. dimethyl, diethyl, and dibutyl sulfates), long chain halides (e.g. decyl, lauryl, and stearyl chlorides, bromides and iodides), arylalkyl halides (e.g. benzyl and phenethyl bromides), and others.

All such acid and base salts are intended to be pharmaceutically acceptable salts within the scope of the invention and all acid and base salts are considered equivalent to the free forms of the corresponding compounds for purposes of the invention.

Compounds of Formula (I) and salts, solvates and prodrugs thereof, may exist in their tautomeric form (for example, as an amide or imino ether). All such tautomeric forms are contemplated herein as part of the present invention. All stereoisomers (for example, geometric isomers, optical isomers and the like) of the present compounds (including those of the salts, solvates and prodrugs of the compounds as well as the salts and solvates of the prodrugs), such as those which may exist due to asymmetric carbons on various substituents, including enantiomeric forms (which may exist even in the absence of asymmetric carbons), rotameric forms, atropisomers, and diastereomeric forms, are contemplated within the scope of this invention, as are positional isomers (such as, for example, 4-pyridyl and 3-pyridyl). Individual stereoisomers of the compounds of the invention may, for example, be substantially free of other isomers, or may be admixed, for example, as racemates or with all other, or other selected, stereoisomers. The chiral centers of the present invention can have the S or R configuration as defined by the IUPAC 1974 Recommendations. The use of the terms “salt”, “solvate” “prodrug” and the like, is intended to equally apply to the salt, solvate and prodrug of enantiomers, stereoisomers, rotamers, tautomers, positional isomers, racemates or prodrugs of the inventive compounds.

Compounds of Formula (I) are inhibitors of PolC, a type II DNA Polymerase III, which is the major replicative polymerase responsible for chromosomal replication in low GC Gram-positive bacteria. Compounds of Formula (I) are generally selective for PolC, showing little or no inhibition of the eukaryotic replicative polymerase, i.e., provides an optimal combination of high activity against various pathogenic bacteria and low or no activity against mammalian calls, allowing the use of compounds of the invention in the treatment of mammals, and in particular humans.

Compounds of the present invention show antibacterial activity against clinically relevant Gram-positive pathogens, including S. pyogenes, S. aureus, S. pneumoniae and E. faecalis. Compounds of the present invention demonstrate preferential inhibition of DNA synthesis over RNA, protein, or cell wall synthesis in whole cell assays. Therapeutic compositions of the present invention have antibacterial activity against clinically important Gram-positive pathogens, including staphylococci and streptococci, and particularly including isolates resistant to currently marketed agents.

Another aspect of this invention is a method of protecting a patient from a bacterial infection. A patient may be an animal, preferably a mammal and even more preferably a human having or susceptible to a disease or condition associated with a bacterial infection. Protecting may be prophylactic, i.e., administering a compound of the present invention in the absence of a diagnosed bacterial infection, or therapeutic, i.e., administering a compound of the present invention upon diagnosis of a bacterial infection. Protection may be achieved by administering a therapeutically effective amount of at least one compound of Formula (I), or a pharmaceutically acceptable salt or solvate of said compound to the patient. A preferred dosage is about 0.001 to 500 mg/kg of body weight/day of the compound of Formula (I) or a pharmaceutically acceptable salt or solvate of said compound. An especially preferred dosage is about 0.01 to 25 mg/kg of body weight/day of a compound of Formula (I), or a pharmaceutically acceptable salt or solvate of said compound.

Methods to diagnose bacterial infection in patients are known in the art. Preferred bacterial infections to treat include bacterial infections caused by any bacteria type or species against which the compounds of the present invention have an antibacterial effect. Particularly preferred bacteria types or species include Gram-positive and Gram-negative bacteria and most preferred bacterial types include Gram-positive bacteria.

In order to protect an animal from bacterial infection, a therapeutic or prophylactic composition of the present invention is administered to the animal in an effective manner such that bacterial infection is minimized and/or reduced. Preferably, the bacterial infection and/or bacterial burden of the infectious bacteria is reduced by at least about 50%, at least about 70%, and more preferably at least about 90%, 95% or 97%.

Suitable patients to treat include humans; birds such as chickens, ostriches, quail, and turkeys; other mammals such as companion animals (including dogs, cats, and rodents) and economic food and/or fur or other product animals, such as horses, cattle, llamas, chinchillas, ferrets, goats, sheep, rodents, minks, rabbits, raccoons, and swine.

The compounds of this invention can also be useful in combination (administered together or sequentially) with one or more of antibacterial treatments, such as, for example, treatment with other known antibacterial drug classes such as, for example, β-lactams, glycopeptides, oxazolidinones, macrolides, ketolides, quinolones, fluoroquinolones, aminoglycosides, tetracyclines, and lipopeptides. If formulated as a fixed dose, such combination products employ the compounds of this invention within the dosage range described herein and the other pharmaceutically active agent or treatment within its dosage range. Compounds of Formula (I) may also be administered sequentially with known antibacterial agents when a combination formulation is inappropriate. The invention is not limited in the sequence of administration; compounds of Formula (I) may be administered either prior to or after administration of the known antibacterial agent. Such techniques are within the skills of persons skilled in the art as well as attending physicians.

Accordingly, in an aspect, this invention includes combinations comprising an amount of at least one compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, and an amount of one or more antibacterial agents or treatments listed above wherein the amounts of the compounds/treatments result in desired therapeutic effect. The pharmacological properties of the compounds of this invention may be confirmed by a number of pharmacological assays. The exemplified pharmacological assays which are described herein have been carried out with compounds according to the invention and/or their salts.

In another aspect, the invention includes pharmaceutical compositions which comprise at least one compound of Formula (I), or a pharmaceutically acceptable salt or solvate of said compound, and at least one pharmaceutically acceptable carrier. Accordingly, the present invention further includes compositions comprising one or more compounds of Formula (I) and a pharmaceutically acceptable carrier.

When used herein, the phrase “pharmaceutically acceptable carrier” refers to media generally accepted in the art for the delivery of biologically active agents to patients, in particular, mammals Pharmaceutically acceptable carriers are typically formulated according to a number of factors well within the purview of those of ordinary skill in the art. These include, without limitation: the type and nature of the active agent being formulated; the subject to which the agent-containing composition is to be administered; the intended route of administration of the composition; and, the therapeutic indication being targeted. Pharmaceutically acceptable carriers include both aqueous and non-aqueous liquid media, as well as a variety of solid and semi-solid dosage forms. Such carriers can include a number of different ingredients and additives in addition to the active agent, such additional ingredients being included in the formulation for a variety of reasons, e.g., stabilization of the active agent, binders, etc., well known to those of ordinary skill in the art. Descriptions of suitable pharmaceutically acceptable carriers, and factors involved in their selection, are found in a variety of readily available sources such as, for example, Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., 1985, which is incorporated herein by reference in its entirety.

Preparation of Pharmaceutical Compositions of the Invention Include inclusion of inert, solid or liquid pharmaceutically acceptable carriers. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets and suppositories. The powders and tablets may be comprised of from about 5 to about 95 percent active ingredient. Suitable solid carriers are known in the art, e.g., magnesium carbonate, magnesium stearate, talc, silica, sucrose, lactose, starch, or cellulose derivatives. Tablets, powders, cachets and capsules can be used as solid dosage forms suitable for oral administration. Examples of pharmaceutically acceptable carriers and methods of manufacture for various compositions may be found in A. Gennaro (ed.), Remington's Pharmaceutical Sciences, 18th Edition, (1990), Mack Publishing Co., Easton, Pa. incorporated herein by reference.

Liquid form preparations include solutions, suspensions and emulsions. As an example, water or water-propylene glycol solutions for parenteral injection or addition of sweeteners and opacifiers for oral solutions, suspensions and emulsions, can be used. Liquid form preparations may also include solutions for intranasal administration. Gelatin capsules can be used to contain the active ingredient and a suitable carrier such as, but not limited to, lactose, starch, magnesium stearate, steric acid, or cellulose derivatives. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of time. Compressed tablets can be sugar-coated or film-coated to mask any unpleasant taste, or used to protect the active ingredients from the atmosphere, or to allow selective disintegration of the tablet in the gastrointestinal tract. Liquid dose forms for oral administration can also contain coloring or flavoring agents to increase patient acceptance.

Typically, water, pharmaceutically acceptable oils, saline, aqueous dextrose, and related sugar solutions and glycols, such as propylene glycol or polyethylene glycol, are suitable carriers for parenteral solutions. Solutions for parenteral administration can contain, for example, a water soluble salt of the active ingredient and suitable stabilizing agent(s). Antioxidizing agents, such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or in combination, can act as suitable stabilizing agents. Also suitable as stabilizing agents are citric acid and its salts, and EDTA. In addition, parenteral solutions can contain preservatives such as, for example, benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol.

Oral compositions are preferred and will generally include an inert diluent or an edible carrier and may be compressed into tablets or enclosed in gelatin capsules. The oral dosage forms are administered to the patient weekly, twice weekly, three times weekly, four times weekly, five times weekly, six times weekly, or 1, 2, 3, or 4 times daily. It is preferred that the compounds of the invention be administered either three or fewer times daily, more preferably once or twice daily. For purposes of oral therapeutic administration, the active compound or compounds can be incorporated with excipients and used in the form of tablets, capsules, lozenges, or troches. Pharmaceutically compatible binding agents and adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches, and the like can contain any of the following ingredients or compounds of a similar nature: a binder such as, but not limited to, gum tragacanth, acacia, corn starch, or gelatin; an excipient such as microcrystalline cellulose, starch, or lactose; a disintegrating agent such as, but not limited to, alginic acid and corn starch; a lubricant such as, but not limited to, magnesium stearate; a glidant, such as, but not limited to, colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; and a flavoring agent such as peppermint, or fruit flavoring.

When the dosage unit form is a capsule, it can contain, in addition to material of the above type, a liquid carrier such as a fatty oil. In addition, dosage unit forms can contain various other materials, which modify the physical form of the dosage unit, for example, coatings of sugar and other enteric agents. The compounds can also be administered as a component of an elixir, suspension, syrup, wafer, chewing gum or the like. A syrup may contain, in addition to the active compounds, sucrose as a sweetening agent and certain preservatives, dyes, colorings, and flavors. The active materials can also be mixed with other active materials that do not impair the desired action, or with materials that supplement the desired action.

Solutions or suspensions used for parenternal, intradermal, subcutaneous, or topical application can include any of the following components: a sterile diluent such as water for injection, saline solution, fixed oil, a naturally occurring vegetable oil such as sesame oil, coconut oil, peanut oil, cottonseed oil, and the like, or a synthetic fatty vehicle such as ethyl oleate, and the like, polyethylene glycol, glycerine, propylene glycol, or other synthetic solvent; antimicrobial agents such as benzyl alcohol and methyl parabens; antioxidants such as ascorbic acid and sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid (EDTA); buffers such as acetates, citrates, and phosphates; and agents for the adjustment of tonicity such as sodium chloride and dextrose. Parenternal preparations can be enclosed in ampoules, disposable syringes, or multiple dose vials made of glass, plastic, or other suitable material. Buffers, preservatives, antioxidants, and the like can be incorporated as required.

Where administered intravenously, suitable carriers include physiological saline, phosphate buffered saline (PBS), and solutions containing thickening and solubilizing agents such as glucose, polyethylene glycol, polypropyleneglycol, and mixtures thereof. Liposomal suspensions including tissue-targeted liposomes may also be suitable as pharmaceutically acceptable carriers. These may be prepared according to methods known, for example, as described in U.S. Pat. No. 4,522,811, which is incorporated by reference herein.

The active compounds may be prepared with carriers that protect the compound against rapid elimination from the body, such as time-release formulations or coatings such as enteric coatings to protect the compounds of the present invention from the acidic environment of the stomach. Enteric coated tablets are well known to those skilled in the art. In addition, capsules filled with small spheres, each coated to protect from the acidic stomach, are also well known to those skilled in the art. Other such carriers include controlled release formulations, such as, but not limited to, implants and microencapsulated delivery systems, and biodegradable, biocompatible polymers such as collagen, ethylene vinyl acetate, polyanhydrides, polyglycolic acid, polyorthoesters, polylactic acid, and the like. Methods for preparation of such formulations are known to those skilled in the art.

The compounds of the invention can be administered orally, parenterally (IV, IM, depo-IM, SQ, and depo-SQ), sublingually, intranasally (inhalation), intrathecally, topically, or rectally. Dosage forms known to those skilled in the art are suitable for delivery of the compounds of the invention.

When administered orally, compounds of the invention can be administered in usual dosage forms for oral administration as is well known to those skilled in the art and are described more fully herein. These dosage forms include the usual solid unit dosage forms of tablets and capsules as well as liquid dosage forms such as solutions, suspensions, and elixirs. When the solid dosage forms are used, it is preferred that they be of the sustained release type so that the compounds of the invention need to be administered only once or twice daily.

The compounds of the invention can be administered parenterally, for example, by IV, IM, depo-IM, SC, or depo-SC. When administered parenterally, a therapeutically effective amount for humans of about 0.5 to about 100 mg/day, preferably from about 5 to about 50 mg daily should be delivered. When a depot formulation is used for injection once a month or once every two weeks, the dose for humans should be about 0.5 mg/day to about 50 mg/day, or a monthly dose of from about 15 mg to about 1,500 mg. Dosing for other types of patients can be estimated from the appropriate human dose.

The compounds of the invention can be administered sublingually. When given sublingually, the compounds of the invention should be given one to four times daily in the amounts described above for IM administration.

The compounds of the invention can also be administered intranasally. When given by this route, the appropriate dosage forms are a nasal spray or dry powder, as is known to those skilled in the art. The dosage of the compounds of the invention for intranasal administration is the amount described above for IM administration.

The compounds of the invention can be administered intrathecally. When given by this route the appropriate dosage form can be a parenteral dosage form as is known to those skilled in the art. The dosage of the compounds of the invention for intrathecal administration is the amount described above for IM administration.

The compounds of the invention can be administered topically. When given by this route, the appropriate dosage form is a cream, ointment, or patch. When administered topically, the dosage is from about 0.5 mg/day to about 200 mg/day. The compounds of the invention can be administered rectally by suppository as is known to those skilled in the art. When administered by suppository, the therapeutically effective amount is from about 0.5 mg to about 500 mg for humans. The compounds of the invention can be administered by implants as is known to those skilled in the art. When administering a compound of the invention by implant, the therapeutically effective amount is the amount described above for depot administration.

The invention herein is the novel compounds of the invention and new methods of using the compounds of the invention. Given a particular compound of the invention and a desired dosage form, one skilled in the art would know how to prepare and administer the appropriate dosage form.

Where the compounds of the invention exhibit insufficient solubility, methods for solubilizing may be used. Such methods are known and include, but are not limited to, using cosolvents such as dimethylsulfoxide (DMSO), using surfactants such as polysorbates including Tween® and dissolution in aqueous sodium bicarbonate. Derivatives of the compounds, such as salts or prodrugs may also be used in formulating effective pharmaceutical compositions.

The concentration of the compound is effective for delivery of an amount upon administration that lessens or ameliorates at least one symptom of the disorder for which the compound is administered. Typically, the compositions are formulated for single dosage administration. A suitable single dose is a dose that is capable of reducing bacterial infection and/or bacterial burden with the infectious bacteria when administered one or more times over a suitable time period. For example, a preferred single dose of a compound of Formula (I) ranges from about 1 microgram to about 10 milligrams, but can range up to 100 milligrams of the composition per kilogram body weight of the patient.

The active compound is typically included in the pharmaceutically acceptable carrier in an amount sufficient to exert a therapeutically useful effect in the absence of undesirable side effects on the patient treated. The therapeutically effective concentration may be determined empirically by testing the compounds in known in vitro and in vivo model systems for the treated disorder.

The compounds and compositions of the invention can be enclosed in multiple or single dose containers. The enclosed compounds and compositions can be provided in kits, for example, including component parts that can be assembled for use. For example, a compound of the invention in lyophilized form, and a suitable diluent, may be provided as separated components for combination prior to use. A kit may include a compound of the invention and a second therapeutic agent for co-administration. The compound of the invention and second therapeutic agent may be provided as separate component parts.

A kit herein may include a plurality of containers, each container holding one or more unit dose of the compound of the invention. The containers are preferably adapted for the desired mode of administration, including, but not limited to tablets, gel capsules, sustained-release capsules, and the like for oral administration; depot products, pre-filled syringes, ampules, vials, and the like for parenternal administration; and patches, medipads, creams, ointments, and the like for topical administration.

The concentration of active compound in the drug composition will depend on absorption, inactivation, and excretion rates of the active compound, the dosage schedule, and amount administered as well as other factors known to those of skill in the art. The active ingredient may be administered at once, or may be divided into a number of smaller doses to be administered at intervals of time. It is understood that the precise dosage and duration of treatment is a function of the disease being treated and may be determined empirically using known testing protocols or by extrapolation from in vivo or in vitro test data.

It is to be noted that concentrations and dosage values may also vary with the severity of the condition to be alleviated. It is to be further understood that for any particular subject, specific dosage regimens should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the composition(s), and that the concentration ranges set forth herein are exemplary only and are not intended to limit the scope or practice of the claimed compositions.

Compounds of the invention can be prepared as described in the following Examples.

The invention disclosed herein is exemplified by the following preparations and examples which should not be construed to limit the scope of the disclosure. Alternative mechanistic pathways and analogous structures will be apparent to those skilled in the art.

EXAMPLES Examples 1-478

The following abbreviations are used throughout the Example section and are not meant to limit the scope of the disclosure.

TLC=thin layer chromatography

eq.=equivalents

equiv.=equivalents

THF=tetrahydrofuran

DIPEA=diisopropylethylamine

DIEA=diisopropylethylamine

DCM=dichloromethane

MeOH=methanol

EtOAc=ethyl acetate

BOC₂O=di-tert-butyl dicarbonate

mCPBA=3-chloroperbenzoic acid

DMAP=4-(Dimethylamino)pyridine

TFA=trifluoroacetic acid

DMA=N,N-dimethylacetamide

TBTU=O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

DMSO=dimethyl sulfoxide

Et₂O=diethyl ether

MeCN=acetonitrile

DMF=N,N-dimethylformamide

NMP=1-Methyl-2-pyrrolidinone

The compounds of Examples 1-475, shown below in Tables 1 (thiazoyl amides), 2 (thiadiazolyl amides) and 3 (thiazoyl sulfonamides) were prepared by the methods described in Example 477 as indicated in the Tables using intermediates described in Example 476.

TABLE 1 Preparation of Thiazolyl Amides EX # NAME MOL FORMULA MOL WEIGHT MASS METHOD Starting Material 1 (SM1) Starting Material 2 (SM2) 1 N-((2-(3-(3,4-dichlorobenzyl) C17H20Cl2N4O3S 431.3 431, 3 Int. 12 Acetyl chloride ureido)thiazol-4-yl)methyl)-N- 433 (2-methoxyethyl)acetamide 2 3-(N-((2-(3-(3,4-dichlorobenzyl)ureido) C17H21Cl2N4O5PS 495.3 495, 3 Int. 23 Acetyl chloride thiazol-4-yl)methyl) acetamido) propylphosphonic acid 497 3 N-((2-(3-(3,4-dichlorobenzyl) C18H22Cl2N4O4S 461.4 461, 3 Int. 3 2-(2-Methoxyethoxy)acetyl chloride ureido)thiazol-4-yl)methyl)-2- 463 (2-methoxyethoxy)-N-methylacetamide 4 N-((2-(3-(3,4-dichlorobenzyl) C16H18Cl2N4O3S 417.3 417, 3 Int. 3 2-Methoxyacetyl chloride ureido)thiazol-4-yl)methyl)-2- 419 methoxy-N-methylacetamide 5 N-((2-(3-(3,4-dichlorobenzyl) C18H17Cl2N5O3S 454.3 454, 3 Int. 3 4-Methyl-isoxazole-5- ureido)thiazol-4-yl)methyl)- 456 carboxylic acid chloride N,4-dimethylisoxazole-5-carboxamide 6 N-((2-(3-(3,4-dichlorobenzyl) C17H15Cl2N5O3S 440.3 440, 3 Int. 3 Isoxazole-5-carboxylic acid ureido)thiazol-4-yl)methyl)-N- 442 chloride methylisoxazole-5-carboxamide 7 N-((2-(3-(3,4-dichlorobenzyl) C22H22Cl2N4O2S 477.4 477, 3 Int. 3 3-Phenylpropionyl chloride ureido)thiazol-4-yl)methyl)-N- 479 methyl-3-phenylpropanamide 8 N-((2-(3-(3,4-dichlorobenzyl) C18H16Cl2N4O3S 439.3 439, 3 Int. 3 2-Furoyl chloride ureido)thiazol-4-yl)methyl)-N- 441 methylfuran-2-carboxamide 9 N-((2-(3-(3,4-dichlorobenzyl) C23H24Cl2N4O3S 507.4 507, 3 Int. 3 4-Phenoxy-butyryl chloride ureido)thiazol-4-yl)methyl)-N- 509 methyl-4-phenoxybutanamide 10 1-(3,4-Dichloro-benzyl)-3-{4- C19H23Cl2N5O4S2 520.5 520, 3 Int. 3 N-(1,1-Dioxo-tetrahydrothiophen-3-yl- [3-(1,1-dioxo-tetrahydro-1l6- 522 methyl)carbamoyl chloride thiophen-3-ylmethyl)-1- methyl-ureidomethyl]-thiazol-2-yl}-urea 11 N-((2-(3-(3,4-dichlorobenzyl) C19H19Cl2N5O3S 468.4 468, 3 Int. 3 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)- 470 carboxylic acid chloride N,3,5-trimethylisoxazole-4-carboxamide 12 N-((2-(3-(3,4-dichlorobenzyl) C18H18Cl2N6O2S 453.4 453, 3 Int. 3 1-Methyl-imidazole-5- ureido)thiazol-4-yl)methyl)- 455 carboxylic acid chloride N,1-dimethyl-1H-imidazole-5-carboxamide 13 N-((2-(3-(3,4-dichlorobenzyl) C18H16Cl2N4O3S 439.3 439, 3 Int. 3 3-Furoyl chloride ureido)thiazol-4-yl)methyl)-N- 441 methylfuran-3-carboxamide 14 N-((2-(3-(3,4-dichlorobenzyl) C19H18Cl2N4O3S 453.3 453, 3 Int. 3 3-Methyl-2-furoyl chloride ureido)thiazol-4-yl)methyl)- 455 N,3-dimethylfuran-2-carboxamide 15 N-((2-(3-(3,4-dichlorobenzyl) C24H21Cl2N5O3S 530.4 530, 3 Int. 3 5-Methyl-3-phenyl-isoxazole- ureido)thiazol-4-yl)methyl)- 532 4-carboxylic acid chloride N,5-dimethyl-3-phenylisoxazole-4-carboxamide 16 N-((2-(3-(3,4-dichlorobenzyl) C20H21Cl2N5O3S 482.4 482, 3 Int. 8 3,5-Dimethyl-isoxazole-4-carboxylic acid ureido)thiazol-4-yl)methyl)-N- 484 chloride ethyl-3,5-dimethylisoxazole-4-carboxamide 17 N-((2-(3-(3,4-dichlorobenzyl) C21H23Cl2N5O3S 496.4 496, 3 Int. 9 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)-N-isopropyl-3,5- 498 carboxylic acid chloride dimethylisoxazole-4-carboxamide 18 N-((2-(3-(3,4-dichlorobenzyl) C23H21Cl2N7O2S 530.4 530, 3 Int. 3 5-Methyl-2-phenyl-2H-1,2,3- ureido)thiazol-4-yl)methyl)- 532 triazole-4-carboxylic acid N,5-dimethyl-2-phenyl-2H- chloride 1,2,3-triazole-4-carboxamide 19 N-((2-(3-(3,4- C18H17Cl2N5O3S 454.3 454, 3 Int. 3 5-Methylisoxazole-3-carboxylic acid dichlorobenzyl)ureido)thiazol-4-yl)methyl)- 456 chloride N,5-dimethylisoxazole-3-carboxamide 20 N-((2-(3-(3,4-dichlorobenzyl) C24H21Cl2N5O3S 530.4 530, 3 Int. 3 3-Methyl-5-phenylisoxazole- ureido)thiazol-4-yl)methyl)- 532 4-carboxylic acid chloride N,3-dimethyl-5-phenylisoxazole-4-carboxamide 21 N-((2-(3-(3,4-dichlorobenzyl) C21H19Cl2N7O3S2 552.5 552, 3 Int. 3 3-Methyl-5-(4-methyl-1,2,3- ureido)thiazol-4-yl)methyl)- 554 thiadiazol-5-yl)isoxazole-4- N,3-dimethyl-5-(4-methyl- carboxylic acid chloride 1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide 22 N-((2-(3-(3,4-dichlorobenzyl) C16H16Cl2N8O2S 455.3 455/457 2 Int. 3 2-(2H-Tetrazol-5-yl)acetic ureido)thiazol-4-yl)methyl)-N- acid methyl-2-(2H-tetrazol-5-yl)acetamide 23 N-((2-(3-(3,4-dichlorobenzyl) C22H18Cl2N4O3S 489.4 489, 3 Int. 3 Benzofuran-2-carboxylic acid ureido)thiazol-4-yl)methyl)-N- 491 chloride methylbenzofuran-2-carboxamide 24 N-(1-(2-(3-(3,4- C20H21Cl2N5O3S 482.4 482/484 3 Int. 10a 3,5-Dimethyl-isoxazole-4- dichlorobenzyl) carboxylic acid chloride ureido)thiazol-4-yl)ethyl)- N,3,5-trimethylisoxazole-4-carboxamide 25 N-((2-(3-(3,4-dichlorobenzyl) C16H14Cl2N6O3S 441.3 441/443 2 Int. 3 1,2,5-Oxadiazole-3-carboxylic ureido)thiazol-4-yl)methyl)-N- acid chloride methyl-1,2,5-oxadiazole-3-carboxamide 26 N-((2-(3-(3,4-dichlorobenzyl) C20H21Cl2N5O3S 482.4 482, 2 Int. 3 2-(3,5-Dimethylisoxazol-4- ureido)thiazol-4-yl)methyl)-2- 484 yl)acetic acid (3,5-dimethylisoxazol-4-yl)-N-methylacetamide 27 N-((2-(3-(3,4-dichlorobenzyl) C20H21Cl2N5O3S 482.4 482, 2 Int. 3 3-Ethyl-5-methylisoxazole-4- ureido)thiazol-4-yl)methyl)-3- 484 carboxylic acid ethyl-N,5-dimethylisoxazole-4-carboxamide 28 N-((2-(3-(3,4-dichlorobenzyl) C18H17Cl2N5O3S 454.3 454, 2 Int. 3 3-Methylisoxazole-4- ureido)thiazol-4-yl)methyl)- 456 carboxylic acid N,3-dimethylisoxazole-4-carboxamide 29 N-((2-(3-(3,4-dichlorobenzyl) C18H17Cl2N5O3S 454.3 454, 2 Int. 3 5-Methylisoxazole-4- ureido)thiazol-4-yl)methyl)- 456 carboxylic acid chloride N,5-dimethylisoxazole-4-carboxamide 30 5-cyclopropyl-N-((2-(3-(3,4- C20H19Cl2N5O3S 480.4 480, 2 Int. 3 5-Cyclopropylisoxazole-4- dichlorobenzyl)ureido)thiazol- 482 carboxylic acid 4-yl)methyl)-N-methylisoxazole-4-carboxamide 31 N-((2-(3-(3,4-dichlorobenzyl) C22H22Cl2N4O2S 477.4 477, 3 Int. 3 2,6-Dimethylbenzoyl chloride ureido)thiazol-4-yl)methyl)- 479 N,2,6-trimethylbenzamide 32 N-((2-(3-(3,4-dichlorobenzyl) C21H17Cl2N5O4S 506.4 506, 3 Int. 3 5-(Furan-2-yl)isoxazole-3- ureido)thiazol-4-yl)methyl)-5- 508 carboxylic acid chloride (furan-2-yl)-N-methylisoxazole-3-carboxamide 33 N-((2-(3-(3,4-dichlorobenzyl) C19H19Cl2N5O3S 468.4 468, 3 Int. 3 2,5-Dimethyloxazole-4- ureido)thiazol-4-yl)methyl)- 470 carboxylic acid chloride N,2,5-trimethyloxazole-4-carboxamide 34 N-((2-(3-(3,4-dichlorobenzyl) C23H19Cl2N5O2S2 532.5 532, 3 Int. 3 2-Phenylthiazole-4-carboxylic ureido)thiazol-4-yl)methyl)-N- 534 acid chloride methyl-2-phenylthiazole-4- carboxamide 35 N-((2-(3-(3,4-dichlorobenzyl) C27H27Cl2N5O5S 604.5 604, 3 Int. 11 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)-N- 606 carboxylic acid chloride (2,4-dimethoxybenzyl)-3,5- dimethylisoxazole-4- carboxamide 36 N-((2-(3-(3,4-dichlorobenzyl) C21H23Cl2N5O4S 512.4 512, 3 Int. 12 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)-N- 514 carboxylic acid chloride (2-methoxyethyl)-3,5- dimethylisoxazole-4- carboxamide 37 N-((2-(3-(3,4-dichlorobenzyl) C21H17Cl2N5O2S3 538.5 538, 3 Int. 3 2-(Thiophen-2-yl)thiazole-4- ureido)thiazol-4-yl)methyl)-N- 540 carboxylic acid chloride methyl-2-(thiophen-2- yl)thiazole-4-carboxamide 38 N-((2-(3-(3,4-dichlorobenzyl) C17H15Cl2N5O4S 456.3 456/458 2 Int. 3 3-Hydroxyisoxazole-5- ureido)thiazol-4-yl)methyl)-3- carboxylic acid hydroxy-N-methylisoxazole- 5-carboxamide 39 N-((2-(3-(3,4-dichlorobenzyl) C22H18Cl2N6O3S 517.4 517, 3 Int. 3 5-Phenyl-1,3,4-oxadiazole-2- ureido)thiazol-4-yl)methyl)-N- 519 carboxylic acid chloride methyl-5-phenyl-1,3,4- oxadiazole-2-carboxamide 40 N-((2-(3-(3,4-dichlorobenzyl) C19H18Cl2N4O3S 453.3 453, 3 Int. 3 5-Methyl-2-furoyl chloride ureido)thiazol-4-yl)methyl)- 455 N,5-dimethylfuran-2- carboxamide 41 N-((2-(3-(3,4-dichlorobenzyl) C17H16Cl2N6O3S 455.3 455, 2 Int. 3 4-Methyl-1,2,5-oxadiazole-3- ureido)thiazol-4-yl)methyl)- 457 carboxylic acid N,4-dimethyl-1,2,5- oxadiazole-3-carboxamide 42 4-Methyl-2-pyrazin-2-yl- C22H19Cl2N7O2S2 548.5 548, 3 Int. 3 2-(Pyrazin-2-yl)4- thiazole-5-carboxylic acid {2- 550 methylthiazole-5-carboxylic [3-(3,4-dichlorobenzyl) acid chloride ureido]-thiazol-4-ylmethyl}- methyl-amide 43 N-((2-(3-(3,4-dichlorobenzyl) C22H22Cl2N4O4S 509.4 509, 3 Int. 3 2,4-Dimethoxybenzoyl ureido)thiazol-4-yl)methyl)- 511 chloride 2,4-dimethoxy-N- methylbenzamide 44 N-((2-(3-(3,4-dichlorobenzyl) C21H20Cl2N4O3S 497.4 479, 3 Int. 3 4-Methoxybenzoyl chloride ureido)thiazol-4-yl)methyl)-4- 481 methoxy-N-methylbenzamide 45 N-((2-(3-(3,4-dichlorobenzyl) C22H22Cl2N4O4S 509.4 509, 3 Int. 3 3,4-Dimethoxybenzoyl ureido)thiazol-4-yl)methyl)- 511 chloride 3,4-dimethoxy-N- methylbenzamide 46 N-((2-(3-(3,4-dichlorobenzyl) C21H18Cl2N4O4S 493.4 493, 3 Int. 3 3,4-Methylenedioxybenzoyl ureido)thiazol-4-yl)methyl)-N- 495 chloride methylbenzo[1,3]dioxole-5- carboxamide 47 N-((2-(3-(3,4-dichlorobenzyl) C23H24Cl2N4O5S 539.4 539, 3 Int. 3 3,4,5-Trimethoxybenzoyl ureido)thiazol-4-yl)methyl)- 541 chloride 3,4,5-trimethoxy-N- methylbenzamide 48 N-((2-(3-(3,4-dichlorobenzyl) C19H16Cl2F3N5O3S 522.3 522, 2 Int. 3 5-Methyl-3-trifluoromethyl- ureido)thiazol-4-yl)methyl)- 524 isoxazole-4-carboxylic acid N,5-dimethyl-3- (trifluoromethyl)isoxazole-4- carboxamide 49 N-((2-(3-(3,4-dichlorobenzyl) C20H19Cl2N5O2S 464.4 464, 2 Int. 3 2-(Pyridin-3-yl)acetic acid ureido)thiazol-4-yl)methyl)-N- 466 methyl-2-(pyridin-3-yl) acetamide 50 N-(1-(2-(3-(3,4- C21H22Cl2N6O4S 525.4 525, 3 Int. 13 3,5-Dimethyl-isoxazole-4- dichlorobenzyl)ureido)thiazol- 527 carboxylic acid chloride 4-yl)-2-(methylamino)-2- oxoethyl)-N,3,5- trimethylisoxazole-4- carboxamide 51 N-((2-(3-(3,4-dichlorobenzyl) C21H21Cl2N5O2S 478.4 478, 2 Int. 3 2,4-Dimethylnicotinic acid ureido)thiazol-4-yl)methyl)- 480 N,2,4-trimethylnicotinamide 52 N-((2-(3-(3,4-dichlorobenzyl) C23H24Cl2N4O2S 491.4 491, 3 Int. 3 2,4,6-Trimethylbenzoyl ureido)thiazol-4-yl)methyl)- 493 chloride N,2,4,6-tetramethylbenzamide 53 N-((2-(3-(3,4-dichlorobenzyl) C20H21Cl2N5O4S 498.4 498, 3 Int. 14 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)-N- 500 carboxylic acid chloride (2-hydroxyethyl)-3,5- dimethylisoxazole-4- carboxamide 54 N-((2-(3-(3-fluorobenzyl) C19H20FN5O3S 417.5 418 3 Int. 5 3,5-Dimethyl-isoxazole-4- ureido)thiazol-4-yl)methyl)- carboxylic acid chloride N,3,5-trimethylisoxazole-4- carboxamide 55 N-((2-(3-(3-fluorobenzyl) C20H22FN5O4S 447.5 448 2 Int. 5 Int. 31 ureido)thiazol-4-yl)methyl)-5- (methoxymethyl)-N,3- dimethylisoxazole-4- carboxamide 56 N-((2-(3-(3,4-dichlorobenzyl) C20H21Cl2N5O4S 498.4 498, 2 Int. 3 Int. 31 ureido)thiazol-4-yl)methyl)-5- 500 (methoxymethyl)-N,3- dimethylisoxazole-4- carboxamide 57 N-((2-(3-(3-fluorobenzyl) C16H19FN4O3S 366.4 367 3 Int. 5 2-Methoxyacetyl chloride ureido)thiazol-4-yl)methyl)-2- methoxy-N-methylacetamide 58 methyl 2-(((2-(3-(3- C16H17FN4O4S 380.4 381 3 Int. 5 Methyl chlorooxoacetate fluorobenzyl)ureido)thiazol-4- yl)methyl)(methyl)amino)-2- oxoacetate 59 N-((2-(3-(3-fluorobenzyl) C18H18FN5O3S 403.4 404 2 Int. 5 3-Methylisoxazole-4- ureido)thiazol-4-yl)methyl)- carboxylic acid N,3-dimethylisoxazole-4- carboxamide 60 3-ethyl-N-((2-(3-(3- C20H22FN5O3S 431.5 432 2 Int. 5 3-Ethyl-5-methylisoxazole-4- fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N,5- dimethylisoxazole-4- carboxamide 61 N-((2-(3-(3-fluorobenzyl) C21H22FN5O2S 427.5 428 2 Int. 5 2,4-Dimethylnicotinic acid ureido)thiazol-4-yl)methyl)- N,2,4-trimethylnicotinamide 62 N-((2-(3-(3-fluorobenzyl) C18H17FN6O2S 400.4 401 2 Int. 5 Pyrazine-2-carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylpyrazine-2- carboxamide 63 N-((2-(3-(3,4-dichlorobenzyl) C18H16Cl2N6O2S 451.3 451, 2 Int. 3 Pyrimidine-5-carboxylic acid ureido)thiazol-4-yl)methyl)-N- 453 methylpyrimidine-5- carboxamide 64 N-((2-(3-(3-fluorobenzyl) C18H17FN6O2S 400.4 401 2 Int. 5 Pyrimidine-5-carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylpyrimidine-5- carboxamide 65 N-((2-(3-(3,4-dichlorobenzyl) C18H16Cl2N6O2S 451.3 451, 2 Int. 3 Pyrazine-2-carboxylic acid ureido)thiazol-4-yl)methyl)-N- 453 methylpyrazine-2- carboxamide 66 N-((2-(3-(3-fluorobenzyl) C15H17FN4O2S 336.4 337 3 Int. 5 Acetyl chloride ureido)thiazol-4-yl)methyl)-N- methylacetamide 67 N-((2-(3-(3-fluorobenzyl) C19H19FN6O2S 414.5 415 2 Int. 5 5-Methylpyrazine-2- ureido)thiazol-4-yl)methyl)- carboxylic acid N,5-dimethylpyrazine-2- carboxamide 68 N-((2-(3-(3-fluorobenzyl) C18H17FN4O3S 388.4 389 3 Int. 5 3-Furoyl chloride ureido)thiazol-4-yl)methyl)-N- methylfuran-3-carboxamide 69 N-((2-(3-(3-fluorobenzyl) C18H18FN5O3S 403.4 404 3 Int. 5 4-Methyloxazole-5-carboxylic ureido)thiazol-4-yl)methyl)- acid chloride N,4-dimethyloxazole-5- carboxamide 70 N-((2-(3-(3-fluorobenzyl) C18H18FN5O3S 403.4 404 3 Int. 5 5-Methylisoxazole-3- ureido)thiazol-4-yl)methyl)- carboxylic acid chloride N,5-dimethylisoxazole-3- carboxamide 71 N-((2-(3-(3-fluorobenzyl) C22H23FN4O4S2 490.6 491 2 Int. 5 2-(4- ureido)thiazol-4-yl)methyl)-N- Methylphenylsulfonyl)acetic methyl-2-tosylacetamide acid 72 Ethyl 4-(((2-(3-(3- C21H22FN5O5S 475.5 476 2 Int. 5 Int. 35 fluorobenzyl)ureido)thiazol-4- yl)methyl)(methyl)carbamoyl)- 5-methylisoxazole-3- carboxylate 73 4-(((2-(3-(3-fluorobenzyl) C19H18FN5O5S 447.4 448 9 Ethyl 4-(((2-(3-(3- None ureido)thiazol-4-yl)methyl) fluorobenzyl)ureido)thiazol- (methyl)carbamoyl)-5- 4-yl)methyl)(methyl) methylisoxazole-3-carboxylic carbamoyl)-5- acid methylisoxazole-3- carboxylate (EX# 72) 74 N-((2-(3-(3-fluorobenzyl) C20H20FN5O2S 413.5 414 2 Int. 5 2-Methylnicotinic acid ureido)thiazol-4-yl)methyl)- N,2-dimethylnicotinamide 75 N-((2-(3-(3-fluorobenzyl) C18H18FN5O3S 403.4 404 2 Int. 5 5-Methylisoxazole-4- ureido)thiazol-4-yl)methyl)- carboxylic acid N,5-dimethylisoxazole-4- carboxamide 76 N-((2-(3-(3-fluorobenzyl) C20H20FN5O2S 413.5 414 2 Int. 5 4-Methylnicotinic acid ureido)thiazol-4-yl)methyl)- N,4-dimethylnicotinamide 77 3-chloro-N-((2-(3-(3- C19H18ClFN4O4S3 517.0 517, 3 Int. 5 3-Methyl-4-(methylsulfonyl)- fluorobenzyl)ureido)thiazol-4- 519 thiophene-2-carboxylic acid yl)methyl)-N-methyl-4- chloride (methylsulfonyl)thiophene-2- carboxamide 78 N-((2-(3-(3-fluorobenzyl) C18H18FN5O2S2 419.5 421 3 Int. 5 4-Methylthiazole-5-carboxylic ureido)thiazol-4-yl)methyl)- acid chloride N,4-dimethylthiazole-5- carboxamide 79 N-((2-(3-(3-fluorobenzyl) C20H19FN6O3S2 474.5 475 2 Int. 5 5-Oxo-3,5-dihydro-5H- ureido)thiazol-4-yl)methyl)-N- thiazolo[3,2-a]pyrimidine-6- methyl-5-oxo-3,5-dihydro-2H- carboxylic acid thiazolo[3,2-a]pyrimidine-6- carboxamide 80 N-((2-(3-(3-fluorobenzyl) C20H21FN6O2S2 460.6 461 2 Int. 5 4-methyl-2-methylthio- ureido)thiazol-4-yl)methyl)- pyrimidine-5-carboxylic acid N,4-dimethyl-2- (methylthio)pyrimidine-5- carboxamide 81 N-((2-(3-(3-fluorobenzyl) C18H21FN4O2S 376.5 377 3 Int. 5 3-Methyl-but-2-enoyl chloride ureido)thiazol-4-yl)methyl)- N,3-dimethylbut-2-enamide 82 N-((2-(3-(3-fluorobenzyl) C21H21FN4O2S 412.5 413 3 Int. 5 2-Methylbenzoyl chloride ureido)thiazol-4-yl)methyl)- N,2-dimethylbenzamide 83 N-((2-(3-(3-fluorobenzyl) C22H19FN6O2S 450.5 451 2 Int. 5 Quinoxaline-2-carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylquinoxaline-2- carboxamide 84 N-((2-(3-(3-fluorobenzyl) C20H20FN5O2S 413.5 414 2 Int. 5 3-Methylpicolinic acid ureido)thiazol-4-yl)methyl)- N,3-dimethylpicolinamide 85 N-((2-(3-(3-fluorobenzyl) C27H28FN5O5S 553.6 554 2 Int. 5 5-((4-methoxybenzyloxy) ureido)thiazol-4-yl)methyl)-5- methyl)-3-methylisoxazole-4- ((4-methoxybenzyloxy) carboxylic acid methyl)-N,3- dimethylisoxazole-4- carboxamide 86 N-(2-Aminoethyl)-N-((2-(3- C20H23FN6O3S 446.5 447 3; 1  Int. 15 3,5-Dimethyl-isoxazole-4- (3-fluorobenzyl) carboxylic acid chloride ureido)thiazol-4-yl)methyl)- 3,5-dimethylisoxazole-4- carboxamide 87 4-amino-N-((2-(3-(3- C18H18FN7O2S 415.5 416 2 Int. 5 4-Aminopyrimidine-5- fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N- methylpyrimidine-5- carboxamide 88 2-amino-N-((2-(3-(3- C19H20FN7O2S 429.5 430 2 Int. 5 2-Amino-4-methyl- fluorobenzyl)ureido)thiazol-4- pyrimidine-5-carboxylic acid yl)methyl)-N,4- dimethylpyrimidine-5- carboxamide 89 N-((2-(3-(3-fluorobenzyl) C21H25FN6O5S2 524.6 526 5 N-(2-Aminoethyl)-N-((2-(3- Methanesulfonyl chloride ureido)thiazol-4-yl)methyl)- (3-fluorobenzyl)ureido) 3,5-dimethyl-N-(2- thiazol-4-yl)methyl)3,5- (methylsulfonamido)ethyl)isoxazole- dimethylisoxazole-4- 4-carboxamide carboxamide (EX# 86) 90 N-((2-(3-(3-fluorobenzyl) C21H22FN5O3S 443.5 444 2 Int. 5 4,6-Dimethyl-2-oxo-1,2- ureido)thiazol-4-yl)methyl)- dihydropyridine-3-carboxylic N,4,6-trimethyl-2-oxo-1,2- acid dihydropyridine-3- carboxamide 91 N-((2-(3-(3-fluorobenzyl) C21H23FN6O2S 442.5 443 2 Int. 5 2,4,6-Trimethylpyrimidine-5- ureido)thiazol-4-yl)methyl)- carboxylic acid N,2,4,6-tetramethylpyrimidine- 5-carboxamide 92 N-((2-(3-(3-fluorobenzyl) C19H19FN6O2S 414.5 415 2 Int. 5 3-Methylpyrazine-2- ureido)thiazol-4-yl)methyl)- carboxylic acid (Int. 34) N,3-dimethylpyrazine-2- carboxamide 93 tert-butyl 2-(((2-(3-(3- C23H28FN7O4S 517.6 Andras 2 Int. 5 4-tert-Butoxycrarbonylamino- fluorobenzyl)ureido)thiazol-4- 1-methyl-1H-imidazole-2- yl)methyl)(methyl)carbamoyl)- carboxylic acid 1-methyl-1H-imidazol-4- ylcarbamate 94 4-amino-N-((2-(3-(3- C18H20FN7O2S 417.5 418 1 tert-butyl 2-(((2-(3-(3- None fluorobenzyl)ureido)thiazol-4- fluorobenzyl)ureido)thiazol- yl)methyl)-N,1-dimethyl-1H- 4-yl)methyl)(methyl) imidazole-2-carboxamide carbamoyl)-1-methyl-1H- imidazol-4-ylcarbamate (EX# 93) 95 4-acetamido-N-((2-(3-(3- C20H22FN7O3S 459.5 460 3 4-amino-N-((2-(3-(3- Acetyl chloride fluorobenzyl)ureido)thiazol-4- fluorobenzyl)ureido)thiazol- yl)methyl)-N,1-dimethyl-1H- 4-yl)methyl)-N,1-dimethyl- imidazole-2-carboxamide 1H-imidazole-2- carboxamide (EX# 94) 96 N-((2-(3-(3-fluorobenzyl) C20H21FN6O2S 428.5 429 2 Int. 5 4,6-Dimethylpyrimidine-5- ureido)thiazol-4-yl)methyl)- carboxylic acid N,4,6-trimethylpyrimidine-5- carboxamide 97 N-((2-(3-(3-fluorobenzyl) C19H20FN5O4S 433.5 434 12 Ethyl 4-(((2-(3-(3- Lithium borohydride ureido)thiazol-4-yl)methyl)-3- fluorobenzyl)ureido)thiazol- (hydroxymethyl)-N,5- 4-yl)methyl)(methyl) dimethylisoxazole-4- carbamoyl)-5- carboxamide methylisoxazole-3- carboxylate (EX# 72) 98 N-((2-(3-(4-fluorobenzyl) C19H20FN5O3S 417.5 418 8 Int. 18 3-Fluorobenzylamine ureido)thiazol-4-yl)methyl)- N,3,5-trimethylisoxazole-4- carboxamide 99 N-((2-(3-(3,5-difluorobenzyl) C19H19F2N5O3S 435.5 436 8 Int. 18 3,5-Difluorobenzylamine ureido)thiazol-4-yl)methyl)- N,3,5-trimethylisoxazole-4- carboxamide 100 N-((2-(3-(3-fluorobenzyl) C20H20FN5O2S 413.5 414 2 Int. 5 3-Methyl-isonicotinic acid ureido)thiazol-4-yl)methyl)- N,3-dimethylisonicotinamide 101 N-((2-(3-(3-chlorobenzyl) C19H20ClN5O3S 433.9 434 8 Int. 18 3-Chlorobenzylamine ureido)thiazol-4-yl)methyl)- N,3,5-trimethylisoxazole-4- carboxamide 102 N-((2-(3-(benzo[1,3] dioxol-5- C20H21N5O5S 443.5 444 8 Int. 18 Piperonylamine ylmethyl)ureido) thiazol-4- yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamie 103 2-amino-N-((2-(3-(3- C20H22FN7O2S 443.5 444 2 Int. 5 2-Amino-4,6- fluorobenzyl)ureido)thiazol-4- dimethylpyrimidine-5- yl)methyl)-N,4,6- carboxylic acid trimethylpyrimidine-5- carboxamide 104 N-((2-(3-((2,2-difluorobenzo C20H19F2N5O5S 479.5 480 8; 10 Int. 18 2,4-Dimethoxybenzyl(C-2,2- [1,3]dioxol-5-yl)methyl) difluoro-benzo[1,3]dioxol-5- ureido)thiazol-4-yl)methyl)- yl)methyl)amine (per Method N,3,5-trimethylisoxazole-4- 13) carboxamide 105 N-((2-(3-(3-fluorobenzyl) C22H21FN6O2S 452.5 453 2 Int. 5 2-Methylimidazo[1,2- ureido)thiazol-4-yl)methyl)- a]pyridine-3-carboxylic acid N,2-dimethylimidazo[1,2- a]pyridine-3-carboxamide 106 N,3,5-trimethyl-N-((2-(3-(3- C22H26N6O4S 470.6 471 8 Int. 18 3-(N-Acety-methylamino) (N-methylacetamido) benzylamine benzyl)ureido)thiazol-4- yl)methyl)isoxazole-4- carboxamide 107 N-((2-(3-((5-chlorothiophen- C17H18ClN5O3S2 439.9 440, 8; 10 Int. 18 (5-Chlorothiophen-2-yl- 2-yl)methyl)ureido)thiazol-4- 442 methyl)(2,4-dimethoxybenzyl) yl)methyl)-N,3,5- amine (per Method 13) trimethylisoxazole-4- carboxamide 108 N-((2-(3-(3-fluorobenzyl) C18H21FN4O3S 392.5 393 2 Int. 5 Tetrahydro-2-furoic acid ureido)thiazol-4-yl)methyl)-N- methyltetrahydrofuran-2- carboxamide 109 1-(4-((2,4-dioxothiazolidin-3- C15H13FN4O3S2 380.4 381 14 Int. 7 Thiazolidine-2,4-dione yl)methyl)thiazol-2-yl)-3-(3- fluorobenzyl)urea 110 N-((2-(3-(3-fluorobenzyl) C20H20FN5O3S 429.5 430 2 Int. 5 2-Methoxynicotinic acid ureido)thiazol-4-yl)methyl)-2- methoxy-N- methylnicotinamide 111 N-((2-(3-(3-fluorobenzyl) C18H21FN4O3S 392.5 393 2 Int. 5 Tetrahydro-3-furoic acid ureido)thiazol-4-yl)methyl)-N- methyltetrahydrofuran-3- carboxamide 112 N,3,5-trimethyl-N-((2-(3- C17H19N5O3S2 405.5 406 8 Int. 18 Thiophen-3-yl-methylamine (thiophen-3-ylmethyl)ureido) thiazol-4-yl)methyl)isoxazole- 4-carboxamide 113 methyl (2-(3-(3-fluorobenzyl) C16H19FN4O4S 382.4 383 3 Int. 19 Methyl chloroformate ureido)thiazol-4-yl)methyl(2- hydroxyethyl)carbamate 114 N-((2-(3-(3-fluorobenzyl) C21H22FN5O3S 443.5 444 2 Int. 19 3-Methyl-isonicotinic acid ureido)thiazol-4-yl)methyl)-N- (2-hydroxyethyl)-3- methylisonicotinamide 115 1-(3-fluorobenzyl)-3-(4-((2- C15H15FN4O3S 350.4 351 15 Int. 21 Oxazolidin-2-one oxooxazolidin-3- yl)methyl)thiazol-2-yl)urea 116 2-chloro-N-((2-(3-(3- C19H17ClFN5O2S 433.9 434 2 Int. 5 2-Chloronicotinic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N- methylnicotinamide 117 N-((2-(3-(3-fluorobenzyl) C20H23FN6O2S 430.5 431 2 Int. 5 1,3,5-Trimethyl-1H-pyrazole- ureido)thiazol-4-yl)methyl)- 4-carboxylic acid N,1,3,5-tetramethyl-1H- pyrazole-4-carboxamide 118 (S)-N-((2-(3-(3-fluorobenzyl) C18H21FN4O3S 392.5 393 2 Int. 5 (S)-Tetrahydro-2-furoic acid ureido)thiazol-4-yl)methyl)-N- methyltetrahydrofuran-2- carboxamide 119 (R)-N-((2-(3-(3-fluorobenzyl) C18H21FN4O3S 392.5 393 2 Int. 5 (R)-Tetrahydro-2-furoic acid ureido)thiazol-4-yl)methyl)-N- methyltetrahydrofuran-2- carboxamide 120 N-((2-(3-(3-fluorobenzyl) C22H24FN5O3S 457.5 458 2 Int. 5 3-n-Propoxylpicolinic acid ureido)thiazol-4-yl)methyl)-N- methyl-3- propoxypicolinamide 121 tert-butyl 2-(((2-(3-(3- C23H30FN5O5S 507.6 508 2 Int. 5 N-(tert-Butoxycarbonyl) fluorobenzyl)ureido)thiazol-4- morpholine-2-carboxylic acid yl)methyl)(methyl)carbamoyl) morpholine-4-carboxylate 122 N-((2-(3-(3-fluorobenzyl) C18H22FN5O3S 407.5 408 1 tert-butyl 2-(((2-(3-(3- none ureido)thiazol-4-yl)methyl)-N- fluorobenzyl)ureido)thiazol- methylmorpholine-2- 4-yl)methyl)(methyl) carboxamide carbamoyl)morpholine-4- carboxylate (EX# 121) 123 N-((2-(3-(3,5-difluorobenzyl) C19H18F2N6O2S 432.5 433 2 Int. 20 3-Methyl-pyrazine-2- ureido)thiazol-4-yl)methyl)- carboxylic acid (Int. 34) N,3-dimethylpyrazine-2- carboxamide 124 N-((2-(3-(3,5-difluorobenzyl) C20H19F2N5O2S 431.5 432 2 Int. 20 3-Methyl-isonicotinic acid ureido)thiazol-4-yl)methyl)- N,3-dimethylisonicotinamide 125 N-((2-(3-(3- C18H17FN6O2S 400.4 401 2 Int. 5 Pyridazine-4-carboxylic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N- methylpyridazine-4- carboxamide 126 N-((2-(3-(3-fluorobenzyl) C19H21FN6O2S 416.5 417 2 Int. 5 3,5-Dimethyl-1H-pyrazole-4- ureido)thiazol-4-yl)methyl)- carboxylic acid N,3,5-trimethyl-1H-pyrazole- 4-carboxamide 127 N-((2-(3-(3-fluorobenzyl) C18H17FN6O2S 400.4 401 2 Int. 5 Pyridazine-3-carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylpyridazine-3- carboxamide 128 N-((2-(3-(3-fluorobenzyl) C19H23FN4O3S 406.5 407 2 Int. 5 Tetrahydro-2H-pyran-4- ureido)thiazol-4-yl)methyl)-N- carboxylic acid methyltetrahydro-2H-pyran-4- carboxamide 129 N-((2-(3-(3-fluorobenzyl) C19H21FN6O2S 416.5 417 2 Int. 5 1,5-Dimethylpyrazole-4- ureido)thiazol-4-yl)methyl)- carboxylic acid N,1,5-trimethyl-1H-pyrazole- 4-carboxamide 130 N-((2-(3-((5-chlorofuran-2- C17H18ClN5O4S 423.9 425 8; 10 Int. 18 (5-Chlorothiophen-2-yl- yl)methyl)ureido)thiazol-4- methyl)(2,4-dimethoxybenzyl) yl)methyl)-N,3,5- amine (per Method 13) trimethylisoxazole-4- carboxamide 131 N-((2-(3-(3-fluorobenzyl) C18H22FN5O3S 407.5 408 4 Int. 5 N-(tert-Butoxycarbonyl) ureido)thiazol-4-yl)methyl)-N- morpholine-3-carboxylic acid methylmorpholine-3- carboxamide 132 N-((2-(3-(3-fluorobenzyl) C19H24FN5O2S 405.5 406 4 Int. 5 N-(tert-Butoxycarbonyl)-4- ureido)thiazol-4-yl)methyl)- methylpyrrolidine-3- N,4-dimethylpyrrolidine-3- carboxylic acid carboxamide 133 (S)-N-((2-(3-(3-fluorobenzyl) C18H22FN5O2S 391.5 392 4 Int. 5 (S)-N-(tert-Butoxycarbonyl) ureido)thiazol-4-yl)methyl)-N- pyrrolidine-2-carboxylic acid methylpyrrolidine-2- carboxamide 134 2-Methyl-5,6-dihydro-4H- C₂₀H₂₃FN₄O₃S 418.5 419 2 Int.5 2-Methyl-5,6-dihydro-4H- pyran-3-carboxylic acid {2-[3- pyran-3-carboxylic acid (3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 135 2-Methyl-5-morpholin-4- C₂₄H₂₈FN₅O₄S 501.6 502 2 Int.5 2-Methyl-5-(morpholin-4- ylmethyl-furan-3-carboxylic ylmethyl)furan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)- acid ureido]-thiazol-4-ylmethyl}- methyl-amide 136 2-Methyl-but-2-enoic acid {2- C₁₈H₂₁FN₄O₂S 376.4 377 2 Int.5 2-Methyl-but-2-enoic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 137 1,2,3-Thiadiazole-4- C₁₆H₁₅FN₆O₂S₂ 406.5 407 2 Int.5 1,2,3-Thiadiazole-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 138 3,5-Dimethyl-isoxazole-4- C₁₇H₁₈FN₅O₃S₂ 423.5 424 8 Int. 18 C-(5-Fluoro-thiophen-2- carboxylic acid {2-[3-(5- yl)methylamine (Int. 36) fluoro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 139 2-Pyridin-3-yl-thiazole-4- C₂₂H₁₉FN₆O₂S₂ 482.6 483 2 Int.5 2-Pyridin-3-yl-thiazole-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 140 2,5-Dimethyl-2H-pyrazole-3- C₁₉H₂₁FN₆O₂S 416.5 417 2 Int.5 2,5-Dimethyl-2H-pyrazole-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 141 4-Methyl-furazan-3- C₁₇H₁₇FN₆O₃S 404.4 405 2 Int.5 4-Methyl-furazan-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 142 2-Morpholin-4-ylmethyl- C₂₃H₂₆FN₅O₄S 487.5 488 2 Int.5 2-Morpholin-4-ylmethyl-3- furan-3-carboxylic acid {2-[3- furoic acid (3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 143 1-Methyl-pyrrolidine-2- C₁₉H₂₄FN₅O₂S 405.5 406 2 Int.5 1-Methyl-pyrrolidine-2- carboxylic acid {2-[3-(3- carboxylc acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 144 1-Methyl-1H-pyrrole-2- C₁₉H₂₀FN₅O₂S 401.5 402 2 Int.5 1-Methyl-1H-pyrrole-2- carboxylic acid {2-[3-(3- carboxylc acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 145 1,5-Dimethyl-1H- C₁₈H₂₀FN₇O₂S 417.5 418 2 Int.5 1,5-Dimethyl-1H- [1,2,3]triazole-4-carboxylic [1,2,3]triazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)- acid ureido]-thiazol-4-ylmethyl}- methyl-amide 146 5-Fluoro-thiophene-2- C₁₈H₁₆F₂N₄O₂S₂ 422.5 423 2 Int.5 5-Fluoro-thiophene-2- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 147 4-Methyl-pyrimidine-5- C₁₉H₁₉FN₆O₂S 414.5. 415 2 Int.5 4-Methyl-pyrimidine-5- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 148 4-Methyl-2-phenyl- C₂₅H₂₃FN₆O₂S 490.6 491 2 Int.5 4-Methyl-2-phenyl- pyrimidine-5-carboxylic acid pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 149 N-{2-[3-(3-Fluoro-benzyl)- C₂₀H₂₀FN₅O₂S₂ 445.5 446 3 Int.5 2-Methylthio-nicotinic acid ureido]-thiazol-4-ylmethyl}- N-methyl-2-methylsulfanyl- nicotinamide 150 2-Cyano-N-{2-[3-(3-fluoro- C₁₆H₁₆FN₅O₂S 361.4 362 2 Int.5 2-Cyanoacetic acid benzyl)-ureido]-thiazol-4- ylmethyl}-N-methyl- acetamide 151 3,5-Dimethyl-isoxazole-4- C₁₉H₁₉BrFN₅O₃S 496.4 498 17 N-((2-(3-(3-Fluorobenzyl) Bromine carboxylic acid {5-bromo-2- ureido)thiazol-4-yl)methyl)- [3-(3-fluoro-benzyl)-ureido]- N,3,5-trimethylisoxazole-4- thiazol-4-ylmethyl}-methyl- carboxamide (EX# 54) amide 152 N-{2-[3-(3-Fluoro-benzyl)- C₂₃H₂₅FN₆O₃S 484.5 485 3 Int.5 6-Morpholin-4-yl-nicotinic ureido]-thiazol-4-ylmethyl}- acid chloride N-methyl-6-morpholin-4-yl- nicotinamide 153 4-Methyl-thiazole-5- C₁₈H₁₈FN₅O₂S₂ 419.5 420 2 Int.5 4-Methylthiazole-5-carboxylic carboxylic acid {2-[3-(3- acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 154 3-Methyl-1H-pyrazole-4- C₁₈H₁₉FN₆O₂S 402.4 403 2 Int.5 3-Methyl-1H-pyrazole-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 155 2,4-Dimethyl-pyrimidine-5- C₂₀H₂₁FN₆O₂S 428.5 429 2 Int.5 2,4-Dimethyl-pyrimidine-5- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 156 2-Methyl-[1,6]naphthyridine- C₂₃H₂₁FN₆O₂S 464.5 465 2 Int.5 2-Methyl[1,6]napthyridine-3- 3-carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 157 6-(4-Methoxy-phenyl)- C₂₅H₂₃FN₆O₃S 506.6 507 2 Int.5 6-(4-Methoxyphenyl) pyridazine-3-carboxylic acid pyridazine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 158 3-Methyl-pyrazine-2- C₁₉H₁₈BrFN₆O₂S 493.4 495 17 N-((2-(3-(3-fluorobenzyl) Bromine carboxylic acid {5-bromo-2- ureido)thiazol-4-yl)methyl)- [3-(3-fluoro-benzyl)-ureido]- N,3-dimethylpyrazine-2- thiazol-4-ylmethyl}-methyl- carboxamide (EX# 92) amide 159 3-Methyl-pyrazine-2- C₁₉H₁₈ClFN₆O₂S 448.9 449 18 N-((2-(3-(3-fluorobenzyl) N-Chlorosuccinimide carboxylic acid {5-chloro-2- ureido)thiazol-4-yl)methyl)- [3-(3-fluoro-benzyl)-ureido]- N,3-dimethylpyrazine-2- thiazol-4-ylmethyl}-methyl- carboxamide (EX# 92) amide 160 2,6-Bis-dimethylamino- C₂₂H₂₇FN₈O₂S 486.6 487 2 Int. 5 2,6-Bis-dimethylamino- pyrimidine-4-carboxylic acid pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl) ureido]-thiazol-4-ylmethyl}- methyl-amide 161 2,6-Di-morpholin-4-yl- C₂₆H₃₁FN₈O₄S 570.6 571 2 Int. 5 2,6-Di-morpholin-4-yl- pyrimidine-4-carboxylic acid pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 162 2-Cyano-N-{2-[3-(3-fluoro- C₂₂H₁₉FN₆O₂S 450.5 451 2 Int. 5 2-Cyano-3-pyridin-3-yl- benzyl)-ureido]-thiazol-4- acrylic acid ylmethyl}-N-methyl-3- pyridin-3-yl-acrylamide 163 2-Methyl-[1,8]naphthyridine- C₂₃H₂₁FN₆O₂S 464.5 465 2 Int. 5 2-Methyl-[1,8]naphthyridine- 3-carboxylic acid {2-[3-(3- 3-carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 164 2-Dimethylamino-6-methyl- C₂₁H₂₄FN₇O₂S 457.5 458 2 Int. 5 2-Dimethylamino-6-methyl- pyrimidine-4-carboxylic acid pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 165 N-{2-[3-(3-Fluoro-benzyl)- C₂₂H₂₃FN₄O₃S 442.5 443 2 Int. 5 2-Methoxy-2-phenylacetic ureido]-thiazol-4-ylmethyl}-2- acid methoxy-N-methyl-2-phenyl- acetamide 166 3-Methyl-pyrazine-2- C₁₇H₁₇FN₆O₂S₂ 420.5 421 8 Int. 22 C-(5-Fluoro-thiophen-2- carboxylic acid {2-[3-(5- yl)methylamine (Int. 36) fluoro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 167 3-Methyl-pyrazine-2- C₁₇H₁₈N₆O₂S₂ 402.5 403 8 Int. 22 C-(thiophen-3-yl)methylamine carboxylic acid methyl-[2-(3- thiophen-3-ylmethyl-ureido)- thiazol-4-ylmethyl]-amide 168 3,5-Dimethyl-isoxazole-4- C₂₀H₁₉FN₆O₃S 442.5 443 19 3,5-Dimethyl-isoxazole-4- CuCN carboxylic acid {5-cyano-2- carboxylic acid {5-bromo-2- [3-(3-fluoro-benzyl)-ureido]- [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- thiazol-4-ylmethyl}-methyl- amide amide (EX# 151) 169 Acetic acid 1-({2-[3-(3-fluoro- C₁₈H₂₁FN₄O₄S 408.4 409 2 Int. 5 2-Acetoxypropionic acid benzyl)-ureido]-thiazol-4- ylmethyl}-methyl-carbamoyl)- ethyl ester 170 1-Ethyl-3-methyl-1H- C₂₀H₂₃FN₆O₂S 430.5 431 2 Int. 5 1-Ethyl-3-methyl-1H- pyrazole-4-carboxylic acid {2- pyrazole-4-carboxylid acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 171 2-Methyl-pyrazolo[1,5- C₂₁H₂₀FN₇O₂S 453.5 454 2 Int. 5 2-Methyl-pyrazolo[1,5- a]pyrimidine-3-carboxylic a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)- acid ureido]-thiazol-4-ylmethyl}- methyl-amide 172 N-{2-[3-(3-Fluoro-benzyl)- C₁₆H₁₉FN₄O₃S 366.4 367 20 Acetic acid 1-({2-[3-(3- none ureido]-thiazol-4-ylmethyl}-2- fluoro-benzyl)-ureido]- hydroxy-N-methyl- thiazol-4-ylmethyl}-methyl- propionamide carbamoyl)-ethyl ester (EX# 169) 173 3,5-Dimethyl-isoxazole-4- C₁₉H₂₀FN₅O₃S 417.5 418 3 Int. 10b 3,5-Dimethyl-isoxazole-4- carboxylic acid (1-{2-[3-(3- carboxylic acid chloride fluoro-benzyl)-ureido]-thiazol- 4-yl}-ethyl)-amide 174 1-Ethyl-5-methyl-1H- C₂₀H₂₃FN₆O₂S 430.5 431 2 Int. 5 1-Ethyl-5-methyl-1H- pyrazole-4-carboxylic acid {2- pyrazole-4-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 175 5,7-Dimethyl-pyrazolo[1,5- C₂₂H₂₂FN₇O₂S 467.5 468 2 Int. 5 5,7-Dimethyl-pyrazolo[1,5- a]pyrimidine-3-carboxylic a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)- acid ureido]-thiazol-4-ylmethyl}- methyl-amide 176 3,5-Dimethyl-isoxazole-4- C₁₉H₂₀FN₅O₄S 433.5 434 3 Int. 24 3,5-Dimethyl-isoxazole-4- carboxylic acid (1-{2-[3-(3- carboxylic acid chloride fluoro-benzyl)-ureido]-thiazol- 4-yl}-2-hydroxy-ethyl)-amide 177 1-Methyl-1H-indole-3- C₂₃H₂₂FN₅O₂S 451.5 452 2 Int. 5 1-Methyl-1H-indole-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 178 1-Methyl-1H-indazole-3- C₂₂H₂₁FN₆O₂S 452.5 453 2 Int. 5 1-Methyl-1H-indazole-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 179 Pyrazolo[1,5-a]pyridine-3- C₂₁H₁₉FN₆O₂S 438.4 439 3 Int. 5 Pyrazolo[1,5-a]pyridine-3- carboxylic acid {2-[3-(3- carboxylic acid chloride fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 180 N-{2-[3-(3-Fluoro-benzyl)- C₁₉H₁₇FN₄O₄S 416.4 417 2 Int. 5 2-Furan-2-yl-2-oxoacetic acid ureido]-thiazol-4-ylmethyl}-2- furan-2-yl-N-methyl-2-oxo- acetamide 181 3,5-Dimethyl-isoxazole-4- C₁₉H₂₁N₅O₃S 399.5 400 8 Int.18 Benzylamine carboxylic acid [2-(3-benzyl- ureido)-thiazol-4-ylmethyl]- methyl-amide 182 3-Methyl-pyrazine-2- C₁₇H₁₇ClN₆O₂S₂ 436.9 437 8; 10 Int. 22 (5-Chlorothiophen-2-yl- carboxylic acid {2-[3-(5- methyl)(2,4- chloro-thiophen-2-ylmethyl)- dimethoxybenzyl)amine (per ureido]-thiazol-4-ylmethyl}- Method 13) methyl-amide 183 3,5-Dimethyl-isoxazole-4- C₂₂H₂₆FN₅O₃S 459.5 460 3 Int. 25 3,5-Dimethyl-isoxazole-4- carboxylic acid {2-[3-(3- carboxylic acid chloride fluoro-benzyl)-ureido]-5- isopropyl-thiazol-4-ylmethyl}- methyl-amide 184 5-Oxo-pyrrolidine-2- C₁₈H₂₀FN₅O₃S 405.4 406 2 Int. 5 5-Oxo-pyrrolidine-2- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 185 3-Methyl-pyrazine-2- C₁₇H₁₇ClN₆O₂S₂ 436.9 437 8 Int. 22 (5-Chlorothiophen-3- carboxylic acid {2-[3-(5- yl)methananmine chloro-thiophen-3-ylmethyl)- hydrochloride (Int. 37) ureido]-thiazol-4-ylmethyl}- methyl-amide 186 3,5-Dimethyl-isoxazole-4- C₂₀H₂₀F₃N₅O₃S 467.5 468 3 Int. 26 3,5-Dimethyl-isoxazole-4- carboxylic acid (2,2-difluoro- carboxylic acid chloride ethyl)-{2-[3-(3-fluoro- benzyl)-ureido]-thiazol-4- ylmethyl}-amide 187 4-Methyl-pyridazine-3- C₁₉H₁₉FN₆O₂S 414.5 415 2 Int. 5 4-Methylpyridazine-3- carboxylic acid {2-[3-(3- carboxylic acid (Int. 33) fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 188 5-Methyl-pyridazine-4- C₁₉H₁₉FN₆O₂S 414.5 415 2 Int 5 5-Methylpyridazine-4- carboxylic acid {2-[3-(3- carboxylc acid (Int. 32) fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 189 3-Amino-1H-pyrazole-4- C₁₇H₁₈FN₇O₂S 403.4 404 2 Int. 5 3-Amino-1H-pyrazole-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 190 3,6-Dimethoxy-pyridazine-4- C₂₀H₂₁FN₆O₄S 460.5 461 2 Int. 5 3,6-Dimethoxy-pyridazine-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 191 (3,5-Dimethyl-isoxazol-4- C₂₀H₂₂FN₅O₄S 447.5 448 3 Int. 61 Methyl chloroformate ylmethyl)-{2-[3-(3-fluoro- benzyl)-ureido]-thiazol-4- ylmethyl}-carbamic acid methyl ester 192 (R)-Tetrahydro-furan-2- C₁₆H₁₉ClN₄O₃S₂ 414.9 415 2 Int. 29 (R)-2-Tetrahydrofuroic acid carboxylic acid {2-[3-(5- chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 193 5-Methyl-pyridazine-4- C₁₇H₁₇ClN₆O₂S₂ 436.9 437 2 Int. 29 5-Methylpyridazine-4- carboxylic acid {2-[3-(5- carboxylc acid (Int. 32) chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 194 3,5-Dimethyl-1H-pyrazole-4- C₁₇H₁₉ClN₆O₂S₂ 439.0 439 2 Int. 29 3,5-Dimethyl-1H-pyrazole-4- carboxylic acid {2-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 195 5-Methyl-pyridazine-4- C₁₇H₁₇ClN₆O₂S₂ 436.9 437 2 Int. 30 5-Methylpyridazine-4- carboxylic acid {2-[3-(5- carboxylc acid (Int. 32) chloro-thiophen-3-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 196 Tetrahydro-furan-2-carboxylic C₁₆H₁₉ClN₄O₃S₂ 414.9 415 2 Int. 30 (R)-2-Tetrahydrofuroic acid acid {2-[3-(5-chloro-thiophen- 3-ylmethyl)-ureido]-thiazol-4- ylmethyl}-methyl-amide 197 3,5-Dimethyl-1H-pyrazole-4- C₁₇H₁₉ClN₆O₂S₂ 439.0 439 2 Int. 30 3,5-Dimethyl-1H-pyrazole-4- carboxylic acid {2-[3-(5- carboxylic acid chloro-thiophen-3-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 198 1,3,5-Trimethyl-1H-pyrazole- C₁₈H₂₁ClN₆O₂S₂ 453.0 453 2 Int. 30 1,3,5-Trimethyl-1H-pyrazole- 4-carboxylic acid {2-[3-(5- 4-carboxylic acid chloro-thiophen-3-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 199 3,6-Dichloro-pyridazine-4- C₁₈H₁₅Cl₂FN₆O₂S 469.3 469 2 Int. 5 3,6-Dichloro-pyridazine-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 200 3-Chloro-6-methoxy- C₁₉H₁₈ClFN₆O₃S 465.0 465 44 3,6-Dichloropyridazine-4- MeOH pyridazine-4-carboxylic acid carboxylic acid {2-[3-(3- {2-[3-(3-fluoro-benzyl)- fluoro-benzyl)-ureido]- ureido]-thiazol-4-ylmethyl}- thiazol-4-ylmethyl}-methyl- methyl-amide amide (EX# 199) 201 3,5-Dimethyl-isoxazole-4- C₁₉H₁₉F₂N₅O₃S 435.0 436 2 Int. 40 3,5-Dimethyl-isoxazole-4- carboxylic acid {5-fluoro-2- carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 202 (R)-Tetrahydro-furan-2- C₁₈H₂₀F₂N₄O₃S 410.0 411 2 Int. 40 (R)-Tetrahydro-furan-2- carboxylic acid {5-fluoro-2- carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 203 3,5-Dimethyl-pyridazine-4- C₂₀H₂₁FN₆O₂S 428.0 429 2 Int. 5 3,5-Dimethyl-pyridazine-4- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 204 N-{5-Fluoro-2-[3-(3-fluoro- C₁₅H₁₆F₂N₄O₂S 354.0 355 2 Int. 40 acetic acid benzyl)-ureido]-thiazol-4- ylmethyl}-N-methyl- acetamide 205 1-Methyl-3-trifluoromethyl- C₁₉H₁₈F₄N₆O₂S 470.0 471 2 Int. 5 1-Methyl-3-trifluoromethyl- 1H-pyrazole-4-carboxylic acid 1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 206 1,3,5-Trimethyl-1H-pyrazole- C₂₀H₂₂F₂N₆O₂S 448.0 449 2 Int. 40 1,3,5-Trimethyl-1H-pyrazole- 4-carboxylic acid {5-fluoro-2- 4-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 207 1,3,5-Trimethyl-1H-pyrazole- C₁₈H₂₁ClN₆O₂S₂ 453.0 453 2 Int. 29 1,3,5-Trimethyl-1H-pyrazole- 4-carboxylic acid {2-[3-(5- 4-carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 208 3-Chloro-6-hydroxy- C₁₈H₁₆ClFN₆O₃S 451.0 451 45 3-Chloro-6-methoxy- None pyridazine-4-carboxylic acid pyridazine-4-carboxylic {2-[3-(3-fluoro-benzyl)- acid {2-[3-(3-fluoro- ureido]-thiazol-4-ylmethyl}- benzyl)-ureido]-thiazol-4- methyl-amide ylmethyl}-methyl-amide (EX# 200) 209 2-Methyl-tetrahydro-furan-2- C₁₉H₂₃FN₄O₃S 406.5 408 2 Int. 5 2-Methyl-tetrahydro-furan-2- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 210 4-Chloro-1-methyl-1H- C₁₈H₁₈ClFN₆O₂S 437.0 437 2 Int. 5 4-Chloro-1-methyl-1H- pyrazole-3-carboxylic acid {2- pyrazole-3-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 211 5-Chloro-1-methyl-1H- C₁₈H₁₈ClFN₆O₂S 437.0 437 2 Int. 5 5-Chloro-1-methyl-1H- pyrazole-4-carboxylic acid {2- pyrazole-4-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 212 4-Chloro-2-methyl-2H- C₁₈H₁₈ClFN₆O₂S 437.0 437 2 Int. 5 4-Chloro-2-methyl-2H- pyrazole-3-carboxylic acid {2- pyrazole-3-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 213 4-Chloro-1H-pyrazole-3- C₁₇H₁₆ClFN₆O₂S 423.0 423/425 2 Int. 5 4-Chloro-1H-pyrazole-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 214 3,5-Dimethyl-isoxazole-4- C₂₀H₁₉FN₆O₃S 442.0 443 2 Int. 41 3,5-Dimethyl-isoxazole-4- carboxylic acid (cyano-{2-[3- carboxylic (3-fluoro-benzyl)-ureido]- thiazol-4-yl}-methyl)-methyl- amide 215 1-Methyl-3-trifluoromethyl- C₁₇H₁₆ClF₃N₆O₂S₂ 493.0 493 2 Int. 29 1-Methyl-3-trifluoromethyl- 1H-pyrazole-4-carboxylic acid 1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-thiazol-4- ylmethyl}-methyl-amide 216 1-Methyl-3-trifluoromethyl- C₁₉H₂₂ClN₅O₃S₂ 468.0 468 2 Int. 29 1-Methyl-3-trifluoromethyl- 1H-pyrazole-4-carboxylic acid 1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-thiazol-4- ylmethyl}-methyl-amide 217 1,3,6-Trimethyl-1H- C₂₁H₂₂ClN₇O₂S₂ 504.0 505 2 Int. 29 1,3,6-Trimethyl-1H- pyrazolo[3,4-b]pyridine-4- pyrazolo[3,4-b]pyridine-4- carboxylic acid {2-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 218 N-{2-[3-(5-Chloro-thiophen- C₁₉H₂₀ClN₅O₄S₃ 514.0 514 2 Int. 29 2-Methyl-5-sulfamoyl-benzoic 2-ylmethyl)-ureido]-thiazol-4- acid ylmethyl}-2,N-dimethyl-5- sulfamoyl-benzamide 219 1-Methyl-6-oxo-1,4,5,6- C₁₇H₁₉ClN₆O₃S₂ 455.0 455 2 Int. 29 1-Methyl-6-oxo-1,4,5,6- tetrahydro-pyridazine-3- tetrahydro-pyridazine-3- carboxylic acid {2-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 220 1-Phenyl- C₂₂H₂₃ClN₄O₂S₂ 475.0 475 2 Int. 29 1-Phenyl- cyclobutanecarboxylic acid cyclobutanecarboxylic acid {2-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-thiazol-4- ylmethyl}-methyl-amide 221 3-Methyl-4-oxo-3,4-dihydro- C₂₁H₂₃ClN₆O₃S₂ 503.0 503 2 Int. 29 3-Methyl-4-oxo-3,4-dihydro- phthalazine-1-carboxylic acid phthalazine-1-carboxylic acid {2-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-thiazol-4- ylmethyl}-methyl-amide 222 7-Chloro-benzo[1,3]dioxole- C₁₉H₁₈Cl₂N₄O₄S₂ 499.0 499 2 Int. 29 7-Chloro-benzo[1,3]dioxole-5- 5-carboxylic acid [2-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl]- methyl-amide 223 N-[2-[3-(5-Chloro-thiophen- C₁₉H₁₇ClN₃O₂S₂ 489.0 489 2 Int. 29 6-[1,2,4]triazol-1-yl-nicotinic 2-ylmethyl)-ureido]-thiazol-4- acid ylmethyl]-N-methyl-6- [1,2,4]triazol-1-yl- nicotinamide 224 1-(2-Methoxy-ethyl)-6-oxo- C₁₉H₂₁ClN₆O₄S₂ 497.0 497 2 Int. 29 1-(2-Methoxy-ethyl)-6-oxo- 1,6-dihydro-pyridazine-3- 1,6-dihydro-pyridazine-3- carboxylic acid {2-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 225 N-((2-(3-((5-chlorothiophen- C₁₇H₁₇ClN₆O₄S₂ 467.0 467 2 Int. 29 2-(2,4-dioxo-3,4- 2-yl)methyl)ureido)thiazol-4- dihydropyrimidin-1(2H)- yl)methyl)-2-(2,4-dioxo-3,4- yl)acetic acid dihydropyrimidin-1(2H)-yl)- N-methylacetamide 226 1,1-Dioxo- C₁₆H₁₉ClN₄O₄S₃ 463.0 463 2 Int. 29 1,1-Dioxo- tetrahydrothiophene-3- tetrahydrothiophene-3- carboxylic acid {2-[3-(5- carboxylic acid chlorothiophen-2-yl)methyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 227 6-chloro-N-((2-(3-(3- C₁₈H₁₆ClFN₆O₃S 451.0 Structure 51 3-Chloro-6-methoxy- None fluorobenzyl)ureido)thiazol-4- Confirmed pyridazine-4-carboxylic yl)methyl)-3-hydroxy-N- by acid {2-[3-(3-fluoro- methylpyridazine-4- 1H- benzyl)-ureido]-thiazol-4- carboxamide NMR ylmethyl}-methyl-amide (EX# 200) 228 5-chloro-N-((2-(3-(3- C₁₉H₂₀ClFN₆O₂S 451.0 451 2 Int. 5 N,1,3-trimethyl-1H-pyrazole- fluorobenzyl)ureido)thiazol-4- 4-carboxylic acid yl)methyl)-N,1,3-trimethyl- 1H-pyrazole-4-carboxamide 229 N-((2-(3-(3- C₂₁H₂₄FN₅O₃S 446.0 446 2 Int. 5 N,3-dimethylisoxazole-4- fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-5-isopropyl-N,3- dimethylisoxazole-4- carboxamide 230 3-cyano-N-((2-(3-(3- C₂₁H₁₉FN₆O₃S 454.0 455 2 Int. 5 3-cyano-2-hydroxy-6- fluorobenzyl)ureido)thiazol-4- methylisonicotinic acid yl)methyl)-2-hydroxy-N,6- dimethylisonicotinamide 231 6-chloro-N-((2-(3-(3- C₁₈H₁₆ClFN₆O₃S 451.0 451 2 Int. 5 6-chloro-3-oxo-2,3- fluorobenzyl)ureido)thiazol-4- dihydropyridazine-4- yl)methyl)-N-methyl-3-oxo- carboxylic acid 2,3-dihydropyridazine-4- carboxamide 232 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₂FN₇O₂S 468.0 468 2 Int. 5 1-methyl-5-(1H-pyrrol-1-yl)- ureido)thiazol-4-yl)methyl)- 1H-pyrazole-4-carboxylic acid N,1-dimethyl-5-(1H-pyrrol-1- yl)-1H-pyrazole-4- carboxamide 233 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₂FN₅O₄S₂ 492.0 492 2 Int. 5 N,2-dimethyl-5- ureido)thiazol-4-yl)methyl)- sulfamoylbenzoic acid N,2-dimethyl-5- sulfamoylbenzamide 234 N-((2-(3-(3-fluorobenzyl) C₂₄H₂₅FN₄O₂S 452.0 453 2 Int. 5 1-phenylcyclobutane ureido)thiazol-4-yl)methyl)-N- carboxylic acid methyl-1-phenylcyclobutane carboxamide 235 N-((2-(3-(3-fluorobenzyl) C₂₂H₁₉FN₆O₃S 466.0 467 2 Int. 5 4-oxo-3,4-dihydrophthalazine- ureido)thiazol-4-yl)methyl)-N- 1-carboxylic acid methyl-4-oxo-3,4- dihydrophthalazine-1- carboxamide 236 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₁FN₄O₄S 444.0 445 2 Int. 5 4,6-dimethyl-2-oxo-2H-pyran- ureido)thiazol-4-yl)methyl)- 5-carboxylic acid N,4,6-trimethyl-2-oxo-2H- pyran-5-carboxamide 237 7-chloro-N-((2-(3-(3- C₂₁H₁₈ClFN₄O₄S 477.0 477 2 Int. 5 7-chlorobenzo[1,3]dioxole-5- fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N-methylbenzo [1,3]dioxole-5-carboxamide 238 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₁FN₆O₄S₂ 480.0 481 2 Int. 5 1-methyl-4-sulfamoyl-1H- ureido)thiazol-4-yl)methyl)- pyrrole-2-carboxylic acid N,1-dimethyl-4-sulfamoyl- 1H-pyrrole-2-carboxamide 239 2-(5,7-dimethyl-[1,2,4] C₂₂H₂₃FN₈O₂S 482.0 483 2 Int. 5 2-(5,7-dimethyl-[1,2,4] triazolo[1,5-a]pyrimidin-6-yl)- triazolo[1,5-a]pyrimidin-6-yl) N-((2-(3-(3-fluorobenzyl) acetic acid ureido)thiazol-4-yl)methyl)-N- methylacetamide 240 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₁FN₆O₄S 484.0 485 2 Int. 5 3,6-dimethyl-4-oxo-3,4- ureido)thiazol-4-yl)methyl)- dihydrofuro[2,3-d]pyrimidine- N,3,6-trimethyl-4-oxo-3,4- 5-carboxylic acid dihydrofuro[2,3-d]pyrimidine- 5-carboxamide 241 N-((2-(3-(3-fluorobenzyl) C₂₁H₁₉FN₆O₃S₂ 486.0 487 2 Int. 5 5-methyl-4-oxo-3,4- ureido)thiazol-4-yl)methyl)- dihydrothieno[2,3- N,5-dimethyl-4-oxo-3,4- d]pyrimidine-6-carboxamide dihydrothieno[2,3- d]pyrimidine-6-carboxamide 242 2,2-difluoro-N-((2-(3-(3- C₂₁H₁₉F₃N₄O₂S 448.0 449 2 Int. 5 2,2-difluoro-N-methyl-2- fluorobenzyl)ureido)thiazol-4- phenylacetic acid yl)methyl)-N-methyl-2- phenylacetamide 243 N2-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₆O₄S 450.0 451 2 Int. 5 1-carbamoyl-4- ureido)thiazol-4-yl)methyl)-4- hydroxypyrrolidine-2- hydroxy-N2- carboxylic acid methylpyrrolidine-1,2- dicarboxamide 244 N-((2-(3-((5-chlorothiophen- C₂₁H₂₃ClN₆O₃S₂ 507.0 507 2 Int. 29 2-morpholinonicotinic acid 2-yl)methyl)ureido)thiazol-4- yl)methyl)-N-methyl-2- morpholinonicotinamide 245 N-((2-(3-((5-chlorothiophen- C₂₀H₁₇ClN₆O₃S₂ 489.0 489 2 Int. 29 4-oxo-3,4-dihydrophthalazine- 2-yl)methyl)ureido)thiazol-4- 1-carboxylic acid yl)methyl)-N-methyl-4-oxo- 3,4-dihydrophthalazine-1- carboxamide 246 N-((2-(3-((5-chlorothiophen- C₁₉H₁₉ClN₄O₄S₂ 467.0 467 2 Int. 29 4,6-dimethyl-2-oxo-2H-pyran- 2-yl)methyl)ureido)thiazol-4- 5-carboxylic acid yl)methyl)-N,4,6-trimethyl-2- oxo-2H-pyran-5-carboxamide 247 N-((2-(3-((5-chlorothiophen- C₁₇H₁₉ClN₆O₄S₃ 503.0 503 2 Int. 29 1-methyl-4-sulfamoyl-1H- 2-yl)methyl)ureido)thiazol-4- pyrrole-2-carboxylic acid yl)methyl)-N,1-dimethyl-4- sulfamoyl-1H-pyrrole-2- carboxamide 248 N-((2-(3-((5-chlorothiophen- C₂₀H₂₁ClN₈O₂S₂ 505.0 505 2 Int. 29 2-(5,7-dimethyl-[1,2,4] 2-yl)methyl)ureido)thiazol-4- triazolo[1,5-a]pyrimidin-6- yl)methyl)-2-(5,7-dimethyl- yl)acetic acid [1,2,4]triazolo[1,5- a]pyrimidin-6-yl)-N- methylacetamide 249 N-((2-(3-((5-chlorothiophen- C₁₉H₁₇ClN₆O₃S₃ 509.0 509 2 Int. 29 5-methyl-4-oxo-3,4- 2-yl)methyl)ureido)thiazol-4- dihydrothieno[2,3- yl)methyl)-N,5-dimethyl-4- d]pyrimidine-6-carboxylic oxo-3,4-dihydrothieno[2,3- acid d]pyrimidine-6-carboxamide 250 N-((2-(3-((5-chlorothiophen- C₂₂H₂₂ClFN₄O₂S₂ 493.0 493 2 Int. 29 1-(3-fluorophenyl) 2-yl)methyl)ureido)thiazol-4- cyclobutane carboxylic acid yl)methyl)-1-(3-fluorophenyl)- N-methylcyclobutane carboxamide 251 N-((2-(3-((5-chlorothiophen- C₁₉H₁₇ClF₂N₄O₂S₂ 471.0 471 2 Int. 29 2,2-difluoro-2-phenylacetic 2-yl)methyl)ureido)thiazol-4- acid yl)methyl)-2,2-difluoro-N- methyl-2-phenylacetamide 252 N-((2-(3-(3-fluorobenzyl) C₁₈H₁₆F₄N₆O₂S 456.0 457 2 Int. 5 5-(trifluoromethyl)-1H- ureido)thiazol-4-yl)methyl)-N- pyrazole-4-carboxylic acid methyl-5-(trifluoromethyl)- 1H-pyrazole-4-carboxamide 253 N-((2-(3-(3-fluorobenzyl) C₁₉H₁₈F₄N₆O₂S 470.0 472 2 Int. 5 1-methyl-5-(trifluoromethyl)- ureido)thiazol-4-yl)methyl)- 1H-pyrazole-4-carboxylic acid N,1-dimethyl-5- (trifluoromethyl)-1H- pyrazole-4-carboxamide 254 (S)-N-((2-(3-(3-fluorobenzyl) C₁₇H₂₁FN₄O₃S 380.0 381 2 Int. 5 (S)-2-methoxypropanoic acid ureido)thiazol-4-yl)methyl)-2- methoxy-N- methylpropanamide 255 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₁FN₄O₄S 420.0 421 2 Int. 5 3-methyl-5,6-dihydro-1,4- ureido)thiazol-4-yl)methyl)- dioxine-2-carboxylic acid N,3-dimethyl-5,6-dihydro-1,4- dioxine-2-carboxamide 256 (R)-N-((2-(3-(3-fluorobenzyl) C₁₈H₁₉FN₄O₄S 406.0 407 2 Int. 5 5-oxotetrahydrofuran-2- ureido)thiazol-4-yl)methyl)-N- carboxylic acid methyl-5-oxotetrahydrofuran- 2-carboxamide 257 5-chloro-N-((2-(3-((5- C₁₇H₁₈Cl₂N₆O₂S₂ 473.0 475 2 Int. 29 5-chloro-1,3-dimethyl-1H- chlorothiophen-2-yl) pyrazole-4-carboxylic acid methyl)ureido)thiazol-4-yl) methyl)-N,1,3-trimethyl-1H- pyrazole-4-carboxamide 258 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₁FN₆O₃S 432.0 433 2 Int. 5 1-methyl-6-oxo-1,4,5,6- ureido)thiazol-4-yl)methyl)- tetrahydropyridazine-3- N,1-dimethyl-6-oxo-1,4,5,6- carboxylic acid tetrahydropyridazine-3- carboxamide 259 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₁FN₆O₃S 480.0 481 2 Int. 5 3-methyl-4-oxo-3,4- ureido)thiazol-4-yl)methyl)- dihydrophthalazine-1- N,3-dimethyl-4-oxo-3,4- carboxylic acid dihydrophthalazine-1- carboxamide 260 N-((2-(3-((5-chlorothiophen- C₂₀H₂₀ClN₇O₂S₂ 490.0 490 2 Int. 29 1-methyl-5-(1H-pyrrol-1-yl)- 2-yl)methyl)ureido)thiazol-4- 1H-pyrazole-4-carboxylic acid yl)methyl)-N,1-dimethyl-5- (1H-pyrrol-1-yl)-1H-pyrazole- 4-carboxamide 261 N-((2-(3-((5-chlorothiophen- C₂₀H₁₉ClN₆O₄S₂ 507.0 507 2 Int. 29 3,6-dimethyl-4-oxo-3,4- 2-yl)methyl)ureido)thiazol-4- dihydrofuro[2,3-d]pyrimidine- yl)methyl)-N,3,6-trimethyl-4- 5-carboxylic acid oxo-3,4-dihydrofuro[2,3- d]pyrimidine-5-carboxamide 262 N-((2-(3-(3-fluorobenzyl) C₁₇H₂₁FN₄O₃S 380.0 381 2 Int. 5 3-methoxypropanoic acid ureido)thiazol-4-yl)methyl)-3- methoxy-N- methylpropanamide 263 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₅FN₆O₃S 460.0 461 2 Int. 5 1-(2-hydroxyethyl)-3,5- ureido)thiazol-4-yl)methyl)-1- dimethyl-1H-pyrazole-4- (2-hydroxyethyl)-N,3,5- carboxylic acid trimethyl-1H-pyrazole-4- carboxamide 264 (R)-N-((2-(3-(3-fluorobenzyl) C₁₇H₂₁FN₄O₃S 380.0 381 2 Int. 5 (R)-2-methoxypropanoic acid ureido)thiazol-4-yl)methyl)-2- methoxy-N- methylpropanamide 265 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₇FN₆O₃S 474.0 475 2 Int. 5 1-(2-methoxyethyl)-3,5- ureido)thiazol-4-yl)methyl)-1- dimethyl-1H-pyrazole-4- (2-methoxyethyl)-N,3,5- carboxylic acid (Int. 42) trimethyl-1H-pyrazole-4- carboxamide 266 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₃S 406.0 407 2 Int. 5 Tetrahydro-2H-pyran-2- ureido)thiazol-4-yl)methyl)-N- carboxylic acid (Int. 43) methyltetrahydro-2H-pyran-2- carboxamide 267 N-(cyano(2-(3-(3- C₂₀H₁₈FN₇O₂S 439.0 440 2 Int. 41 3-methylpyrazine-2- fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N,3- dimethylpyrazine-2- carboxamide 268 N-(cyano(2-(3-(3- C₁₉H₂₀FN₅O₃S 417.0 418 2 Int. 41 tetrahydrofuran-2-carboxylic fluorobenzyl)ureido)thiazol-4- acid yl)methyl)-N- methyltetrahydrofuran-2- carboxamide 269 N-((2-(3-((5-chlorothiophen- C₂₀H₁₉ClN₆O₃S₂ 491.0 492 2 Int. 29 3,6-dimethylisoxazolo[5,4- 2-yl)methyl)ureido)thiazol-4- b]pyridine-4-carboxylic acid yl)methyl)-N,3,6- trimethylisoxazolo[5,4- b]pyridine-4-carboxamide 270 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₄S 422.0 423 2 Int. 5 5-methoxy-tetrahydrofuran-2- ureido)thiazol-4-yl)methyl)-5- carboxylic acid (Int. 44) methoxy-N- methyltetrahydrofuran-2- carboxamide 271 N-((2-(3-(3-fluorobenzyl) C₂₄H₃₁FN₆O₃S 503.0 503 2 Int. 5 1-(4-methoxybutyl)-3,5- ureido)thiazol-4-yl)methyl)-1- dimethyl-1H-pyrazole-4- (4-methoxybutyl)-N,3,5- carboxylic acid (Int. 45) trimethyl-1H-pyrazole-4- carboxamide 272 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₉FN₆O₃S 488.0 489 2 Int. 5 1-(3-methoxypropyl)-3,5- ureido)thiazol-4-yl)methyl)-1- dimethyl-1H-pyrazole-4- (3-methoxypropyl)-N,3,5- carboxylic acid (Int. 46) trimethyl-1H-pyrazole-4- carboxamide 273 N-((5-fluoro-2-(3-(3- C₂₀H₂₀F₂N₆O₂S 446.0 447 2 Int. 40 3,5-dimethylpyridazine-4- fluorobenzyl)ureido)thiazol-4- carboxylic acid (Int. 50) yl)methyl)-N,3,5- trimethylpyridazine-4- carboxamide 274 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₅FN₆O₃S 484.0 485 2 Int. 5 2-morpholinonicotinic acid ureido)thiazol-4-yl)methyl)-N- methyl-2- morpholinonicotinamide 275 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₁FN₆O₃S 468.0 469 2 Int. 5 3,6-dimethylisoxazolo[5,4- ureido)thiazol-4-yl)methyl)- b]pyridine-4-carboxylic acid N,3,6-trimethylisoxazolo[5,4- b]pyridine-4-carboxamide 276 N-((2-(3-(3-fluorobenzyl) C₂₄H₂₄F₂N₄O₂S 470.0 471 2 Int. 5 1-(4-fluorophenyl) ureido)thiazol-4-yl)methyl)-1- cyclobutanecarboxylic acid (4-fluorophenyl)-N- methylcyclobutane carboxamide 277 1,1-Dioxo- C₁₈H₂₁FN₄O₄S₂ 440.0 441 2 Int. 5 1,1-Dioxo- tetrahydrothiophene-3- tetrahydrothiophene-3- carboxylic acid {2-[3-(3- carboxylic acid fluoro-benzyl)-ureido]-thiazol- 4-ylmethyl}-methyl-amide 278 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₃S 406.0 407 2 Int. 5 5-methyltetrahydrofuran-2- ureido)thiazol-4-yl)methyl)- carboxylic acid (int. 47) N,5-dimethyltetrahydrofuran- 2-carboxamide 279 N-((2-(3-(3-fluorobenzyl) C₁₈H₂₁FN₄O₃S 392.0 393 2 Int. 5 3-methyloxetane-3-carboxylic ureido)thiazol-4-yl)methyl)- acid (Int. 48) N,3-dimethyloxetane-3- carboxamide 280 5-chloro-N-((2-(3-(3- C₁₇H₁₆ClFN₆O₂S 423.0 423 2 Int. 5 1H-pyrazole-4-carboxylic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N-methyl-1H- pyrazole-4-carboxamide 281 (R)-N-((2-(3-(3- C₁₉H₂₃FN₄O₄S 422.0 423 2 Int. 5 (R)-2,2-dimethyl-1,3- fluorobenzyl)ureido)thiazol-4- dioxolane-4-carboxylic acid yl)methyl)-N,2,2-trimethyl- 1,3-dioxolane-4-carboxamide 282 (S)-N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₄S 422.0 423 2 Int. 5 (S)-2,2-dimethyl-1,3- ureido)thiazol-4-yl)methyl)- dioxolane-4-carboxylic acid N,2,2-trimethyl-1,3- dioxolane-4-carboxamide 283 N-(2-amino-1-(2-(3-(3- C₁₉H₂₄FN₅O₃S 421.0 422 46 N-(Cyano(2-(3-(3- Hydrogen fluorobenzyl)ureido)thiazol-4- fluorobenzyl)ureido)thiazol- yl)ethyl)-N- 4-yl)methyl)-N- methyltetrahydrofuran-2- methyltetrahydrofuran-2- carboxamide carboxamide (EX# 268) 284 (R)-N-((2-(3-((5- C₁₆H₁₉FN₄O₃S₂ 398.0 399 2 Int. 41 (R)-tetrahydrofuran-2- fluorothiophen-2-yl) carboxylic acid methyl)ureido)thiazol-4-yl) methyl)-N- methyltetrahydrofuran-2- carboxamide 285 3,6-dichloro-N-((2-(3-(3- C₁₉H₁₇Cl₂FN₆O₂S 483.4 483 3 Int. 5 3,6-dichloro-5- fluorobenzyl)ureido)thiazol-4- methylpyridazine-4-carboxylic yl)methyl)-N,5- chloride (Int. 49) dimethylpyridazine-4- carboxamide 286 N-((2-(3-(3-fluorobenzyl) C₂₀H₂₁FN₆O₃S 444.5 Structure 47 3-Chloro-6-methoxy- Trimethylaluminum ureido)thiazol-4-yl)methyl)-6- confirmed pyridazine-4-carboxylic methoxy-N,3- by acid {2-[3-(3-fluoro- dimethylpyridazine-4- 1H- benzyl)-ureido]-thiazol-4- carboxamide NMR ylmethyl}-methyl-amide (EX# 200) 287 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₄FN₇O₂S 482.0 482 2 Int. 5 1,3,6-trimethyl-1H- ureido)thiazol-4-yl)methyl)- pyrazolo[3,4-b]pyridine-4- N,1,3,6-tetramethyl-1H- carboxylic acid pyrazolo[3,4-b]pyridine-4- carboxamide 288 N-((2-(3-(3-fluorobenzyl) C₁₈H₁₈FN₇O₄S 447.0 448 2 Int. 5 1-methyl-5-nitro-1H-pyrazole- ureido)thiazol-4-yl)methyl)- 4-carboxylic acid N,1-dimethyl-5-nitro-1H- pyrazole-4-carboxamide 289 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₁FN₄O₃S 440.0 441 2 Int. 5 2,3-dihydrobenzofuran-2- ureido)thiazol-4-yl)methyl)-N- carboxylic acid methyl-2,3- dihydrobenzofuran-2- carboxamide 290 N-((2-(3-((5-chlorothiophen- C₂₀H₁₉ClN₄O₃S₂ 463.0 463 2 Int. 29 2,3-dihydrobenzofuran-2- 2-yl)methyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N-methyl-2,3- dihydrobenzofuran-2- carboxamide 291 N-((2-(3-(3-fluorobenzyl) C₁₉H₁₉FN₆O₃S 430.0 431 48 N-((2-(3-(3-fluorobenzyl) BBr3 ureido)thiazol-4-yl)methyl)-6- ureido)thiazol-4-yl)methyl)- hydroxy-N,3- 6-methoxy-N,3- dimethylpyridazine-4- dimethylpyridazine-4- carboxamide carboxamide (EX# 286) 292 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₅FN₆O₂S 468.0 469 2 Int. 5 2-(pyrrolidin-1-yl)nicotinic ureido)thiazol-4-yl)methyl)-N- acid methyl-2-(pyrrolidin-1-yl) nicotinamide 293 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₁FN₄O₃S₂ 460.0 461 2 Int. 5 4-oxo-4-(thiophen-2-yl) ureido)thiazol-4-yl)methyl)-N- butanoic acid methyl-4-oxo-4-(thiophen-2- yl)butanamide 294 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₃FN₄O₃S 454.0 455 2 Int. 5 3-benzoylpropionic acid ureido)thiazol-4-yl)methyl)-N- methyl-4-oxo-4- phenylbutanamide 295 2-(3-fluoro-4-methoxyphenyl)- C₂₂H₂₂F₂N₄O₃S 460.0 461 2 Int. 5 2-(3-fluoro-4-methoxyphenyl) N-((2-(3-(3-fluorobenzyl) acetic acid ureido)thiazol-4-yl)methyl)-N- methylacetamide 296 2-(3,4-dimethoxyphenyl)-N- C₂₃H₂₅FN₄O₄S 472.0 473 2 Int. 5 2-(3,4-dimethoxyphenyl)acetic ((2-(3-(3-fluorobenzyl) acid ureido)thiazol-4-yl)methyl)-N- methylacetamide 297 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₃FN₄O₄S 458.0 459 2 Int. 5 2-(4-(hydroxymethyl) ureido)thiazol-4-yl)methyl)-2- phenoxy)acetic acid (4-(hydroxymethyl)phenoxy)- N-methylacetamide 298 N-((2-(3-(3-fluorobenzyl) C₂₂H₂₃FN₄O₄S₂ 490.0 491 2 Int. 5 2-(3-(methylsulfonyl) ureido)thiazol-4-yl)methyl)-N- phenyl)acetic acid methyl-2-(3-(methylsulfonyl) phenyl)acetamide 299 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₀FN₅O₂S₃ 466.0 466 2 Int. 5 2-(2-mercapto-4-methylthiazol- ureido)thiazol-4-yl)methyl)-2- 5-yl)acetic acid (2-mercapto-4-methylthiazol- 5-yl)-N-methylacetamide 300 N-((2-(3-(3-fluorobenzyl) C₁₉H₁₆F₄N₄O₃S 456.0 457 2 Int. 5 5-(trifluoromethyl)furan-2- ureido)thiazol-4-yl)methyl)-N- carboxylic acid methyl-5-(trifluoromethyl) furan-2-carboxamide 301 (R)-N-((5-fluoro-2-(3-(3- C₁₇H₂₀F₂N₄O₃S 398.0 399 2 Int. 40 (R)-2-methoxypropanoic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-2-methoxy-N- methylpropanamide 302 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₀FN₇O₃S 445.0 446 50 3-(dimethylamino)-N-((2- BBr3 ureido)thiazol-4-yl)methyl)-6- (3-(3-fluorobenzyl)ureido) hydroxy-N-methyl-3- thiazol-4-yl)methyl)-6- (methylamino)pyridazine-4- methoxy-N- carboxamide methylpyridazine-4- carboxamide (EX# 303) 303 3-(dimethylamino)-N-((2-(3- C₂₁H₂₄FN₇O₃S 474.0 474 49 3-Chloro-6-methoxy- dimethylamine (3-fluorobenzyl) ureido) pyridazine-4-carboxylic thiazol-4-yl)methyl)-6- acid {2-[3-(3-fluoro- methoxy-N-methylpyridazine- benzyl)-ureido]-thiazol-4- 4-carboxamide ylmethyl}-methyl-amide (EX# 200) 304 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₃FN₆O₄S 474.0 475 2 Int. 5 1-(2-methoxyethyl)-6-oxo-1,6- ureido)thiazol-4-yl)methyl)-1- dihydropyridazine-3- (2-methoxyethyl)-N-methyl-6- carboxylic acid oxo-1,6-dihydropyridazine-3- carboxamide 305 N-((2-(3-((5-chlorothiophen- C₂₁H₂₃ClN₆O₂S₂ 491.0 491 2 Int. 29 2-(pyrrolidin-1-yl)nicotinic 2-yl)methyl)ureido)thiazol-4- acid yl)methyl)-N-methyl-2- (pyrrolidin-1-yl)nicotinamide 306 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₇FN₄O₃S 434.0 435 2 Int. 5 2,2-dimethyltetrahydro-2H- ureido)thiazol-4-yl)methyl)- pyran-4-carboxylic acid N,2,2-trimethyltetrahydro-2H- pyran-4-carboxamide 307 N-((2-(3-((5-chlorothiophen- C₁₉H₂₅ClN₄O₃S₂ 457.0 457 2 Int. 29 2,2-dimethyltetrahydro-2H- 2-yl)methyl)ureido)thiazol-4- pyran-4-carboxamide yl)methyl)-N,2,2- trimethyltetrahydro-2H-pyran- 4-carboxamide 308 N-((2-(3-((1H-indol-5- C₂₁H₂₂N₆O₃S 438.5 437 8 Int. 18 C-(1H-Indol-5-yl)- yl)methyl)ureido)thiazol-4- methylamine yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 309 N-((2-(3-(benzo[1,2,5] C₁₉H₁₉N₇O₄S 441.5 440 8 Int. 18 C-Benzo[1,2,5]oxadiazol-5-yl- oxadiazol-5-ylmethyl)ureido) methylamine thiazol-4-yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 310 N-((2-(3-(benzo[1,2,5] C₁₉H₁₉N₇O₃S₂ 457.5 456 8 Int. 18 C-Benzo[1,2,5]thiadiazol-5- thiadiazol-5-ylmethyl)ureido) yl-methylamine thiazol-4-yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 311 2-(4-(dimethylamino)phenyl)- C₂₃H₂₆FN₅O₂S 456.0 456 2 Int. 5 2-(4-(dimethylamino)phenyl) N-((2-(3-(3-fluorobenzyl) acetic acid ureido)thiazol-4-yl)methyl)-N- methylacetamide 312 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₄FN₅O₃S 470.0 470 2 Int. 5 7-hydroxy-1,2,3,4- ureido)thiazol-4-yl)methyl)-7- tetrahydroisoquinoline-3- hydroxy-N-methyl-1,2,3,4- carboxylic acid tetrahydroisoquinoline-3- carboxamide 313 3-(1H-benzoimidazol-2-yl)-N- C₂₃H₂₃FN₆O₂S 466.0 467 2 Int 5. 3-(1H-benzoimidazol-2- ((2-(3-(3-fluorobenzyl) yl)propanoic acid ureido)thiazol-4-yl)methyl)-N- methylpropanamide 314 N-((2-(3-(3-fluorobenzyl) C₂₅H₂₃FN₄O₂S 462.0 463 2 Int. 5 2-(naphthalen-2-yl)acetic acid ureido)thiazol-4-yl)methyl)-N- methyl-2-(naphthalen-2-yl) acetamide 315 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₅FN₄O₃S 456.0 457 2 Int. 5 2-(4-methoxy-3- ureido)thiazol-4-yl)methyl)-2- methylphenyl)acetic acid (4-methoxy-3-methylphenyl)- N-methylacetamide 316 2-amino-3-(benzyloxy)-N-((2- C₂₃H₂₆FN₅O₃S 472.0 472 2 Int. 5 2-amino-3-(benzyloxy) (3-(3-fluorobenzyl)ureido) propanoic acid thiazol-4-yl)methyl)-N- methylpropanamide 317 N-((2-(3-(3-fluorobenzyl) C₂₂H₁₉FN₆O₄S 482.0 483 2 Int. 5 1,4-dioxo-1,2,3,4- ureido)thiazol-4-yl)methyl)-N- tetrahydrophthalazine-6- methyl-1,4-dioxo-1,2,3,4- carboxylic acid tetrahydrophthalazine-6- carboxamide 318 N-((2-(3-(3-fluorobenzyl) C₂₁H₁₉FN₈O₂S 466.0 467 2 Int. 5 6-(1H-1,2,4-triazol-1-yl) ureido)thiazol-4-yl)methyl)-N- nicotinic acid methyl-6-(1H-1,2,4-triazol-1- yl)nicotinamide 319 2-(2,4-dioxo-3,4- C₁₉H₁₉FN₆O₄S 446.0 447 2 Int. 5 2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)- dihydropyrimidin-1(2H)-yl) N-((2-(3-(3-fluorobenzyl) acetic acid ureido)thiazol-4-yl)methyl)-N- methylacetamide 320 N-((2-(3-((5-chlorothiophen- C₂₀H₁₇ClN₆O₄S₂ 505.0 505 2 Int. 29 1,4-dioxo-1,2,3,4- 2-yl)methyl)ureido)thiazol-4- tetrahydrophthalazine-6- yl)methyl)-N-methyl-1,4- carboxylic acid dioxo-1,2,3,4- tetrahydrophthalazine-6- carboxamide 321 N2-((2-(3-((5-chlorothiophen- C₁₇H₂₁ClN₆O₄S₂ 473.0 473 2 Int. 29 1-carbamoyl-4- 2-yl)methyl)ureido)thiazol-4- hydroxypyrrolidine-2- yl)methyl)-4-hydroxy-N2- carboxylic acid methylpyrrolidine-1,2- dicarboxamide 322 N-((2-(3-((5-chlorothiophen- C₁₆H₁₆ClN₇O₄S₂ 470.0 470 2 Int. 29 1-methyl-5-nitro-1H-pyrazole- 2-yl)methyl)ureido)thiazol-4- 4-carboxylic acid yl)methyl)-N,1-dimethyl-5- nitro-1H-pyrazole-4- carboxamide 323 (S)-3,3-difluoro-N-((2-(3-(3- C₁₈H₁₉F₃N₄O₃S 428.0 429 2 Int. 5 (S)-3,3- fluorobenzyl)ureido)thiazol-4- difluorotetrahydrofuran-2- yl)methyl)-N- carboxylic acid methyltetrahydrofuran-2- carboxamide 324 N-((2-(3-(3-fluorobenzyl C₂₃H₂₃FN₄O₃S 454.0 455 2 Int. 5 Chroman-2-carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylchroman-2- carboxamide 325 4-(3,5-dimethyl-1H-pyrazol-4- C₂₅H₂₅FN₆O₂S 492.0 493 2 Int. 5 4-(3,5-dimethyl-1H-pyrazol-4- yl)-N-((2-(3-(3-fluorobenzyl) yl)benzoic acid ureido)thiazol-4-yl)methyl)-N- methylbenzamide 326 N-((2-(3-(3-fluorobenzyl) C₁₈H₁₉FN₄O₂S 374.0 375 2 Int. 5 Pent-4-ynoic acid ureido)thiazol-4-yl)methyl)-N- methylpent-4-ynamide 327 N-((2-(3-(3-fluorobenzyl) C₂₄H₂₆FN₅O₂S 468.0 468 2 Int. 5 2-methyl-1,2,3,4- ureido)thiazol-4-yl)methyl)- tetrahydroisoquinoline-3- N,2-dimethyl-1,2,3,4- carboxylic acid tetrahydroisoquinoline-3- carboxamide 328 (S)-2-amino-N-((2-(3-(3- C₂₁H₂₃FN₆O₂S 442.0 443 2; 6  Int. 5 N-Fmoc-(S)-2-amino-3- fluorobenzyl)ureido)thiazol-4- (pyridin-4-yl)propanoic acid yl)methyl)-N-methyl-3- (pyridin-4-yl)propanamide 329 cis-N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₄S 422.0 423 2 Int. 5 cis-3-methoxytetrahydrofuran- ureido)thiazol-4-yl)methyl)-3- 2-carboxylic acid (Int. 56) methoxy-N- methyltetrahydrofuran-2- carboxamide 330 1-cyano-N-((2-(3-(3- C₁₈H₁₈FN₅O₂S 387.0 388 2 Int. 5 1-cyanocyclopropane fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N- methylcyclopropane carboxamide 331 N-((2-(3-(3-fluorobenzyl) C₁₆H₁₅FN₄O₂S 346.0 347 2 Int. 5 propiolic acid ureido)thiazol-4-yl)methyl)-N- methylpropiolamide 332 N-((2-(3-(1H-indol-2- C₂₁H₂₂N₆O₃S 438.5 439 8 Int. 18 C-(1H-Indol-2-yl)- yl)methyl)ureido)thiazol-4- methylamine yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 333 N-((2-(3-(benzoxazol-6- C₂₀H₂₀N₆O₄S 440.5 439 8 Int. 18 C-Benzooxazol-6-yl- ylmethyl)ureido)thiazol-4- methylamine [Int. 57] yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 334 2-ethoxy-N-((2-(3-(3- C₁₈H₂₃FN₄O₃S 394.0 395 2 Int. 5 2-ethoxypropanoic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N- methylpropanamide 335 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₅FN₄O₄S 472.0 473 2 Int. 5 2-(4-methoxyphenoxy) ureido)thiazol-4-yl)methyl)-2- propanoic acid (4-methoxyphenoxy)-N- methylpropanamide 336 2-(cyclopropylmethoxy)-N- C₂₀H₂₅FN₄O₃S 420.0 421 2 Int. 5 2-(cyclopropylmethoxy) ((2-(3-(3-fluorobenzyl) propanoic acid ureido)thiazol-4-yl)methyl)-N- methylpropanamide 337 2,5-diamino-N-((2-(3-(3- C₁₈H₂₅FN₆O₂S 408.0 409 2; 1  Int. 5 N,N′-di-(tert-butoxylcarbony)- fluorobenzyl)ureido)thiazol-4- 2,5-diaminopentanoic acid yl)methyl)-N- methylpentanamide 338 N-((2-(3-(3-fluorobenzyl) C₂₄H₂₇FN₄O₄S 486.0 487 2 Int. 5 2-(2-phenoxyethoxy) ureido)thiazol-4-yl)methyl)-N- propanoic acid methyl-2-(2-phenoxyethoxy) propanamide 339 2-cyclopropyl-N-((2-(3-(3- C₁₈H₂₁FN₄O₂S 376.0 377 2 Int. 5 2-cyclopropylacetic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N- methylacetamide 340 N,3,5-trimethyl-N-((2-(3-(4- C₁₉H₂₀N₆O₅S 444.0 445 8 Int. 18 4-nitrobenzyl amine nitrobenzyl)ureido)thiazol-4- yl)methyl)isoxazole-4- carboxamide 341 N,3,5-trimethyl-N-((2-(3-(3- C₁₉H₂₀N₆O₅S 444.0 445 8 Int. 18 3-nitrobenzyl amine nitrobenzyl)ureido)thiazol-4- yl)methyl)isoxazole-4- carboxamide 342 3-ethyl-N-((2-(3-(3- C₁₉H₂₃FN₄O₃S 406.0 407 2 Int. 5 3-Ethyloxetane-3-carboxylic fluorobenzyl)ureido)thiazol-4- acid (Int. 55) yl)methyl)-N-methyloxetane- 3-carboxamide 343 2-(2,2-difluoroethoxy)-N-((2- C₁₈H₂₁F₃N₄O₃S 430.0 431 2 Int. 5 2-(2,2-difluoroethoxy) (3-(3-fluorobenzyl)ureido) propanoic acid thiazol-4-yl)methyl)-N- methylpropanamide 344 N-((2-(3-(3-fluorobenzyl) C₂₃H₂₄F₂N₄O₃S 474.0 475 2 Int. 5 2-(4-fluorobenzyloxy) ureido)thiazol-4-yl)methyl)-2- propanoic acid (4-fluorobenzyloxy) propanamide 345 2-(2,2,2-trifluoroethoxy)-N- C₁₈H₂₀F₄N₄O₃S 448.0 449 2 Int. 5 2-(2,2,2-trifluoroethoxy) ((2-(3-(3-fluorobenzyl)ureido) propanoic acid thiazol-4-yl)methyl)-N- methylpropanamide 346 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₁FN₄O₃S 404.0 405 2 Int. 5 2-(prop-2-ynyloxy)propanoic ureido)thiazol-4-yl)methyl)-2- acid (prop-2-ynyloxy)propanamide 347 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₄FN₅O₄S 462.0 462 2 Int. 5 2-((5-methylisoxazol-3- ureido)thiazol-4-yl)methyl)-N- yl)methoxy)propanamide methyl-2-((5-methylisoxazol- 3-yl)methoxy)propanamide 348 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₈FN₅O₃S 450.0 450 2 Int. 5 2-(1-methylpyrrolidin-3- ureido)thiazol-4-yl)methyl)-N- yloxy)propanoic acid methyl-2-(1-methylpyrrolidin- 3-yloxy)propanamide 349 N-((2-(3-(3-fluorobenzyl) C₁₈H₂₃FN₄O₄S 410.0 411 2 Int. 5 2-(2-hydroxyethoxy) ureido)thiazol-4-yl)methyl)-2- propanamide (2-hydroxyethoxy) propanamide 350 N-((2-(3-((5-chlorothiophen- C₁₇H₂₁ClN₄O₂S₂ 413.0 413 2 Int. 29 Cyclopentane carboxylic acid 2-yl)methyl)ureido)thiazol-4- yl)methyl)-N- methylcyclopentane carboxamide 351 N-((2-(3-((5-chlorothiophen- C₁₅H₁₇ClN₄O₃S₂ 401.0 401 2 Int. 29 1-hydroxycyclopropane 2-yl)methyl)ureido)thiazol-4- carboxylic acid yl)methyl)-1-hydroxy-N- methylcyclopropane carboxamide 352 N-((2-(3-((5-chlorothiophen- C₁₈H₂₃ClN₄O₂S₂ 427.0 427 2 Int. 29 Cyclohexane carboxylic acid 2-yl)methyl)ureido)thiazol-4- yl)methyl)-N- methylcyclohexane carboxamide 353 1-cyano-N-((5-fluoro-2-(3-(3- C₁₈H₁₇F₂N₅O₂S 405.0 406 2 Int. 5 1-cyanocyclopropane fluorobenzyl)ureido)thiazol-4- carboxylic acid yl)methyl)-N- methylcyclopropane carboxamide 354 N-((2-(3-(3-fluorobenzyl) C₁₉H₂₃FN₄O₂S 390.0 391 2 Int. 5 Cyclopentane carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylcyclopentane carboxamide 355 N-((2-(3-(3-fluorobenzyl) C₂₁H₂₇FN₄O₂S 418.0 419 2 Int. 5 2-methylcyclohexane ureido)thiazol-4-yl)methyl)- carboxylic acid N,2-dimethylcyclohexane carboxamide 356 N-((2-(3-(3-fluorobenzyl) C₂₀H₂₅FN₄O₂S 404.0 405 2 Int. 5 Cyclohexane carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylcyclohexane carboxamide 357 N-((2-(3-(3-fluorobenzyl) C₂₁H₁₈FN₅O₄S 455.0 456 2 Int. 5 2-oxo-2,3-dihydrobenzoxazole- ureido)thiazol-4-yl)methyl)-N- 6-carboxamide methyl-2-oxo-2,3- dihydrobenzoxazole-6- carboxamide 358 3,3,3-trifluoro-N-((2-(3-(3- C₁₆H₁₆F₄N₄O₂S 404.0 405 2 Int. 5 3,3,3-trifluoropropanoic acid fluorobenzyl)ureido)thiazol-4- yl)methyl)-N- methylpropanamide 359 N-((2-(3-(3-fluorobenzyl) C₁₇H₂₁FN₄O₃S 380.0 381 2 Int. 5 2-hydroxy-2-methylpropanoic ureido)thiazol-4-yl)methyl)-2- acid hydroxy-N,2- dimethylpropanamide 360 2,3-cis-N-((2-(3-(3- C₁₉H₂₃FN₄O₃S 406.0 407 2 Int. 5 cis-3-methyl-tetrahydrofuran- fluorobenzyl)ureido)thiazol-4- 2-carboxylic acid (Int. 54) yl)methyl)-N,3- dimethyltetrahydrofuran-2- carboxamide 361 (5R)-N-((2-(3-(3- C₁₉H₂₃FN₄O₄S 422.0 423 2; 11 Int. 5 (R)-5-(tert-Butyl-diphenyl- fluorobenzyl)ureido)thiazol-4- silanyloxymethyl)-tetrahydro- yl)methyl)-5-(hydroxymethyl)- furan-2-carboxylic acid (Int. N-methyltetrahydrofuran-2- 53) carboxamide 362 N-((2-(3-((5-chlorothiophen- C₁₅H₁₉ClN₄O₃S₂ 403.0 403 2 Int. 5 2-hydroxy-2-methylpropanoic 2-yl)methyl)ureido)thiazol-4- acid yl)methyl)-2-hydroxy-N,2- dimethylpropanamide 363 N-((2-(3-(5-chlorothiophen-2- C₁₉H₁₆ClN₅O₄S₂ 478.0 478 2 Int. 5 2-oxo-2,3-dihydrobenzoxazole- yl)methyl)ureido)thiazol-4- 6-carboxamide yl)methyl)-N-methyl-2-oxo- 2,3-dihydrobenzoxazole-6- carboxamide 364 (S)-N-((2-(3-((5- C₁₇H₂₀ClN₅O₄S₂ 458.0 458 2 Int. 5 (S)-2-(4-hydroxy-2- chlorothiophen-2- oxopyrrolidin-1-yl)acetic acid yl)methyl)ureido)thiazol-4- yl)methyl)-2-(4-hydroxy-2- oxopyrrolidin-1-yl)-N- methylacetamide 365 (R)-N-((2-(3-(benzo[1,2,5] C₁₈H₂₀N₆O₄S 416.0 417 7 Int. 52 2,1,3-Benzoxadiazole-5- oxadiazol-5-ylmethyl)ureido) methanamine hydrochloride thiazol-4-yl)methyl)-N- [RN 321330-19-2] methyltetrahydrofuran-2- carboxamide 366 (R)-N-((2-(3-((7-chlorobenzo C₁₉H₂₁ClN₄O₅S 453.0 453 7 Int. 52 5-Chloropiperonylamine (Int. [1,3]dioxol-5-yl)methyl) 66) ureido)thiazol-4-yl)methyl)-N- methyltetrahydrofuran-2- carboxamide 367 2,3,3,3-tetrafluoro-N-((2-(3- C₁₆H₁₅F₅N₄O₂S 422.0 423 2 Int. 5 2,3,3,3-tetrafluoropropanoic (3-fluorobenzyl)ureido) acid thiazol-4-yl)methyl)-N- methylpropanamide 368 N-((2-(3-(3-fluorobenzyl) C₁₇H₁₉FN₄O₂S 362.0 363 2 Int. 5 Cyclopropane carboxylic acid ureido)thiazol-4-yl)methyl)-N- methylcyclopropane carboxamide 369 N-((2-(3-(3-fluorobenzyl) C₁₈H₂₀FN₅O₃S 405.0 406 2 Int. 5 1-carbamoylcyclopropane ureido)thiazol-4-yl)methyl)-N- carboxylic acid methylcyclopropane-1,1- dicarboxamide 370 N-((2-(3-(3-fluorobenzyl) C₁₈H₂₁FN₄O₂S 376.0 377 2 Int. 5 2-methylcyclopropane ureido)thiazol-4-yl)methyl)- carboxylic acid N,2-dimethylcyclopropane carboxamide 371 (S)-N-((2-(3-(3-fluorobenzyl) C₁₉H₂₂FN₅O₄S 435.0 436 2 Int. 5 (S)-2-(4-hydroxy-2- ureido)thiazol-4-yl)methyl)-2- oxopyrrolidin-1-yl)acetic acid (4-hydroxy-2-oxopyrrolidin-1- yl)-N-methylacetamide

TABLE 2 Preparation of Thiadiazolyl Amides MOL MOL Starting EX# NAME FORMULA WEIGHT MASS METHOD Material 1 (SM1) Starting Material 2 (SM2) 372 N-((5-(3-(3-fluorobenzyl) C18H19FN6O3S 418.5 419 2 Int. 68 3,5-Dimethylisoxazole-4- ureido)-1,2,4-thiadiazol-3- carboxylic acid yl)methyl)-N,3,5- trimethylisoxazole-4- carboxamide 373 N-((5-(3-(3-fluorobenzyl) C21H22FN5O2S 427.5 428 2 Int. 68 2,6-Dimethylbenzoic acid ureido)-1,2,4-thiadiazol-3- yl)methyl)-N,2,6- trimethylbenzamide 374 N-((5-(3-(3-fluorobenzyl) C19H19FN6O2S 414.5 415 2 Int. 68 3-Methyl-nicotinic acid ureido)-1,2,4-thiadiazol-3- yl)methyl)-N,3- dimethylisonicotinamide 375 N-((5-(3-(3-fluorobenzyl) C18H18FN7O2S 415.5 416 2 Int. 68 3-Methylpyrazine-2- ureido)-1,2,4-thiadiazol-3- carboxylic acid yl)methyl)-N,3- dimethylpyrazine-2- carboxamide 376 1,3,5-Trimethyl-1H- C₁₉H₂₂FN₇O₂S 431.5 432 2 Int. 68 1,3,5-Trimethyl-1H-pyrazole- pyrazole-4-carboxylic acid 4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 377 5-Chloro-1,3-dimethyl-1H- C₁₈H₁₉ClFN₇O₂S 451.9 452 2 Int. 68 5-Chloro-1,3-dimethyl-1H- pyrazole-4-carboxylic acid pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 378 5-Isopropyl-3-methyl- C₂₀H₂₃FN₆O₃S 446.5 447 2 Int. 68 5-Isopropyl-3-methyl- isoxazole-4-carboxylic acid isoxazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 379 1,3,5-Trimethyl-1H-pyrazolo C₂₀H₂₁ClN₈O₂S₂ 505.0 505 2 Int. 69 1,3,5-Trimethyl-1H- [4,3-b]pyridine-7-carboxylic pyrazolo[4,3-b]pyridine-7- acid {5-[3-(5-chloro- carboxylic acid thiophen-2-ylmethyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 380 1-Methyl-5-pyrrol-1-yl-1H- C₂₁H₂₁FN₈O₂S 468.5 469 2 Int. 68 1-Methyl-5-pyrrol-1-yl-1H- pyrazole-4-carboxylic acid pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 381 3-Methyl-4-oxo-3,4-dihydro- C₂₂H₂₀FN₇O₃S 481.5 482 2 Int. 68 3-Methyl-4-oxo-3,4-dihydro- phthalazine-1-carboxylic acid phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 382 2,4-Dimethyl-6-oxo-6H- C₂₀H₂₀FN₅O₄S 445.5 446 2 Int. 68 2,4-Dimethyl-6-oxo-6H- pyran-3-carboxylic acid {5- pyran-3-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 383 3,6-Dimethyl-isoxazolo[5,4- C₂₁H₂₀FN₇O₃S 469.5 470 2 Int. 68 3,6-Dimethyl-isoxazolo[5,4- b]pyridine-4-carboxylic acid b]pyridine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 384 2-(5,7-Dimethyl-[1,2,4] C₂₁H₂₂FN₉O₂S 483.5 484 2 Int. 68 2-(5,7-Dimethyl-[1,2,4] triazolo[1,5-a]pyrimidin-6- triazolo[1,5-a]pyrimidin-6-yl)- yl)-N-{5-[3-(3-fluoro- acetic acid benzyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}-N- methyl-acetamide 385 3,6-Dimethyl-4-oxo-3,4- C₂₁H₂₀FN₇O₄S 485.5 486 2 Int. 68 3,6-Dimethyl-4-oxo-3,4- dihydro-furo[2,3- dihydro-furo[2,3- d]pyrimidine-5-carboxylic d]pyrimidine-5-carboxylic acid {5-[3-(3-fluoro-benzyl)- acid ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 386 N-{5-[3-(3-Fluoro-benzyl)- C₂₀H₁₈FN₉O₂S 467.5 468 2 Int. 68 [1,2,4]triazol-1-yl-nicotinic ureido]-[1,2,4]thiadiazol-3- acid ylmethyl}-N-methyl-6- [1,2,4]triazol-1-yl- nicotinamide 387 1-(2-Methoxy-ethyl)-6-oxo- C₂₀H₂₂FN₇O₄S 475.5 476 2 Int. 68 1-(2-Methoxy-ethyl)-6-oxo- 1,6-dihydro-pyridazine-3- 1,6-dihydro-pyridazine-3- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 388 1-Methyl-4-sulfamoyl-1H- C₁₆H₁₈ClN₇O₄S₃ 504.0 504 2 Int. 69 1-Methyl-4-sulfamoyl-1H- pyrrole-2-carboxylic acid {5- pyrrole-2-carboxylic acid [3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 389 N-{5-[3-(5-Chloro-thiophen- C₁₉H₂₀ClN₉O₂S₂ 506.0 506 2 Int. 69 (5,7-Dimethyl-[1,2,4]triazolo 2-ylmethyl)-ureido]-[1,2,4] [1,5-a]pyrimidin-6-yl)-acetic thiadiazol-3-ylmethyl}-2- acid (5,7-dimethyl-[1,2,4]triazolo [1,5-a]pyrimidin-6-yl)-N- methyl-acetamide 390 3,6-Dimethyl-4-oxo-3,4- C₁₉H₁₈ClN₇O₄S₂ 508.0 508 2 Int. 69 3,6-Dimethyl-4-oxo-3,4- dihydro-furo[2,3- dihydro-furo[2,3-d]pyrimidine- d]pyrimidine-5-carboxylic 5-carboxylic acid acid{5-[3-(5-chloro-thiophen- 2-ylmethyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 391 (R)-Tetrahydro-furan-2- C₁₇H₂₀FN₅O₃S 393.4 394 2; 10 Int. 70 (R)-Tetrahydro-furan-2- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 392 1,3,5-Trimethyl-1H-pyrazolo C₂₂H₂₃FN₈O₂S 482.5 483 2 Int. 68 1,3,5-Trimethyl-1H- [4,3-b]pyridine-7-carboxylic pyrazolo[4,3-b]pyridine-7- acid {5-[3-(3-fluoro-benzyl)- carboxylic acid ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 393 1-Methyl-3-trifluoromethyl- C₁₆H₁₅ClF₃N₇O₂S₂ 493.9 494 2 Int. 69 1-Methyl-3-trifluoromethyl- 1H-pyrazole-4-carboxylic 1H-pyrazole-4-carboxylic acid acid {5-[3-(5-chloro-thiophen- 2-ylmethyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 394 N-{5-[3-(5-Chloro-thiophen- C₁₈H₁₆ClN₇O₃S₂ 478.0 478 2 Int. 69 3-cyano-2-hydroxy-6,N- 2-ylmethyl)-ureido]-[1,2,4] dimethyl-isonicotinic acid thiadiazol-3-ylmethyl}-3- cyano-2-hydroxy-6,N- dimethyl-isonicotinamide 395 6-Chloro-3-oxo-2,3-dihydro- C₁₇H₁₅ClFN₇O₃S 451.9 452 2 Int. 68 6-Chloro-3-oxo-2,3-dihydro- pyridazine-4-carboxylic acid pyridazine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 396 1-Methyl-6-oxo-1,4,5,6- C₁₈H₂₀FN₇O₃S 433.5 434 2 Int. 68 1-Methyl-6-oxo-1,4,5,6- tetrahydro-pyridazine-3- tetrahydro-pyridazine-3- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 397 7-Chloro-benzo[1,3]dioxole- C₂₀H₁₇ClFN₅O₄S 477.9 478 2 Int. 68 7-Chloro-benzo[1,3]dioxole-5- 5-carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 398 5-Methyl-4-oxo-3,4-dihydro- C₂₀H₁₈FN₇O₃S₂ 487.5 488 2 Int. 68 5-Methyl-4-oxo-3,4-dihydro- thieno[2,3-d]pyrimidine-6- thieno[2,3-d]pyrimidine-6- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 399 1-Methyl-5-pyrrol-1-yl-1H- C₁₉H₁₉ClN₈O₂S₂ 491.0 491 2 Int. 69 1-Methyl-5-pyrrol-1-yl-1H- pyrazole-4-carboxylic acid pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 400 1-Methyl-6-oxo-1,4,5,6- C₁₆H₁₈ClN₇O₃S₂ 455.9 456 2 Int. 69 1-Methyl-6-oxo-1,4,5,6- tetrahydro-pyridazine-3- tetrahydro-pyridazine-3- carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 401 3-Methyl-4-oxo-3,4-dihydro- C₂₀H₁₈ClN₇O₃S₂ 504.0 504 2 Int. 69 3-Methyl-4-oxo-3,4-dihydro- phthalazine-1-carboxylic acid phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 402 2,4-Dimethyl-6-oxo-6H- C₁₈H₁₈ClN₅O₄S₂ 468.0 468 2 Int. 69 2,4-Dimethyl-6-oxo-6H- pyran-3-carboxylic acid {5- pyran-3-carboxylic acid [3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 403 5-Methyl-4-oxo-3,4-dihydro- C₁₈H₁₆ClN₇O₃S₃ 510.0 510 2 Int. 69 5-Methyl-4-oxo-3,4-dihydro- thieno[2,3-d]pyrimidine-6- thieno[2,3-d]pyrimidine-6- carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 404 N-{5-[3-(5-Chloro-thiophen- C₁₈H₁₆ClN₉O₂S₂ 490.0 490 2 Int. 69 6-[1,2,4]triazol-1-yl-nicotinic 2-ylmethyl)-ureido]-[1,2,4] acid thiadiazol-3-ylmethyl}-N- methyl-6-[1,2,4]triazol-1-yl- nicotinamide 405 1-(2-Methoxy-ethyl)-6-oxo- C₁₈H₂₀ClN₇O₄S₂ 498.0 498 2 Int. 69 1-(2-Methoxy-ethyl)-6-oxo- 1,6-dihydro-pyridazine-3- 1,6-dihydro-pyridazine-3- carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 406 N-{5-[3-(5-Chloro-thiophen- C₁₈H₁₆ClF₂N₅O₂S₂ 471.9 472 2 Int. 69 Difluoro-phenyl-acetic acid 2-ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}-2,2- difluoro-N-methyl-2-phenyl- acetamide 407 (R)-Tetrahydro-furan-2- C₁₇H₁₉N₇O₄S 417.5 418 2 Int. 3 2,1,3-Benzoxadiazole-5- carboxylic acid [5-(3- methanamine hydrochloride benzo[1,2,5]oxadiazol-5- [RN 321330-19-2] ylmethyl-ureido)- [1,2,4]thiadiazol-3- ylmethyl]-methyl-amide 408 3,5-Dimethyl-1H-pyrazole-4- C₁₈H₂₀FN₇O₂S 417.5 418 2; 10 Int. 70 3,5-Dimethyl-1H-pyrazole-4- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 409 3,5-Dimethyl-pyridazine-4- C₁₉H₂₀FN₇O₂S 429.5 430 2; 10 Int. 70 3,5-Dimethyl-pyridazine-4- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 410 5-Isopropyl-3-methyl- C₁₈H₂₁ClN₆O₃S₂ 469.0 469 2 Int. 69 5-Isopropyl-3-methyl- isoxazole-4-carboxylic acid isoxazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 411 N-{5-[3-(3-Fluoro-benzyl)- C₂₀H₂₁FN₆O₄S₂ 492.6 493 2 Int. 68 2-Methyl-5-sulfamoyl-benzoic ureido]-[1,2,4]thiadiazol-3- acid ylmethyl}-2,N-dimethyl-5- sulfamoyl-benzamide 412 1,1-Dioxo- C₁₇H₂₀FN₅O₄S₂ 441.5 442 2 Int. 68 1,1-Dioxo- tetrahydrothiophene-3- tetrahydrothiophene-3- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 413 N-{5-[3-(5-Chloro-thiophen- C₂₀H₂₂ClN₇O₃S₂ 508.0 508 2 Int. 69 2-Morpholin-4-yl-nicotinic 2-ylmethyl)-ureido]-[1,2,4] acid thiadiazol-3-ylmethyl}-N- methyl-2-morpholin-4-yl- nicotinamide 414 1-Phenyl-cyclobutane C₂₁H₂₂ClN₅O₂S₂ 476.0 476 2 Int. 69 1-Phenyl-cyclobutane carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 415 4-Oxo-3,4-dihydro- C₁₉H₁₆ClN₇O₃S₂ 490.0 490 2 Int. 69 4-Oxo-3,4-dihydro- phthalazine-1-carboxylic acid phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 416 7-Chloro-benzo[1,3]dioxole- C₁₈H₁₅Cl₂N₅O₄S₂ 500.4 500 2 Int. 69 7-Chloro-benzo[1,3]dioxole-5- 5-carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 417 1-(4-Fluoro-phenyl)- C₂₁H₂₁ClFN₅O₂S₂ 494.0 494 2 Int. 69 1-(4-Fluoro-phenyl)- cyclobutane carboxylic acid cyclobutanecarboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 418 1-Methyl-3-trifluoromethyl- C₁₈H₁₇F₄N₇O₂S 471.4 472 2 Int. 68 1-Methyl-3-trifluoromethyl- 1H-pyrazole-4-carboxylic 1H-pyrazole-4-carboxylic acid acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 419 5-Chloro-1,3-dimethyl-1H- C₁₆H₁₇Cl₂N₇O₂S₂ 474.4 474 2 Int. 69 5-Chloro-1,3-dimethyl-1H- pyrazole-4-carboxylic acid pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 420 1-Phenyl-cyclobutane C₂₃H₂₄FN₅O₂S 453.5 454 2 Int. 68 1-Phenyl-cyclobutane carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 421 4-Oxo-3,4-dihydro- C₂₁H₁₈FN₇O₃S 467.5 468 2 Int. 68 4-Oxo-3,4-dihydro- phthalazine-1-carboxylic acid phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 422 1-(4-Fluoro-phenyl)- C₂₃H₂₃F₂N₅O₂S 471.5 472 2 Int. 68 1-(4-Fluoro-phenyl)- cyclobutane carboxylic acid cyclobutanecarboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 423 2,2-Difluoro-N-{5-[3-(3- C₂₀H₁₈F₃N₅O₂S 449.5 450 2 Int. 68 Difluoro-phenyl-acetic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-N-methyl-2- phenyl-acetamide 424 1,1-Dioxo-tetrahydro- C₁₅H₁₈ClN₅O₄S₃ 464.0 464 2 Int. 69 1,1-Dioxo-tetrahydro- thiophene-3-carboxylic acid thiophene-3-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 425 2,2-Dimethyl-tetrahydro- C₁₈H₂₄ClN₅O₃S₂ 458.0 458 2 Int. 69 2,2-Dimethyl-tetrahydro- pyran-4-carboxylic acid {5- pyran-4-carboxylic acid [3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 426 2,3-Dihydro-benzofuran-2- C₂₁H₂₀FN₅O₃S 441.5 442 2 Int. 68 2,3-Dihydro-benzofuran-2- carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 427 (R)-Tetrahydro-furan-2- C₁₅H₁₈ClN₅O₃S₂ 415.9 416 2 Int. 69 (R)-Tetrahydro-furan-2- carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 428 2,2-Dimethyl-tetrahydro- C₂₀H₂₆FN₅O₃S 435.5 436 2 Int. 68 2,2-Dimethyl-tetrahydro- pyran-4-carboxylic acid {5- pyran-4-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 429 1-Methyl-5-nitro-1H- C₁₇H₁₇FN₈O₄S 448.4 449 2 Int. 68 1-Methyl-5-nitro-1H- pyrazole-4-carboxylic acid pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 430 1-Methyl-5-nitro-1H- C₁₅H₁₅ClN₈O₄S₂ 470.9 471 2 Int. 69 1-Methyl-5-nitro-1H-pyrazole- pyrazole-4-carboxylic acid 4-carboxylic acid {5-[3-(5-chloro-thiophen-2- ylmethyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}- methyl-amide 431 2,3-Dihydro-benzofuran-2- C₁₉H₁₈ClN₅O₃S₂ 464.0 464 2 Int. 69 2,3-Dihydro-benzofuran-2- carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 432 (R)—N-{5-[3-(3-Fluoro- C₁₆H₂₀FN₅O₃S 381.4 382 2; 10 Int. 70 (R)-2-Methoxy-propionic acid benzyl)-ureido]-[1,2,4] thiadiazol-3-ylmethyl}-2- methoxy-N-methyl- propionamide 433 (R)—N-{5-[3-(5-chloro- C₁₄H₁₈ClN₅O₃S₂ 403.9 404 2 Int. 69 (R)-2-Methoxy-propionic acid thiophen-2-ylmethyl)-ureido]- [1,2,4]thiadiazol-3- ylmethyl}-2-methoxy-N- methyl-propionamide 434 N-{5-[3-(3-Fluoro-benzyl)- C₂₂H₂₄FN₇O₃S 485.5 486 2 Int. 68 2-Morpholin-4-yl-nicotinic ureido]-[1,2,4]thiadiazol-3- acid ylmethyl}-N-methyl-2- morpholin-4-yl-nicotinamide 435 N-{5-[3-(3-Fluoro-benzyl)- C₂₂H₂₄FN₇O₂S 469.5 470 2 Int. 68 2-pyrrolidin-1-yl-nicotinic ureido]-[1,2,4]thiadiazol-3- acid ylmethyl}-N-methyl-2- pyrrolidin-1-yl-nicotinamide 436 N-{5-[3-(5-Chloro-thiophen- C₁₈H₁₉ClN₆O₄S₃ 515.0 515 2 Int. 69 2-Methyl-5-sulfamoyl-benzoic 2-ylmethyl)-ureido]-[1,2,4] acid thiadiazol-3-ylmethyl}-2,N- dimethyl-5-sulfamoyl- benzamide 437 N-{5-[3-(5-chloro-thiophen- C₂₀H₂₂ClN₇O₂S₂ 492.0 492 2 Int. 69 2-pyrrolidin-1-yl-nicotinic 2-ylmethyl)-ureido]-[1,2,4] acid thiadiazol-3-ylmethyl}-N- methyl-2-pyrrolidin-1-yl- nicotinamide 438 2,2-Difluoro-N-{5-[3-(3- C₁₉H₁₇F₃N₆O₂S 450.4 451 2; 10 Int. 70 Difluoro-pyridin-2-yl-acetic fluoro-benzyl)-ureido]- acid [1,2,4]thiadiazol-3-ylmethyl}- N-methyl-2-pyridin-2-yl- acetamide 439 1-Methyl-4-sulfamoyl-1H- C₁₈H₂₀FN₇O₄S₂ 481.5 482 2 Int. 68 1-Methyl-4-sulfamoyl-1H- pyrrole-2-carboxylic acid {5- pyrrole-2-carboxylic acid [3-(3-fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 440 4-Hydroxy-pyrrolidine-1,2- C₁₈H₂₂FN₇O₄S 451.5 452 2 Int. 68 4-Hydroxy-pyrrolidine-1- dicarboxylic acid 1-amide 2- carboxamide-2-carboxylic ({5-[3-(3-fluoro-benzyl)- acid ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide) 441 Cyclopentanecarboxylic acid C₁₈H₂₂FN₅O₂S 391.5 392 2 Int. 68 Cyclopentane carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 442 2-Methyl-cyclohexanecarboxylic C₂₀H₂₆FN₅O₂S 419.5 420 2 Int. 68 2-Methyl- acid {5-[3-(3- cyclohexanecarboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 443 Cyclohexanecarboxylic acid C₁₉H₂₄FN₅O₂S 405.5 406 2 Int. 68 Cyclohexanecarboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 444 2,6-Dioxo-hexahydro- C₁₇H₁₈FN₇O₄S 435.4 436 2 Int. 68 2,6-Dioxo-hexahydro- pyrimidine-4-carboxylic acid pyrimidine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 445 1-Cyano-cyclopropane C₁₅H₁₅ClN₆O₂S₂ 410.9 411 2 Int. 69 1-Cyano-cyclopropane carboxylic acid {5-[3-(5- carboxylic acid chloro-thiophen-2-ylmethyl)- ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 446 1-Hydroxy-cyclopropane C₁₆H₁₈FN₅O₃S 379.4 380 2 Int. 68 1-Hydroxy-cyclopropane carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 447 2-Oxo-2,3-dihydro- C₂₀H₁₇FN₆O₄S 456.5 457 2 Int. 68 2-Oxo-2,3-dihydro- benzooxazole-6-carboxylic benzooxazole-6-carboxylic acid {5-[3-(3-fluoro-benzyl)- acid ureido]-[1,2,4]thiadiazol-3- ylmethyl}-methyl-amide 448 N-{5-[3-(3-Fluoro-benzyl)- C₁₆H₂₀FN₅O₃S 381.4 382 2 Int. 68 2-Hydroxy-2-methyl- ureido]-[1,2,4]thiadiazol-3- propionic acid ylmethyl}-2-hydroxy-2,N- dimethyl-propionamide 449 1-Cyano-cyclopropane C₁₇H₁₇FN₆O₂S 388.4 389 2; 10 Int. 70 1-Cyano-cyclopropane carboxylic acid {5-[3-(3- carboxylic acid fluoro-benzyl)-ureido]- [1,2,4]thiadiazol-3-ylmethyl}- methyl-amide 450 N-{5-[3-(3-Fluoro-benzyl)- C₁₈H₂₁FN₆O₄S 436.5 437 2 Int. 68 ((S)-4-Hydroxy-2-oxo- ureido]-[1,2,4]thiadiazol-3- pyrrolidin-1-yl)-acetic acid ylmethyl}-2-((S)-4-hydroxy- 2-oxo-pyrrolidin-1-yl)-N- methyl-acetamide

TABLE 3 Preparation of Thiazolyl Sulfonamides MOL MOL Starting EX# NAME FORMULA WEIGHT MASS METHOD Material 1 (SM1) Starting Material 2 (SM2) 451 1,1-Dioxo-tetrahydro-1l6- C₁₇H₂₀C₁₂N₄O₅S₃ 527.5 527, 5 Int. 3 1,1-Dioxo- thiophene-3-sulfonic acid 529 tetrahydrothiophene-3- {2-[3-(3,4-dichloro-benzyl)- sulfonyl chloride ureido]-thiazol-4-ylmethyl}- methyl-amide 452 N-((2-(3-(3,4- C₂₀H₂₀C₁₂N₄O₃S₂ 499.4 499, 5 Int. 3 4-Toluenesulfonyl chloride dichlorobenzyl)ureido) 501 thiazol-4-yl)methyl)-N,4- dimethyl benzene sulfonamide 453 N-((2-(3-(3,4- C₁₈H₁₉C₁₂N₅O₄S₂ 504.4 504, 5 Int. 3 3,5-Dimethylisoxazole-4- dichlorobenzyl)ureido) 506 sulfonyl chloride thiazol-4-yl)methyl)-N,3,5- trimethylisoxazole-4- sulfonamide 454 N-((2-(3-(3,4- C₁₄H₁₆C₁₂N₄O₃S₂ 423.3 423 5 Int. 3 Methanesulfonyl chloride dichlorobenzyl)ureido) thiazol-4-yl)methyl)-N- methyl methane sulfonamide 455 N-((2-(3-(3-fluorobenzyl) C₁₄H₁₇FN₄O₃S₂ 372.4 373 5 Int. 5 Methanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-methylmethane sulfonamide 456 N-((2-(3-(3-fluorobenzyl) C₁₆H₂₁FN₄O₃S₂ 400.5 401 5 Int. 5 1-Propanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-methylpropane-1- sulfonamide 457 5-(2-(3-(3,4-dichlorobenzyl) C₁₈H₂₀C₁2N₄O₅S₂ 507.4 507, 5 Int. 58 Methanesulfonyl chloride ureido) thiazol-4-yl)-1- 509 (methylsulfonyl)pyrrolidin- 3-yl acetate 458 1-(3,4-dichlorobenzyl)-3-(4- C₁₆H₁₈C₁2N₄O₄S₂ 465.4 465, 20 5-(2-(3-(3,4- none (4-hydroxy-1- 467 dichlorobenzyl) (methylsulfonyl)pyrrolidin- ureido)thiazol-4- 2-yl)thiazol-2-yl)urea yl)-1-(methylsulfonyl)- pyrrolidin- 3-yl acetate (EX# 457) 459 N-((2-(3-(3-fluorobenzyl) C₁₇H₂₃FN₄O₃S₂ 414.5 415 5 Int. 5 1-Butanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-methylbutane-1- sulfonamide 460 N-((2-(3-(3-fluorobenzyl) C₁₅H₁₉FN₄O₃S₂ 386.5 387 5 Int. 5 Ethanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-methylethane sulfonamide 461 N-((2-(3-(3-fluorobenzyl) C₁₈H₂₀FN₅O_(4 S2) 453.5 454 5 Int. 5 3,5-Dimethylisoxazole-4- ureido)thiazol-4-yl)methyl)- sulfonyl chloride N,3,5-trimethylisoxazole-4- sulfonamide 462 N-((2-(3-(3-fluorobenzyl) C₁₆H₁₉FN4O₃S₂ 398.5 399 5 Int. 5 Cyclopropanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-methylcyclopropane sulfonamide 463 N-((2-(3-(3-fluorobenzyl) C₁₆H₂₂FN₅O_(5 S3) 479.6 481 5 Int. 59 Methanesulfonyl chloride ureido)thiazol-4-yl)methyl)- N-(2-(methylsulfonamido) ethyl)methane sulfonamide 464 1-[4-(1,1-Dioxo-1l6- C₁₅H₁₇FN₄O₃S₂ 384.5 385 16 Int. 21 Isothiazolidine 1,1-dioxide isothiazolidin-2-ylmethyl)- thiazol-2-yl]-3-(3-fluoro- benzyl)-urea 465 1-(3-Fluoro-benzyl)-3-{4- C₁₈H₂₃FN₄O₃S₂ 426.5 427 5 Int. 60 Propanesulfonyl chloride [1-(propane-1-sulfonyl)- pyrrolidin-2-yl]-thiazol-2- yl}-urea 466 Ethanesulfonic acid {5- C₁₅H₁₈BrFN₄O₃S₂ 465.4 465 17 N-((2-(3-(3- Bromine bromo-2-[3-(3-fluoro- fluorobenzyl) benzyl)-ureido]-thiazol-4- ureido)thiazol- ylmethyl}-methyl-amide 4-yl)methyl)-N- methylethane- sulfonamide (EX# 460) 467 N-{2-[3-(3-Fluoro-benzyl)- C₂₃H₂₆FN₅O₄S₂ 519.6 521 5 Int. 5 4-Morpholin-4-yl- ureido]-thiazol-4-ylmethyl}- benzenesulfonyl chloride N-methyl-4-morpholin-4-yl- benzenesulfonamide 468 Furan-2-sulfonic acid {2-[3- C₁₇H₁₇FN₄O₄S₂ 424.5 425 5 Int. 5 Furan-2-sulfonyl chloride (3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 469 Thiophene-2-sulfonic acid C₁₇H₁₇FN₄O₃S₃ 440.5 441 5 Int. 5 Thiophene-2-sulfonyl chloride {2-[3-(3-fluoro-benzyl)- ureido]-thiazol-4-ylmethyl}- methyl-amide 470 Pyridine-3-sulfonic acid {2- C₁₈H₁₈FN₅O₃S₂ 435.5 436 5 Int. 5 Pyridine-3-sulfonyl chloride [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 471 Pyridine-2-sulfonic acid {2- C₁₈H₁₈FN₅O₃S₂ 435.5 436 5 Int. 5 Pyridine-2-sulfonyl chloride [3-(3-fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 472 1-Methyl-1H-imidazole-4- C₁₇H₁₉FN₆O₃S₂ 438.5 439 5 Int. 5 1-Methyl-1H-imidazole-4- sulfonic acid {2-[3-(3- sulfonyl chloride fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 473 1,2-Dimethyl-1H-imidazole- C₁₈H₂₁FN₆O₃S₂ 452.5 453 5 Int. 5 1,2-Dimethyl-1H-imidazole-4- 4-sulfonic acid {2-[3-(3- sulfonyl chloride fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}-methyl- amide 474 N-{2-[3-(3-Fluoro-benzyl)- C₁₉H₂₀FN₅O₃S₂ 449.5 450 5 Int. 5 Pyridin-3-yl-methanesulfonyl ureido]-thiazol-4-ylmethyl}- chloride N-methyl-C-pyridin-3-yl- methanesulfonamide 475 N-(3,5-Dimethyl-isoxazol- C₁₉H₂₂FN₅O₄S₂ 467.5 468 5 Int. 61 Methanesulfonyl chloride 4-ylmethyl)-N-{2-[3-(3- fluoro-benzyl)-ureido]- thiazol-4-ylmethyl}- methane sulfonamide

Example 476 Intermediates Intermediate 1: 4-(Chloromethyl)thiazol-2-amine hydrochloride

To a solution of 1,3-dichloroacetone (150 g, 1.18 mol) in acetone (600 mL) was added a solution of thiourea (91.7 g, 1.23 mol) in acetone (3000 mL). The mixture was stirred overnight at room temperature. The resulting suspension was concentrated to dryness in vacuo. Ethanol (1.2 L) was added and the mixture was stirred for 3 h. The insolubles were removed by filtration and the filtrate was concentrated to 500 mL. Heptanes (1.5 L) were slowly added resulting in the formation of a white precipitate. This was isolated by filtration, washed with heptane and dried in vacuo to afford 4-(chloromethyl)thiazol-2-amine hydrochloride as a white solid (141.3 g, 0.76 mol, 64%). ¹H NMR (DMSO-d₆): δ 9.50 (bs, 2H); 7.00 (s, 1H); 4.68 (s, 2H).

Alternative Process for Intermediate 1: A mixture of 1,3-dichloroacetone (380.9 g, 3 mol), thiourea (228.3 g, 3 mol), and isopropanol (3.6 L) was stirred at 40° C. under an inert atmosphere, affording a clear solution. The product crystallized after stirring overnight at room temperature. After cooling to −20° C., the product was isolated by filtration, washed with cold isopropanol (0.4 L), and dried in vacuo to afford the title compound as white crystals (408 g, 73.5% yield).

Intermediate 2: 1-(3,4-Dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl) urea

To a suspension of 4-(chloromethyl)thiazol-2-amine hydrochloride (7.55 g, 41 mmol) in DCM (150 mL) at 0° C. was added 3,4-dichlorobenzyl isocyanate (8.27 g, 41 mmol). A solution of DIPEA in DCM (30 mL) was added over a period of 30 minutes and the mixture was stirred overnight at room temperature. Evaporation of the volatiles followed by purification by column chromatography (EtOAc/heptanes 1/1) afforded 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea as an off-white solid (10.5 g, 30 mmol) in 73% yield. ¹H NMR (DMSO-d₆): δ 10.80 (bs, 1H); 7.60 (d, 1H); 7.55 (s, 1H); 7.11 (t, 1H); 7.05 (s, 1H); 4.63 (s, 2H); 4.30 (d, 2H).

Intermediate 3: 1-(3,4-Dichlorobenzyl)-3-(4-((methylamino)methyl)thiazol-2-yl)urea

A solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea and excess methylamine (2.0 M solution in tetrahydrofuran) was heated for 15 minutes at 60° C. under microwave irradiation. The volatiles were removed in vacuo and the product was purified by column chromatography (DCM/0-15% NH₃ saturated MeOH) to afford the title compound.

Intermediate 4: 1-(4-(Chloromethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea

Prepared by same procedure described for Intermediate 2 with 4-(chloromethyl)thiazol-2-amine hydrochloride and 3-fluorobenzyl isocyanate. ¹H-NMR (ppm, DMSO-d₆): 10.70 (bs, 1H), 7.36 (dd, 1H), 7.07 (m, 4H), 4.63 (s, 2H), 4.34 (d, 2H).

Alternative process for Intermediate 4 Using Carbonyl Diimidazole:

A stirred mixture of Intermediate 1: 2-amino-4-chloromethyl-thiazole hydrochloride (27.8 g, 0.15 mol), carbonyl diimidazole (25.5 g, 0.157 mol), and anhydrous THF (0.2 L) was treated dropwise with a solution of DIPEA (26.2 mL, 0.15 mol) in THF (20 mL) at 20-30 C. After 2-3 hours stirring, a solution of 3-fluorobenzylamine (18.5 mL, 0.164 mol) in THF (40 mL) was added. The reaction was diluted with water (200 mL) and THF was evaporated under reduced pressure. The residue was extracted with DCM (2×200 mL). The combined extracts were dried over sodium sulfate and concentrated to leave an orange resin that was purified by silica gel chromatography (acetone/hexane) to afford Intermediate 4 as a pale yellow solid (26 g, 58% yield).

Intermediate 5: 1-(3-Fluorobenzyl)-3-(4-((methylamino)methyl)thiazol-2-yl) urea

Prepared by reaction of Intermediate 4 with methylamine, following the procedure described for Intermediate 3.

Alternative Process for Intermediate 5 Using N,O-Dimethylhydroxylamine:

Step 1: 2-(3-(3-Fluorobenzyl)ureido)-4-(N-methoxy-N-methyl-aminomethyl)-thiazole. A mixture of Intermediate 4: 2-(3-(3-fluorobenzyl)ureido)-4-chloromethyl-thiazole (40 g, 0.133 mol), N,O-dimethylhydroxylamine (80 g, 0.820 mol), sodium carbonate (40 g, 0.754 mol), and abs. EtOH (0.2 L) was stirred and heated at 60-70 C for 8-12 hours. The mixture was diluted with water (0.8 L) and cooled to 20 C with continued stirring. The solids were collected by filtration, washed with water, and dried in vacuo to afford the title compound (37 g, 86% yield).

Step 2: Zinc Reduction of methoxyamine to amine (J. Natural Products 53(4), 995-999 (1990)). A solution of 2-(3-(3-fluorobenzyl)ureido)-4-(N-methoxy-N-methyl-aminomethyl)-thiazole (10.1 g, 31.1 mmol) in glacial HOAc (140 mL) was treated with micronized zinc dust (50 g) and the mixture was heated to 60-65 C with vigorous agitation. The reduction was complete in 2-16 hours and water (140 mL) was added. The mixture was filtered on Celite, the filter cake was reslurried in 1:1 HOAC:water (150 mL) and refiltered. The combine filtrate was made alkaline to pH 10 with NH₄OH and cooled in ice. The solids were collected by filtration, washed with water, and dried in vacuo to afford Intermediate 5 as an off-white solid (8.2 g, 89% yield). This product could be used directly or further purified by crystallization as the hydrochloride salt (1:1 MeOH:EtOH).

Intermediate 6: 1-(3,4-Dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea

To a solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea (Intermediate 2, 1 eq) in acetone was added sodium iodide (10 eq) at once. The mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo and the mixture was taken up in water and EtOAc. The layers were separated and the organic phase was washed with water and brine, dried over Na₂SO₄, and concentrated in vacuo to afford 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea as a tan-colored solid.

Intermediate 7: 1-(3-Fluorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl) urea

Prepared in a similar manner as 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea. ¹H-NMR (ppm, CDCl₃): 7.27 (m, 1H), 7.10 (m, 2H), 6.95 (t, 1H), 6.75 (s, 1H), 4.50 (d, 2H), 4.35 (s, 2H).

Intermediate 8: 1-(3,4-Dichlorobenzyl)-3-(4-((ethylamino)methyl)thiazol-2-yl)urea

The 1-(3,4-dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea (Intermediate 6, 0.3 mmol) was taken up in a 2.0 M solution of ethylamine in tetrahydrofuran (5 ml). Reaction was stirred at room temperature for 1 hour. The volatiles were removed in vacuo and the crude title compound was taken on as is, ˜75% pure.

Intermediate 9: 1-(3,4-Dichlorobenzyl)-3-(4-((isopropylamino)methyl)thiazol-2-yl)urea

The 1-(3,4-Dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea intermediate (0.3 mmol) was taken up in tetrahydrofuran (5 ml) and isopropyl amine (20 eq.) was added. The reaction was stirred overnight at room temperature. Added a saturated solution of NaSO₃ (40 ml). Extracted this with EtOAc twice. The combined organic extracts were dried over Na₂SO₄, filtered and solvent removed in vacuo. The crude 1-(3,4-dichlorobenzyl)-3-(4-((isopropylamino)methyl)thiazol-2-yl)urea was used as is.

Intermediate 10a: 1-(3,4-Dichlorobenzyl)-3-(4-(1-(methylamino)ethyl)thiazol-2-yl)urea

Step 1: The commercial starting material ethyl 2-aminothiazole-4-carboxylate (2 mmol) was dissolved in NMP and DIEA (1 equivalent) was added followed by addition of the 3,4-dichloro-benzyl isocyanate (1 equivalent). Add 5% DMAP. Heat at 160° C. under microwave irradiation for 30 min Added additional isocyanate reagent (1.0 eq) and microwave for another 30 minutes at 160° C. to obtain ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate in >90% conversion.

Step 2: Hydrolysis with NaOH to give 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid.

Step 3: Method 2 is followed to couple the above acid with N,O-dimethylhydroxylamine HCl salt to give 2-(3-(3,4-dichlorobenzyl)ureido)-N-methoxy-N-methylthiazole-4-carboxamide.

Step 4: 1 mmol of 2-(3-(3,4-dichlorobenzyl)ureido)-N-methoxy-N-methylthiazole-4-carboxamide was suspended in 10 ml dry tetrahydrofuran and cooled to 0 C. 1.5 ml of 3 M methylmagnesium chloride in tetrahydrofuran was added and stirred for 2 hours. The solution was poured in to 20 ml of 5% concentrate HCl in ethanol. The solution was diluted with brine and the precipitate was filtered, washed with water and dried.

Step 5: 156 mg of 1-(4-acetylthiazol-2-yl)-3-(3,4-dichlorobenzyl)urea was dissolved in 5 ml of 2 M methylamine solution in tetrahydrofuran. To the solution, 2.0 eq. of sodium triacetoxyborohydride was added and stirred overnight at room temp. The volatile was removed by evaporation and the residue was purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM to give the title compound.

Intermediate 10b: 1-(3-Fluorobenzyl)-3-(4-(1-(methylamino)ethyl)thiazol-2-yl)urea

The 1-(3-fluorobenzyl)-3-(4-(1-(methylamino)ethyl)thiazol-2-yl)urea was prepared following the same procedure described for Intermediate 10a using 3-fluoro-benzyl isocyanate in step one.

Intermediate 11: 1-(3,4-Dichlorobenzyl)-3-(4-((2,4-dimethoxybenzylamino) methyl)thiazol-2-yl) urea

1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea (Intermediate 6) was taken up in tetrahydrofuran and an excess of the 2,4-dimethoxy-benzylamine (20 eq.) was added. The reaction was allowed to stir overnight at room temperature. The volatiles were removed in vacuo. Resulting oil triturated with water to give a gooey solid. Water was decanted off and resulting residue was purified by column chromatography using 0-8% gradient of 7 N ammonia/MeOH and DCM to give 1-(3,4-Dichloro-benzyl)-3-{4-[(2,4-dimethoxy-benzylamino)-methyl]-thiazol-2-yl}-urea.

Intermediate 12: 1-(3,4-Dichlorobenzyl)-3-(4-((2-methoxyethylamino)methyl)thiazol-2-yl)urea

1-(4-Chloromethyl-thiazol-2-yl)-3-(3,4-dichloro-benzyl)-urea (Intermediate 2, 1 eq.) was taken up in NMP (0.3 M) and methoxyethylamine (2.2 eq.) was added. The reaction was heated overnight at 80° C. An aqueous workup was performed. The crude title compound was purified by column chromatography using 0-8% gradient of 7 N ammonia/MeOH and DCM.

Intermediate 13: 2-(2-(3-(3,4-Dichlorobenzyl)ureido)thiazol-4-yl)-N-methyl-2-(methylamino)acetamide

Step 1: Ethyl 2-(2-aminothiazol-4-yl)-2-oxoacetate (2.0 mmol) was dissolved in NMP (5 ml) and 3,4-dichlorobenzylisocyanate (2.0 eq.) was added and heated at 130 C under microwave irradiation for 30 minutes. The reaction solution was poured into water. The Ethyl 2-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-oxoacetate precipitate was filtered, washed with water and tetrahydrofuran and dried.

Step 2: Ethyl 2-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-oxoacetate (800 mg) was dissolved in 2 M methylamine in tetrahydrofuran (20 ml) and NaCNBH₃ (2.2 eq.) was added and stirred at room temperature overnight. The title compound was purified by column using 0-10% gradient of 7 N ammonia/MeOH and DCM.

Intermediate 14: 1-(3,4-dichlorobenzyl)-3-(4-((2-hydroxyethylamino)methyl)thiazol-2-yl)urea

1-(3,4-Dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea (Intermediate 6, 0.3 mmol) was taken up in tetrahydrofuran (5 ml) and 2-Amino-ethanol (20 eq.) was added. The reaction was stirred overnight at room temperature. Added a saturated solution of NaSO₃ (40 ml). Extracted this with EtOAc twice. The combined organic extracts were dried over Na₂SO₄, filtered and solvent removed in vacuo to give the title compound a solid.

Intermediate 15: tert-Butyl 2-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methylamino)ethylcarbamate

Step 1: Preparation of 2-(3-(3-fluorobenzyl)ureido)thiazole-4-carboxylate according to the procedure described for Intermediate 10b, step 1 and step 2.

Step 2: 2-(3-(3-fluorobenzyl)ureido)thiazole-4-carboxylate (4.08 mmol) is taken up in THF and solution is cooled to −78° C. Added LiAlH₄ (2.6 equivalents, 1M solution in THF). Stir at ambient temperature for 3 hours. Add slowly Na₂SO₄.10H₂O (6.4 g), then NaHSO₄ (1.8 g). Stir for 30 hours. Aqueous workup with EtOAc. Crystallized from DCM/hexanes to give 1-(3-fluorobenzyl)-3-(4-(hydroxymethyl)thiazol-2-yl)urea in 79% yield.

Step 3: The 1-(3-fluorobenzyl)-3-(4-(hydroxymethyl)thiazol-2-yl) urea is taken up in DCM and cooled to 0° C. and Dess-Martin oxidant (1.1 equiv) was added. Stirred at ambient temperature for 1 hour. Washed with dilute Na₂SO₃. Removed solvent in vacuo to give 1-(3-fluorobenzyl)-3-(4-formylthiazol-2-yl)urea (used directly in next step).

Step 4: Reductive amination with tert-butyl 2-aminoethylcarbamate (1.5 equiv) and the aldehyde (1.0 equiv) described in the previous step. The two are combined in DCM and cooled to 0° C., and NaBH(OAc)₃ (2.0 equiv) is added. Stirred at 0° C. for 1 hour. Quenched with dilute NaHCO₃. Purified by column chromatography with a gradient of 2-5% MeOH in DCM to give the title compound.

Intermediate 16: tert-Butyl 4-(chloromethyl)thiazol-2-ylcarbamate

To a solution of N-Boc-thiourea (3.0 g, 17 mmol) in acetone (75 mL) was added 1,3-dichloroacetone (2.4 g, 18.7 mmol) at once. The mixture was stirred at room temperature for 72 h. The reaction mixture was treated with 3 g of NaHCO₃ and stirred for 15 min. The solids were removed by filtration and the filtrate was concentrated in vacuo. Column chromatography (EtOAc/Heptanes 4/1) afforded N-Boc-4-(chloromethyl)thiazol-2-amine (2.9 g, 11.6 mmol, 68%) as a white solid.

Intermediate 17: tert-Butyl 4-((methylamino)methyl)thiazol-2-ylcarbamate

tert-Butyl 4-(chloromethyl)thiazol-2-ylcarbamate (8.0 g, 24.16 mmol) was dissolved in 2.0 M methylamine in tetrahydrofuran (640 mL, ˜40 eq.) and heated in the microwave for 60 minutes at 60° C. The precipitate (impurity) was filtered off and the filtrate was concentrated under reduced pressure to furnish 1.97 g product as orange foam. ¹H NMR (DMSO-d₆): δ 11.79 (s, br, 1H), 7.50 (s, 1H), 7.36 (d, 1H), 7.10 (m, 2H), 5.14 (s, br, 1H), 4.63 (s, 2H), 4.36 (s, 2H), 3.83 (t, 2H), 3.43 (t, 2H).

Intermediate 18: (4-{[Methyl(3,5-dimethylisoxazole-4-carbonyl)-amino]-methyl}-thiazol-2-yl) carbamic acid phenyl ester

Step 1: The crude tert-butyl 4-((methylamino)methyl)thiazol-2-ylcarbamate (Intermediate 17, 7.78 g, 32 mmol) was dissolved in DCM (100 mL) and DIPEA (6.34 mL, 38 mmol, 1.2 eq.) was added. This mixture was stirred for 5 minutes and 3,5-dimethylisoxazole-4-carbonylchloride (5.45 mL, 0.035 mmol, 1.1 eq.) was added and the reaction mixture was stirred at ambient temperature overnight. After work-up and purification by column chromatography (silica gel, 3% MeOH/DCM) the tert-butyl 4-((N,3,5-trimethylisoxazole-4-carboxamido)methyl) thiazol-2-ylcarbamate was furnished (6.7 g, ca. 80% purity). ¹H NMR (DMSO-d₆): 11.79 (s, br, 1H), 7.50 (s, 1H), 7.36 (d, 1H), 7.10 (m, 2H), 5.14 (s, br, 1H), 4.63 (s, 2H), 4.36 (s, 2H), 3.83 (t, 2H), 3.43 (t, 2H).

Step 2: The crude tert-butyl 4-((N,3,5-trimethylisoxazole-4-carboxamido)methyl) thiazol-2-ylcarbamate (6.7 g) was dissolved in an excess of 4M HCl in dioxane (300 mL). The reaction was stirred at 40 C for 2 hours. Volatiles were removed under reduced pressure and 6.16 g of N-((2-aminothiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide hydrochloride was obtained. ¹H-NMR (DMSO-d₆): δ 11.79 (s, br, 1H), 7.50 (s, 1H), 7.36 (d, 1H), 7.10 (m, 2H), 5.14 (s, br, 1H), 4.63 (s, 2H), 4.36 (s, 2H), 3.83 (t, 2H), 3.43 (t, 2H).

Step 3: N-((2-aminothiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide hydrochloride (6.16 g, 20.34 mmol) was dissolved in pyridine (35 mL) and DMAP (150 mg, 5 mol %) was added. The solution was cooled to 0° C. and a solution of phenylchloroformate (2.55 mL, 3.18 g, 20.34 mmol) in tetrahydrofuran (35 mL) was added dropwise. The mixture was stirred overnight at room temperature and the volatiles were evaporated in vacuo. The residue was taken up in water/EtOAc. The organic phase was dried over MgSO₄ and the volatiles were evaporated under reduced pressure. The material was crystallized from EtOAc/i-Pr₂O to afford (4-{[methyl(3,5-dimethylisoxazole-4-carbonyl)-amino]-methyl}-thiazol-2-yl) carbamic acid phenyl ester (1.80 g) as a tan-colored solid (purity ˜85%). ¹H NMR (CDCl₃): δ 9.85 (bs, 1H), 7.45 (m, 2H), 7.25 (m, 2H), 7.20 (m, 2H), 6.80 (b, 1H), 4.75 (bs, 1H), 4.45 (bs, 1H), 3.00 (bs, 3H), 2.36 (s, 3H), 2.24 (s, 3H).

Intermediate 19: 1-(3-Fluorobenzyl)-3-(4-((2-hydroxyethylamino)methyl)thiazol-2-yl)urea

1-(3-Fluorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea (Intermediate 7) was taken up in tetrahydrofuran and an excess of the 2-amino-ethanol (20 equiv.) was added. The reaction was allowed to stir overnight at room temperature. The reaction was poured into water and extracted with EtOAc, partitioned with brine, dried over Na₂SO₄, filtered, and volatiles were removed in vacuo. The resulting solid was triturated with EtOAc, followed by diethyl ether to give the title compound.

Intermediate 20: 1-(3,5-Difluorobenzyl)-3-(4-((methylamino)methyl)thiazol-2-yl)urea

Step 1: A 3-neck 500 ml round bottle flask was charged with 4-Chloromethyl-thiazol-2-ylamine hydrochloride (Intermediate 1, 1 eq.) and CDI (1.05 eq.) and purged with nitrogen. Anhydrous THF was added via cannula. To the resulting stirring granular suspension was added DIPEA (1.05 eq.) dropwise via an addition funnel. After the addition of DIPEA was complete, the 3,5-difluoro-benzyl amine (1.0 eq.) was added dropwise in the same manner. The reaction was quenched with DI water and the THF was removed in vacuo. The resulting orange residue was partitioned with water and DCM. The organic layer was dried with Na₂SO₄, filtered and solvent was removed in vacuo. The crude was purified by column chromatography (acetone/hexanes) followed by recrystallization from iPrOAc and hexanes. The solid was isolated via filtration and dried under vacuum to give 1-(4-Chloromethyl-thiazol-2-yl)-3-(3,5-difluoro-benzyl)-urea.

Step 2: The title compound was prepared from the above 1-(4-Chloromethyl-thiazol-2-yl)-3-(3,5-difluoro-benzyl)-urea following the procedure described for Intermediate 3.

Intermediate 21: 1-(4-(Chloromethyl)thiazol-2-yl)-1-(2,4-dimethoxybenzyl)-3-(3-fluorobenzyl)urea

Step 1: The HCl salt of 4-(chloromethyl)thiazol-2-amine (10 mmol) was suspended in DCM (50 ml), and 2,4-dimethoxybenzaldehyde (1.0 eq. of) and DIEA (1.0 eq.) were added. To the mixture, acetic acid (1 ml) was added followed by addition of sodium triacetoxyborohydride (2.5 eq.) and the reaction was stirred at room temperature overnight. The reaction mixture was filtered through Celite and washed with DCM. The filtrate was concentrated and purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM to give 4-(chloromethyl)-N-(2,4-dimethoxybenzyl)thiazol-2-amine.

Step 2: The 4-(chloromethyl)-N-(2,4-dimethoxybenzyl)thiazol-2-amine was dissolved in DCM (50 ml) and 3-fluorobenzylisocyanate (1.2 eq.) was added and stirred overnight. The mixture was concentrated and the residue was purified on a column using 0-100% gradient of EtOAc and hexanes to give the title compound.

Intermediate 22: (4-{[Methyl-(3-methyl-pyrazine-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-carbamic acid phenyl ester

Step 1: To a solution of tert-butyl 4-((methylamino)methyl)thiazol-2-ylcarbamate (Intermediate 17, 1.30 g, 5.3 mmol) and 3-methylpyrazine-2-carboxylic acid (1.1 g, 8 mmol) in CH2Cl2 (25 mL) was added DCC (1.64 g, 8 mmol). The mixture was stirred for 2 hours and the solids were removed by filtration. The filtrate was concentrated in vacuo and purified by column chromatography (2% MeOH in CH2Cl2, Rf=0.15) to afford tert-butyl 4-((N,2-dimethylpyrazine-3-carboxamido)methyl)thiazol-2-ylcarbamate (1.30 g, 3.6 mmol) as an off-white solid in 68% yield.

Step 2: A solution of tert-butyl 4-((N,2-dimethylpyrazine-3-carboxamido)methyl)thiazol-2-ylcarbamate (1.30 g, 3.6 mmol) in dioxane (10 mL) was treated with 4N HCl in dioxane (10 mL) for 2 hours. The resulting suspension was concentrated in vacuo to afford N-((2-aminothiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide (1.10 g).

Step 3: A mixture of N-((2-aminothiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide (555 mg, 1.84 mmol) and DMAP (20 mg) in pyridine (10 mL) was cooled to 0° C. and a solution of phenyl chloroformate (433 mg, 2.8 mmol) in THF was added drop wise. The mixture was stirred overnight and all volatiles were removed in vacuo at 30° C. The residue was triturated with TBME to afford (4-{[Methyl-(3-methyl-pyrazine-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-carbamic acid phenyl ester (125 mg) as a tan colored solid (purity 96%).

Intermediate 23: 3-((2-(3-(3,4-Dichlorobenzyl)ureido)thiazol-4-yl)methylamino) propylphosphonic acid

Step 1: 0.58 g of 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid was dissolved in 15 ml of DMF and 3.0 eq. of DIEA and 1.05 eq. of TBTU was added. To the mixture, 1.2 eq. of N,O-dimethylhydroxylamine HCl salt was added and the reaction was stirred at room temp. overnight. The product was precipitated from water, filtered, washed with water and dried to give 2-(3-(3,4-dichlorobenzyl)ureido)-N-methoxy-N-methylthiazole-4-carboxamide.

Step 2: 1.0 g of 2-(3-(3,4-dichlorobenzyl)ureido)-N-methoxy-N-methylthiazole-4-carboxamide was dissolved in 20 ml dry tetrahydrofuran and cooled to −78 C. 1.10 eq. of 1 N lithium aluminum hydride in tetrahydrofuran was added slowly. The reaction was stirred at 0 C for 2 hours. The reaction was cooled to −78 C again and quenched with 1 N HCl and extracted with EtOAc three times. The organic was combined, dried over sodium sulfate and concentrated. The residue was purified by column chromatography using 0-100% gradient of EtOAc and hexanes to give 1-(3,4-dichlorobenzyl)-3-(4-formylthiazol-2-yl)urea.

Step 3: 300 mg of 1-(3,4-dichlorobenzyl)-3-(4-formylthiazol-2-yl) urea was dissolved in 5 ml MeOH. 1.0 eq. of tetrabutylammonium bromide and 1.0 eq. of sodium hydroxide were added followed by addition of 1.0 eq. of 3-aminopropylphosphonic acid. To the mixture, 3.0 eq. of sodium cyanoborohydride was added and the reaction was stirred at room temp. overnight. The reaction mixture was loaded to reverse phase column and purified by HPLC to give 3-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methylamino)propylphosphonic acid.

Intermediate 24: 1-(4-(1-Amino-2-hydroxyethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea

Step 1: An N-methylpyrrolidinone (5 mL) solution of ethyl 2-(2-aminothiazol-4-yl)-2-oxoacetate (commercial, 1.00 g, 5.0 mmol) and 1-fluoro-3-(isocyanatomethyl)benzene (831 mg, 5.5 mmol) was heated in a microwave reactor at 120 C for 30 minutes. Upon cooling, water (50 mL) was added with vigorous stiffing. Filtration of the precipitate afforded ethyl 2-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)-2-oxoacetate. M/Z 352 (M+H)⁺. The filtrate was dissolved in EtOH (100 mL) then hydroxylamine hydrochloride (700 mg, 10 mmol) and sodium acetate (1.07 g, 13 mmol) were added to the mix. The solution was stirred at 75 C for 4 hours and filtered while hot. Evaporation of the mixture and Flash chromatography afforded ethyl 2-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)-2-(hydroxyimino)acetate as a mixture of isomers. M/Z 367 (M+H)⁺.

Step 2: LiAlH₄ (10 mL, 10 mmol, 1 M in THF) was added to a THF (20 mL) solution of ethyl 2-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)-2-(hydroxyimino)acetate (1.05 g, 2.86 mmol). The mixture was stirred for a day at 50 C. Upon cooling the mixture to 0 C, Na₂SO₄x10H₂O (9.2 g, 28.6 mmol) was added carefully. The suspension was stirred for two days at ambient temperature which was followed by the addition of NaHSO₄ (1.2 g, 28.6 mmol) and MeOH (20 mL). The mixture is further stirred for an hour then HCl (5 mL, 2 M in ether) was added. Stirring was continued for another hour. Filtration, evaporation of the filtrate and Flash chromatography afforded 1-(4-(1-amino-2-hydroxyethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea. ¹H NMR (400 MHz, MeOH): δ 7.28 (m, 1H), 7.09 (d, 1H), 7.01 (d, 1H), 6.92 (td, 1H), 6.81 (s, 1H), 4.42 (s, 2H), 4.10 (m, 1H), 3.84 (dd, 1H), 3.72 (dd, 1H). MS (ES+): M/Z 311 (M+H)⁺.

Intermediate 25: 1-(3-Fluorobenzyl)-3-(5-isopropyl-4-((methylamino)methyl)thiazol-2-yl)urea

Step 1: A THF (5 mL) solution of methy; 2-amino-5-isopropylthiazole-4-carboxylate (commercially available, 200 mg, 1 mmol) and 1-fluoro-3-(isocyanatomethyl)benzene (140 μL, 1.1 mmol) was microwave irradiated at 160 C for 35 minutes. Usual work-up concluded with recrystallization from MeOH afforded methyl 2-(3-(3-fluorobenzyl)ureido)-5-isopropylthiazole-4-carboxylate. ¹H NMR (400 MHz, DMSO-d6): δ7.35 (m, 1H), 7.08 (m, 3H), 4.34 (d, 2H), 3.94 (m, 1H), 3.76 (s, 3H), 1.24 (d, 6H). MS (ES+): M/Z 452 (M+H)⁺.

Step 2: LiAlH₄ (5.5 mL, 5.5 mmol, 1 M in THF) was added to a THF (30 mL) solution of methyl 2-(3-(3-fluorobenzyl)ureido)-5-isopropylthiazole-4-carboxylate (780 mg, 2.22 mmol) at 0 C. Upon completion of the reaction Na₂SO₄x10H₂O (1.5 g, 4.5 mmol) was added carefully. The suspension was stirred for a day at ambient temperature which was followed by the addition of NaHSO₄ (0.5 g, 4.5 mmol) and MeOH (5 mL). The mixture extracted with CH₂Cl₂, washed with dilute HCl, dried and evaporated to afford 1-(3-fluorobenzyl)-3-(4-(hydroxymethyl)-5-isopropylthiazol-2-yl)urea. ¹H NMR (400 MHz, CDCl₃): δ 7.70 (s, 1H, br), 7.24 (m, 1H), 7.05 (d, 1H), 6.99 (d, 1H), 6.92 (td, 1H), 4.55 (s, 2H), 4.41 (d, 2H), 3.20 (m, 1H), 1.27 (d, 6H). MS (ES+): M/Z 324 (M+H)⁺.

Step 3: 1-(3-Fluorobenzyl)-3-(4-(hydroxymethyl)-5-isopropylthiazol-2-yl)urea (32 mg, 0.1 mmol) was oxidized with MnO₂ (87 mg, 1.0 mmol) in CH₂Cl₂ (5 mL). Filtration and evaporation afforded 1-(3-fluorobenzyl)-3-(4-formyl-5-isopropylthiazol-2-yl)urea. ¹H NMR (400 MHz, CDCl₃): δ 9.83 (s, 1H), 7.60 (s, 1H, br), 7.27 (m, 1H), 7.12 (d, 1H), 7.06 (d, 1H), 6.93 (td, 1H), 4.48 (d, 2H), 3.80 (m, 1H), 1.42 (d, 6H). MS (ES+): M/Z 322 (M+H)⁺.

Step 4: NaBH₄ (100 mg, 3 mmol) was added in portions to a mixture of MeNH₂ (5 mL, 30% in EtOH) and 1-(3-fluorobenzyl)-3-(4-formyl-5-isopropylthiazol-2-yl)urea (322 mg, 1 mmol) at 0 C. The mixture was stirred for 6 hours then quenched with dilute HCl solution. Basic aqueous work-up with CH₂Cl₂ followed by flash chromatography afforded 1-(3-fluorobenzyl)-3-(5-isopropyl-4-((methylamino)methyl)thiazol-2-yl)urea. MS (ES+): M/Z 337 (M+H)⁺.

Intermediate 26: 1-(4-((2,2-Difluoroethylamino)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea

1-(4-Iodomethyl-thiazol-2-yl)-3-(3-fluorobenzyl)-urea (Intermediate 7, 1 eq.) was taken up in THF (0.3 M) and 2,2-difluoroethanamine (20 eq.) was added. The reaction was stirred overnight at ambient temperature. Some of the starting material, Intermediate 7 remained. Added additional 2,2-difluoroethanamine (10 equivalents). The reaction was complete after 2-4 hours. Removed solvent; coevaporated twice with MeOH. Crude is a 1:1 mixture of title compound and bis addition impurity. (used as is in subsequent step).

Intermediate 27: Not used Intermediate 28: N-(4-((methoxy(methyl)amino)methyl)thiazol-2-yl)-1H-imidazole-1-carboxamide

Step 1: 2-Amino-4-(N-methoxy-N-methyl-aminomethyl)thiazole. A mixture of 2-amino-4-chloromethyl-thiazole hydrochloride (27.8 g, 0.15 mol), N,O-dimethylhydroxylamine hydrochloride (87.8 g, 0.90 mol), and anhydrous THF (300 mL) was rapidly stirred and DIPEA (157 mL, 0.90 mol) was added. The resulting mixture was heated at 60 C for 10-15 hours. The mixture was cooled in an ice/salt bath and the solid byproduct (DIPEA hydrochloride) was removed by filtration and washed with cold THF (300 mL). The combined filtrate was concentrated to afford the title compound as a dark oil (31 g, >100% theory), which partially crystallized on standing. This product was used in the next step without further purification.

Step 2: 2-(N-Imidazocarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)thiazole. A flask was purged with dry nitrogen and charged with carbonyl diimidazole (37.2 g, 0.222 mol) and anhydrous THF (0.4 L). The mixture was stirred and heated to 27-32 C, affording a clear solution. A solution of crude 2-amino-4-(N-methoxy-N-methyl-aminomethyl)thiazole (31 g (as is), ˜0.15 mol) in anhydrous THF (0.1 L) was added dropwise. The resulting cloudy reaction mixture was cooled to room temperature and stirred overnight affording a thick slurry. The solids were isolated by filtration, washed with diethyl ether (80 mL), and dried in vacuo (no heat) to afford the title compound as an off-white solid (20.0 g, 0.075 mol, 50% yield for 2-steps).

Intermediate 29: 1-[(5-Chlorothiophen-2-yl)methyl)-3-(4-((methylamino)methyl) thiazol-2-yl]urea

Step 1: Intermediate 28 (imidazolide) was reacted with C-(5-chlorothiophen-2-yl)methylamine using Method 7.

Step 2: The methoxyamine-urea product obtained in Step 1 was reduced with micronized zinc dust in acetic acid, following the procedure for Intermediate 5/Alternative Process/Step 2, to afford Intermediate 29.

Intermediate 30: 1-((5-Chlorothiophen-3-yl)methyl)-3-(4-((methylamino)methyl) thiazol-2-yl) urea

Step 1: Intermediate 28 (imidazolide) was reacted with Intermediate 37 (amine) using Method 7.

Step 2: The methoxyamine-urea product obtained in Step 1 was reduced with micronized zinc dust in acetic acid, following the procedure for Intermediate 5/Alternative Process/Step 2, to afford intermediate 30.

Intermediate 31: 5-(Methoxymethyl)-3-methylisoxazole-4-carboxylic acid

Step 1: A mixture of methyl 4-methoxyacetoacetate (34.2 mmol, 5 g) and pyrrolidine (1.1 eq, 37.6 mmol, 2.6 g) in toluene (50 ml) was refluxed under Dean-Stark-conditions for 14 h. The solvent was then removed under reduced pressure. The remaining oil was dissolved in chloroform (50 ml) and nitroethane (3 eq, 102.6 mmol, 7.69 g) and triethylamine (1.1 eq, 37.6 mmol, 3.79 g) were added. The mixture was cooled to 0° C. before dropwise addition of a solution of phosphorus oxychloride (1.1 eq, 37.6 mmol, 5.75 g) in chloroform (20 ml). The mixture was stirred over night at room temperature and then poured into water (20 ml). The organic layer was washed successively with hydrochloric acid (20 ml), aqueous sodium hydroxide (5% w/v, 50 mL) and brine (50 mL), dried (Na₂SO₄) and concentrated. After column chromatography, 1.47 g of methyl 5-(methoxymethyl)-3-methylisoxazole-4-carboxylyate was isolated. ¹H NMR (300 MHz, CDCl₃), δ 4.80 (s, 2H), 3.87 (s, 3H), 3.45 (s, 3H), 2.45 (s, 3H).

Step 2: The methyl ester obtained in Step 1 (7.8 mmol, 1.4 g) was dissolved in tetrahydrofuran/water (20 ml, 10:1). Lithium hydroxide (1.1 eq, 8.68 mmol, 0.21 g) was added and the mixture was stirred at room temperature over night. The solvent was removed under reduced pressure to give the title compound as a white solid (0.85 g, 60% yield). ¹H NMR (300 MHz, CD₃OD): δ 4.83 (s, 2H), 3.41 (s, 3H), 2.42 (s, 3H).

Intermediate 32: 5-Methylpyridazine-4-carboxylic acid

Intermediate 33: 4-Methylpyridazine-3-carboxylic acid

Step: 1: Ethyl pyruvate (4.5 eq, 66.9 g) was cooled to −10° C. and H₂O₂ (3.0 eq, 37.3 g) was added drop wise keeping the temperature below 0° C. Subsequently, the mixture was stirred for 15 minutes. A solution of 4-methylpyridazine (12.05 g, 128 mmol), FeSO₄7H₂O (3.0 eq, 106.8 g), H₂SO₄ (36 g) in H₂O (35 mL)/CH₂Cl₂ (270 mL) was cooled to −5° C. The mixture of H₂O₂ and ethyl pyruvate was added drop wise keeping the temperature below 0° C. and stirred for 15 minutes. The reaction mixture was poured into H₂O/EtOAc mixture and stirred for 3 hours. The H₂O-layer was removed and the organic layer was stirred overnight with aq. Na₂SO₃. Subsequently, the layers were separated and the organic layer was washed twice with H₂O and dried over MgSO₄. Removal of the volatiles afforded a mixture of ethyl 5-methylpyridazine-4-carboxylate and ethyl 4-methylpyridazine-3-carboxylate and 3 other compounds (29.0 g) as a yellow/orange oil.

The crude material was purified by silica chromatography, affording a mixture of ethyl 5-methylpyridazine-4-carboxylate and ethyl 4-methylpyridazine-3-carboxylate and another compound (3.7 g) as a yellow oil. The mixture was again purified by column chromatography (SiO₂; CH₂Cl₂/EtOAc 9:1-8:2) affording Ethyl 5-methylpyridazine-4-carboxylate (614 mg, 29% yield) as a yellow oil and Ethyl 4-methylpyridazine-3-carboxylate (447 mg, 23% yield) as a yellow oil/solid.

Intermediate 32: To a solution of ethyl 5-methylpyridazine-4-carboxylate (240 mg, 1.4 mmol) in H₂O/THF was added 7.5 N aq. NaOH (1.25 eq, 0.25 mL) and the mixture was stirred for 1 hour at 60° C. Concentrated HCl was added to pH 2 and subsequently the volatiles were removed in vacuo. The residue was first stirred with EtOAc and the solids were collected by filtration. Then stirred with THF and the solids were again collected by filtration. The solids were extracted with MeOH and removal of the volatiles afforded 5-methylpyridazine-4-carboxylic acid (358 mg) as a brown solid.

Intermediate 33: To a solution of ethyl 4-methylpyridazine-3-carboxylate (240 mg, 1.4 mmol) in H₂O/THF was added 7.5 N aq. NaOH (1.25 eq, 0.25 mL) and the mixture was stirred for 1 hour at 60° C. Concentrated HCl was added to pH 2 and subsequently the volatiles were removed in vacuo. The residue was first stirred with EtOAc and the solids were collected by filtration then stirred with THF and the solids were again collected by filtration. The solids were extracted with MeOH and removal of the volatiles afforded 4-methylpyridazine-3-carboxylic acid (328 mg) as a brown solid.

Intermediate 34: 3-Methyl-pyrazine-2-carboxylic acid

A solution of dimethylpyrazine (25 g, 231 mmol) in water (250 mL) was heated at 70° C. and a solution of KMnO₄ (82.2 g, 520 mmol) in water was added at such a rate to maintain the temperature between 70 and 75° C. The mixture was stirred until the purple color vanished and was filtered over Celite. The aqueous solution was extracted with EtOAc (6×800 mL), dried over Na₂SO₄ and concentrated in vacuo. The residue was titrated with TBME to afford 3-methylpyrazine-2-carboxylic acid (9.3 g, 67 mmol) as a white solid in 30% yield.

Intermediate 35: 3-(Ethoxycarbonyl)-5-methylisoxazole-4-carboxylic acid

Step 1: To a solution of tert-butyl acetoacetate (42.1 mmol, 6.6 g) and ethyl cyanoformate (1.2 eq, 50.5 mmol, 5.0 g) in dry DCM (20 ml) [Zn(acac)₂] (2.1 mmol, 0.55 g) was added. After stirring at room temperature for 2 hours, TLC indicated complete conversion. The solvent was evaporated under reduced pressure, the residue was dissolved in ethyl ether and the suspension was filtered through Celite. After concentration, 2-acetyl-3-oxo-succinic acid 1-tert-butyl ester 4-ethyl ester (8.93 g, 82% yield) was obtained as a yellow oil.

Step 2: The 1,3-diketone obtained in Step 1 (34.7 mmol, 8.9 g) was dissolved in chloroform (50 ml). 4.91 g of triethylamine (1.4 eq, 48.6 mmol) and hydroxylamine-HCl salt (1.3 eq, 45.1 mmol, 3.13 g) were added and the mixture was refluxed for 3 h. The reaction was cooled to room temperature and 1N aq. HCl (100 ml) was added followed by extraction with DCM (3×100 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated. Column purification by silica gel yielded (6.89 g, 77% yield) of tert-butyl 3-(ethoxycarbonyl)-5-methylisoxazole-4-carboxylate. ¹H NMR (300 MHz, CDCl₃), δ 4.42 (q, 2H), 2.66 (s, 3H), 1.53 (s, 15H), 1.39 (t, 3H).

Step 3: The tert-butyl ester obtained in Step 2 (0.8 g, 3.13 mmol) was dissolved in formic acid (20 mL) and stirred at room temperature overnight. 6N aq. HCl (50 ml) was added. The mixture was extracted with DCM (3×50 mL). The combined organic layers were dried over sodium sulfate and concentrated to give the title compound, Intermediate 35: 3-(ethoxycarbonyl)-5-methylisoxazole-4-carboxylic acid, as a brownish oil (0.4 g, 64%). ¹H NMR (300 MHz, MeOH-d₄): δ 4.40 (q, 2H), 2.68 (s, 3H), 1.35 (t, 3H).

Intermediate 36: C-(5-Fluoro-thiophen-2-yl)-methylamine

Step 1: Synthesis of 5-fluoro-thiophene-2-carbonitrile starting from 5-nitro-thiophene-2-carbonitrile following a literature procedure: Syn Comm 30 (19) 3629-3632 (2000).

Step 2: A 500 ml 3 neck flask was fitted with septum, N₂ inlet, and an addition funnel. Under N₂, the flask was charged with LAH (130 ml of a 1M solution of LAH in diethyl ether), and cooled in an ice bath with stirring. Added the 5-Fluoro-thiophene-2-carbonitrile (9.43 g) as a solution in dry diethyl ether (15 mL) over 30 minutes via addition funnel. After addition, the reaction was allowed to warm to room temperature over an hour. The resulting thin mixture was diluted with diethyl ether (200 ml) and then slowly, 2N NaOH (25 ml) was added dropwise. Stirred overnight; a tan mass was present. Filtered the diethyl ether layer. The tan mass was broken up and titrated with diethyl ether (50 ml) and then filtered. The diethyl ether portions were combined and the solvent removed in vacuo. Dried overnight under reduced pressure to give a clear orange oil. Distilled at 68-70° C. (10 mm) to give C-(5-fluoro-thiophen-2-yl)-methylamine as a clear colorless liquid.

Intermediate 37: (5-Chlorothiophen-3-yl)methanamine hydrochloride

Step 1: To a solution of N-chlorosuccinimide (1.0 eq, 12.2 g) in hexane (100 mL) were added thiophene-3-carbonitrile (10 g, 91.6 mmol) and 70% HClO₄ (1 mol %, 0.1 mL). The reaction mixture was stirred overnight at room temperature and subsequently K₂CO₃ was added. Removal of the solids and the volatiles afforded the crude product as a yellow oil. (This was a mixture of starting material: desired product: wrong isomer: dichlorinated 48%:26%:19%:6%.) Purification twice by column chromatography afforded 5-chlorothiophene-3-carbonitrile (1.71 g, 13%) as a yellow oil.

Step 2: To a pre-cooled (ice-water bath) solution of BH₃.THF (3.4 eq, 11.8 mL) was added a solution of 5-chlorothiophene-3-carbonitrile (0.5 g, 3.48 mmol) in THF (11.5 ml). The reaction mixture was stirred for 4 hours at room temperature and subsequently 6 N HCl (17 ml) was added slowly followed by H₂O/MeOH (17/114 mL). The reaction mixture was stirred overnight. Removal of the volatiles afforded the title product (1.0 g) as an off-white solid.

Intermediate 38: 3-Chloromethyl-[1,2,4]thiadiazol-5-ylamine

2-Chloroacetamidine hydrochloride (10.3 g, 80 mmol) was dissolved in anhydrous MeOH (300 mL) and then cooled to 0 C. TEA (20.2 g, 200 mol) was added followed by bromine (11.5 g, 72 mmol, dropwise over 5 minutes at 0 C). Potassium thiocyanate (8.15 g, 84 mmol) in MeOH (100 mL) was added dropwise over 1 hour and the resultant mixture was stirred at 0 C for 2 hours. Reaction was maintained at ambient temperature for 1 h. Solid was removed by filtration and filtrate concentrated in vacuo. This syrupy residue was treated with EtOAc (300 mL) followed by filtration and purification by silica gel chromatography (PE:EA=4:1 to 3:1) to afford Intermediate 67: 3-chloromethyl-[1,2,4]thiadiazol-5-ylamine as white solid (5 g, 42%). ¹H-NMR (400 MHz, DMSO-d₆) δ: 8.03 (s, 2H, —NH₂), 4.51 (s, 2H, —CH₂Cl); LC-MS (m/z): 150.1 μM+Hr.

Intermediate 39: (3-{[Methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-[1,2,4]thiadiazol-5-yl)-carbamic acid phenyl ester

Step 1: 3-Chloromethyl-[1,2,4]thiadiazol-5-ylamine (Intermediate 38) (1.5 g, 10 mmol) was dissolved in 27% methylamine alcohol solution (20 mL, 174 mmol) to give a yellowish solution. The solution was heated in microwave reactor at 60 C for 15 min After cooling to room temperature, the reaction mixtures were combined and concentrated at room temperature (20-25 C; attention: the product is sensitive to heat). A solution of potassium carbonate (9.7 g, 70 mmol) in water (15 mL) was added into the residue and the resultant mixture was concentrated to dryness. The crude product was purified by silica gel column chromatography (DCM:MeOH=5:1) to afford 3-(N-methylaminomethyl)[1,2,4]thiadiazol-5-ylamine (14.0 g, yield: 69%) as a yellow solid. LC-MS (m/z): 145.1 [M+H]⁺.

Step 2: To a solution of (R)-tetrahydrofuran-2-carboxylic acid (5.0 g, 43 mmol) in DMF (100 mL) was added carbonyl diimidazole (7.68 g, 47 mmol) at 0 C under N₂. After 2 hours agitation at 0 C, the product obtained from Step 1 (7.0 g, 49 mmol) in DMF (20 mL) was added and the mixture was stirred at room temperature overnight. The reaction mixture was then diluted with water (800 mL), extracted with EA (10×200 mL). The combined organic layers were washed twice with brine (100 mL) and concentrated. The residue was purified by silica gel column chromatography (PE:EA=1:3) to afford (R)-tetrahydro-furan-2-carboxylic acid (5-amino-[1,2,4]thiadiazol-3-ylmethyl)-methyl-amide (5.9 g, yield: 59%) as a red syrup. LC-MS (m/z): 243.1 [M+H]⁺.

Step 3: To a solution of the product from Step 2, (R)-tetrahydro-furan-2-carboxylic acid (5-amino-[1,2,4]thiadiazol-3-ylmethyl)-methyl-amide (3.0 g, 12.4 mmol), and pyridine (1.08 g, 13.6 mmol) in DCM (120 mL) was added phenyl chloroformate (1.95 g, 12.4 mmol) by syringe at 0 C under N₂. The reaction mixture was stirred at room temperature overnight, concentrated and purified by silica gel column chromatography (PE:EA=1:1) to afford Intermediate 39: (3-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-[1,2,4]thiadiazol-5-yl)-carbamic acid phenyl ester (3.0 g, yield: 67%) as a pale solid. LC-MS (m/z): 363.1 [M+H]⁺.

Intermediate 40: 2-(3-(3-Fluorobenzyl)ureido)-4-(N-methyl-aminomethyl)-5-fluorothiazole

Step 1: 2-(tert-Butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)thiazole. A mixture of Intermediate 28: 2-(N-imidazocarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)thiazole (23.3 g, 87.2 mmol) and anhydrous tert-butanol (140 mL) was stirred under an inert atmosphere and heated to 80 C. After 20 minutes, a clear solution was obtained. tert-Butanol was evaporated at reduced pressure and the oily residue was dissolved in hexane (200 mL) and washed with water (2×100 mL). The organic layer was dried over sodium sulfate, filtered and evaporated to afford the title compound as a colorless oil which crystallized on standing (21.4 g, 90% yield).

Step 2: Fluorination of Thiazole 5-Position (Organic Process R & D (10), 346-348 (2006)). 2-(tert-Butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole. A solution of 2-(tert-butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)thiazole (34.4 g, 0.126 mol) and anhydrous THF (0.71 L) was cooled to −78 C under an inert atmosphere. A solution of 1.6 M n-BuLi in hexane (165 mL, 0.264 mol) was added dropwise over 45 minutes. The resulting mixture was stirred at −78 C for 2-3 hours, then treated dropwise with a solution of N-fluorobenzenesulfonimide (51.6 g, 0.164 mol) in THF (0.3 L). The reaction was warmed to −10 C and quenched with 1 N HCl (0.28 L). The mixture was made alkaline with saturated sodium bicarbonate solution (˜200 mL) and extracted with diethyl ether (0.5 L). The organic layer was dried with magnesium sulfate and concentrated to leave a red oil (51 g) which was purified by silica gel chromatography (40% EtOAc/hexane) to afford the title compound as a yellow resin (15.1 g, 41% yield).

Step 3: 2-(3-(3-fluorobenzyl)ureido)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole. A solution of 2-(tert-butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole (3.6 g, 12.4 mmol) in 1,4-dioxane (60 mL) was saturated with dry HCl gas and held overnight. The mixture was evaporated to dryness to leave the 2-amino-5-fluorothiazole dihydrochloride salt (3.3 g, 100% yield).

Step 4: The salt was suspended in anhydrous THF (50 mL) and DIPEA (4.3 mL, 25 mmol) was added. The resulting mixture was added to a solution of carbonyl diimidazole (2.07 g, 12.8 mmol) in THF (30 mL) at 30-35 C. After stirring overnight at room temperature, the solids were collected and washed with diethyl ether (5 mL) to give a 2-(N-imidazocarbonylamino)-5-fluorothiazole intermediate (2.1 g, 55% yield).

Step 5: The imidazolide intermediate (2.0 g, 6 mmol) was suspended in THF (40 mL) and 3-fluorobenzylamine (0.71 mL, 6 mmol) was added slowly. After 1 hour, water (40 mL) was added and THF was evaporated at reduced pressure. Extraction with DCM (60 mL), drying over sodium sulfate, and concentration afforded the title compound as a pale yellow foam (2.05 g, 100% yield).

Step 6: 2-(3-(3-Fluorobenzyl)ureido)-4-(N-methyl-aminomethyl)-5-fluorothiazole (Intermediate 40). A solution of 2-(3-(3-fluorobenzyl)ureido)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole (2.05 g, 6 mmol) in glacial acetic acid (30 mL) was treated with micronized zinc dust (12 g) and stirred at 60 C for 1-2 hours. The mixture was diluted with water (30 mL) and filtered on Celite. The filter cake was washed with 1:1 HOAc:water (3×20 mL) and the combined filtrate were brought to pH 10 with ammonium hydroxide (−82 mL). The resulting mixture was stirred in ice and the crude product was collected by filtration and washed with water (4 mL). The crude product was further purified by silica gel chromatography (5:94:1 MeOH:DCM:NH₄OH) to afford Intermediate 40 as a white solid (1.25 g, 67% yield).

Intermediate 41: 1-[4-(Cyano-methylamino-methyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea

Step 1: Preparation of acetic acid 2-amino-thiazol-4-ylmethyl ester. 1-Chloro-3-hydroxy-propan-2-one (15.06 g) and thiourea (8.36 g) were dissolved in EtOH (55 mL) and heated at reflux over 30 min. The reaction mixture was concentrated under reduced pressure to afford the desired product.

Step 2: Preparation of -(3-fluoro-benzyl)-3-(4-hydroxymethyl-thiazol-2-yl)-urea. To a solution of acetic acid 2-amino-thiazol-4-ylmethyl ester (6.89 g) in THF (50 mL) were 3-fluorobenzylisocyanate (5.50 g) and TEA (5.03 mL) added. The resultant solution was heated at 70° C. over 2 h. Then, MeOH (30 mL) and NaOH (6N, 15 mL) were added to the above solution. The reaction mixture was heated at 60° C. for 30 min After cooling down, the reaction mixture was diluted with EtOAc (150 mL) and was washed with water. The organic solvents were concentrated and the residue was purified by silica-gel column chromatography to afford 8.29 g of the desired product-1-(3-fluoro-benzyl)-3-(4-hydroxymethyl-thiazol-2-yl)-urea.

Step 3: Preparation of 1-(3-fluoro-benzyl)-3-(4-formyl-thiazol-2-yl)-urea. (3-Fluoro-benzyl)-3-(4-hydroxymethyl-thiazol-2-yl)-urea (909.52 mg) was added in a solution of Dess-Martin periodinane (0.3 M, 10.8 mL) in DCM (100 mL) at 0° C. The reaction mixture was stirred at room temperature over a couple of hours until all starting materials were consumed. After concentration, the residue was recrystallized from DCM/Hexane to afford the desired product (580 mg).

Step 4: Preparation of 1-[4-(cyano-methylamino-methyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea. Trimethylsilyl cyanide (161 μL) was added to a solution of 1-(3-fluoro-benzyl)-3-(4-formyl-thiazol-2-yl)-urea (409 mg) and MeNH₂ (8 M, 0.4 mL) in (EtOH 10 mL) at 0° C. The reaction mixture was stirred at room temperature for 2 hours. The additional of 170 μL of trimethylsilyl cyanide was added to convert all starting material into the product. The product was purified by aqueous work-up and chromatography.

Intermediate 42: 1-(2-Methoxyethyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

Sodium hydride (60%, 120 mg, 3.0 mmol) was suspended in THF (2 ml) at 0 C. Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate (168 mg, 1.0 mmol) dissolved in THF (2 mL) was added drop-wise. Stirring was maintained until the evolution of hydrogen stopped. 1-Bromo-2-methoxyethane (208 mg, 1.5 mmol) was added and the reaction was heated at reflux at 70 C for 48 hours. Reaction was quenched with water at 0 C, acidified to pH=1-2 with HCl (2M) and was extracted with EtOAc. The organic layer was washed with water, NH₄Cl aq., and brine, and dried with Na₂SO₄, and concentrated. The residue was subjected to HPLC purification. White solid (67 mg, 0.34 mmol, 34%) was obtained after stripping of solvents and drying. ESI-MS m/z 199.4 (M+H).

Intermediate 43: Tetrahydro-2H-pyran-2-carboxylic acid

(Tetrahydro-2H-pyran-2-yl)methanol (0.51 g, 4.30 mmol) was dissolved in 10 mL of 1:1 ACN/water mixture, and bis-acetoxyiodobenzene [BAIB] (3.04 g, 9.46 mmol) was added to the mixture. It was then cooled to 0 C in an ice bath, and TEMPO (0.134 g, 0.86 mmol) was added under argon flow. The mixture was stirred at room temperature for 3 hours, and the reaction was quenched by addition of 2×20 mL of 1 M NaOH. Basic solution was washed 3×30 mL of EtOAc, and re-acidified with 1 M HCl to ca. pH 2. Aqueous layer was then extracted 6×30 mL of EtOAc, organic layers were combined, dried over sodium sulfate and evaporated. The title compound was isolated as an oil (0.34 g, 61%) was used in the next step without further purification. ¹H NMR (300 MHz, CDCl₃) δ4.11 (d, 1H, J=10.5 Hz), 3.98 (d, 1H, J=9.9 Hz), 3.53 (m, 1H), 2.10-1.92 (m, 3H), 1.60-1.54 (m, 3H).

Intermediate 44: (R)-5-Methoxytetrahydrofuran-2-carboxylic acid

Step 1: ((R)-5-methoxy-tetrahydro-furan-2-yl)-methanol. ((R)-5-Methoxy-tetrahydro-furan-2-ylmethoxy)-methyl-diphenylsilane (Pilli, R. A.; Riatto, V. B. Tet. Asymm. (2000)), 11, 3675) (0.80 g, 2.25 mmol) was dissolved in 35 mL of anhydrous MeOH and 5 mL of formic acid was added to the mixture. The mixture was stirred at room temperature for 30 minutes at which point TLC (9:1 hexanes:EtOAc) indicated complete conversion to the product. Volatiles were removed in vacuo and 0.83 g, 100% of the title compound was obtained as clear oil.

Step 2: (R)-5-methoxytetrahydrofuran-2-carboxylic acid. Material from Step 1 was oxidized via the same method in Step 2 of the synthesis of Intermediate 47, it was prepared as oil. ¹H NMR (300 MHz, CDCl₃) δ 5.19 (d, 0.6H, J=4.2 Hz), 5.10 (d, 0.4H, J=4.5 Hz), 4.63-4.58 (m, 1H), 3.42 (s, 1.2H), 3.34 (s, 1.8 Hz), 2.28-1.88 (m, 4H).

Intermediate 45: 1-(4-methoxybutanyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

Prepared by following the same method as the preparation of Intermediate 42, ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate (280 mg) was reacted with 1-bromo-2-methoxybutane (367 mg) to afford white solid (185 mg, 41%). ESI-MS m/z 227.4 (M+H).

Intermediate 46: 1-(3-methoxypropyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

Prepared by following the same method as the preparation of intermediate 42: ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate (280 mg) was reacted with 1-bromo-2-methoxybutane (337 mg) to afford white solid (42 mg, 0.20 mmol, 10%). ESI-MS m/z 213.2 (M+H).

Intermediate 47: (R)-5-methyltetrahydrofuran-2-carboxylic acid

Step 1: (R)-tert-butyl((5-methyltetrahydrofuran-2-yl)methoxy)diphenylsilane (Tet. Asym. (2000), 11, 3675) (0.523 g, 1.48 mmol) was dissolved in 5 mL of anhydrous THF, TBAF (1 M solution in THF, 1.48 mL) was added to the solution and it was stirred at room temperature under argon flow overnight. Volatiles were then removed in vacuo and resulting oil was used in the next step with no purification

Step 2: Crude (R)-(5-methyltetrahydrofuran-2-yl)methanol was dissolved in 6 mL of 1:1 ACN/water mixture, and bis-acetoxyiodobenzene [BAIB] (0.71 g, 2.20 mmol) was added to the mixture. It was then cooled to 0 C in an ice bath, and TEMPO (0.031 g, 0.2 mmol) was added under argon flow. The mixture was stirred at room temperature for 3 h, and the reaction was quenched by addition of 20 mL of 1 M NaOH. Basic solution was washed 3×15 mL of EtOAc, and re-acidified with 1 M HCl to ca. pH 2. Aqueous layer was then extracted 6×15 mL of EtOAc, organic layers combined, dried over sodium sulfate and evaporated. Resulting oil (0.05 g, 26%) was used in the next step with no purification. ¹H NMR (300 MHz, CDCl₃) δ 4.48-4.43 (m, 1H), 4.20-4.17 (m, 1H), 2.33-2.21 (m, 3H), 2.08-2.02 (m, 1H), 1.35 (dd, 3H, J1=6.3 Hz, J2=1.8 Hz).

Intermediate 48: 3-Methyloxetane-3-carboxylic acid

The title compound was prepared following the same method described in step 2 of the preparation of intermediate 47 from (3-methyloxetan-3-yl)methanol (0.51 g, 5 mmol). ¹H NMR (300 MHz, CDCl₃) δ 4.98 (d, 2H, J=6.0 Hz), 4.44 (d, 2H, J=6.0 Hz), 1.65 (s, 3H).

Intermediate 49: 3,6-Dichloropyridazine-4-carbonyl chloride

To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (1.16 g, 6 mmol) in toluene (20 mL) were added DMF (2 drops) and SOCl₂ (4 mL) and the mixture was heated at reflux temperature for 3 h. The volatiles were removed and the residue was stripped with toluene. The resulting brown oil (3,6-dichloropyridazine-4-carbonyl chloride) was used without purification.

Intermediate 50: 3,5-Dimethylpyridazine-4-carboxylic acid

Step 1: Ethyl 2,3-dimethylcycloprop-2-enecarboxylate. Under a nitrogen atmosphere 2-butyn (9.50 g, 176 mmol) was cooled to 0° C. and Rh₂(OAc)₄ (195 mg) was added. To the resulting suspension was added slowly over a period of 4.5 hours ethyl diazoacetate (8.02 g, 70 mmol). The mixture was stirred for 30 minutes and pentane (30 mL) was added. The solids were removed by filtration over Celite and the filtrate was concentrated in vacuo to afford ethyl 2,3-dimethylcycloprop-2-enecarboxylate (below) as a mixture with ethyl diazoacetate.

Step 2: Ethyl 1,5-dimethyl-2,3-diaza-bicyclo[3.1.0]hex-2-ene-6-carboxylate. Diazomethane was prepared from Diazald (21.5 g), KOH (6.6 g) in 2-(2-ethoxyethoxy)ethanol (35 mL). To the diazomethane solution in Et₂O was added ethyl 2,3-dimethylcycloprop-2-enecarboxylate as obtained above. The mixture was stirred at 0° C. for 14 days in the dark. A solution of acetic acid in Et₂O was added to quench off remaining diazomethane and the volatiles were removed in vacuo. Remaining starting material was removed by Kugelrohr distillation to afford ethyl 1,5-dimethyl-2,3-diaza-bicyclo[3.1.0]hex-2-ene-6-carboxylate (1.25 g, 6.9 mmol) as a yellowish oil in 10% yield over 2 steps.

Step 3: Ethyl 3,5-dimethyl-1,4-dihydropyridazine-4-carboxylate. To a solution of ethyl 1,5-dimethyl-2,3-diaza-bicyclo[3.1.0]hex-2-ene-6-carboxylate (1.25 g, 6.9 mmol) in ethanol (20 mL) was added a solution of NaOEt in ethanol (7 mL 0.2N) and the mixture was stirred for 10 min The resulting solution was partitioned between diethyl ether and water. The organic phase was isolated and the aqueous phase was extracted with diethyl ether. The combined organic phases were dried over MgSO₄ and the volatiles were removed in vacuo to afford ethyl 3,5-dimethyl-1,4-dihydropyridazine-4-carboxylate (1.0 g, 5.5 mmol, 80%) which was partially (circa 50%) oxidized to the pyridazine analog.

Step 4: Ethyl 3,5-dimethylpyridazine-4-carboxylate. To a solution of ethyl 3,5-dimethyl-1,4-dihydropyridazine-4-carboxylate (1.0 g, 5.5 mmol) as obtained above in acetone (30 mL) was added a solution of KMnO₄ (0.48 g, 3.0 mmol) in water (6 mL). The mixture was stirred for 30 minutes at room temperature and the solids were removed by filtration. The filtrate was concentrated and purified by column chromatography (SiO₂, EtOAc/Heptane 1/1) to afford ethyl 3,5-dimethylpyridazine-4-carboxylate (600 mg, 3.3 mmol) as a colorless oil in 60% yield.

Step 5: 3,5-Dimethylpyridazine-4-carboxylic acid (Intermediate 50). To a solution of ethyl 3,5-dimethylpyridazine-4-carboxylate (600 mg, 3.3 mmol) in ethanol (1 mL) was added a solution of NaOH (166 mg, 4.16 mmol) in water (5 mL). The mixture was heated at 50° C. for 1 hour and a clear solution was obtained. The solution was acidified by addition of aq. HCl until pH 5 and all volatiles were removed in vacuo. The residue was extracted with DCM/MeOH 4/1. The extract was concentrated to dryness to afford Intermediate 50: 3,5-dimethylpyridazine-4-carboxylic acid (550 mg) as an off-white solid.

Intermediate 51: 1-(5-Fluoro-thiophen-2-ylmethyl)-3-(4-methylaminomethyl-thiazol-2-yl)-urea

It was prepared following the same method of the preparation of Intermediate 29, starting from (5-fluoro-thiophen-2-yl)-methylamine.

Intermediate 52: Imidazole-1-carboxylic acid (4-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-amide

Step 1: tert-Butyl 4-((methylamino)methyl)thiazol-2-ylcarbamate (Intermediate 17) was coupled with (R)-2-tetrahydrofuroic acid using TBTU (Method 2) to afford (4-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-carbamic acid tert-butyl ester.

Step 2: The product from Step 1 was treated with TFA to cleave the BOC group (Method 1) to afford (R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide.

Step 3: (R)-Tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide (1.65 g, 6.5 mmol) was dissolved in THF (5 mL) and added dropwise to a solution of carbonyl diimidazole (1.1. eq) in THF (10 mL) at 35° C. After stirring overnight at 20° C., the mixture was cooled in ice. The solids were collected by filtration and washed with Et₂O to afford Intermediate 52: Imidazole-1-carboxylic acid (4-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-amide (1.2 g, 55% yield) as felty white crystals.

Intermediate 53: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carboxylic acid

Prepared from the corresponding 2-nitrile via a 3 step procedure:

Step 1: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carbonitrile was treated with sodium methoxide in MeOH to afford (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carboxylic acid methyl ester.

Step 2: The methyl ester obtained in Step 1 was reduced with LAH in THF to afford the alcohol: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-methanol.

Step 3: The alcohol obtained in Step 2 was oxidized with BAIB/TEMPO (using the procedure for Intermediate 55) to afford Intermediate 53: (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carboxylic acid.

Intermediate 54: cis-3-Methyl-tetrahydrofuran-2-carboxylic acid

Prepared by catalytic hydrogenation (Rh/C, 50 psi, MeOH) of 3-methyl-2-furoic acid.

Intermediate 55: 3-Ethyloxetane-3-carboxylic acid

(3-Ethyloxetan-3-yl)methanol (0.58 g, 5.00 mmol) was dissolved in 10 mL of a 1:1 ACN-water mixture, and bis-acetoxyiodobenzene (BAIB, 3.54 g, 11.0 mmol) was added. The mixture was cooled in an ice bath, and TEMPO (0.156 g, 1.00 mmol) was added under argon flow. The mixture was stirred at room temperature for 1 hr, and then treated with 1 M aqueous sodium hydroxide (20 mL). The solution was washed twice with EtOAc and then acidified to pH 2. The aqueous solution was extract six times with EtOAc and these combined extracts were dried over sodium sulfate and concentrated to afford 0.37 g (57%) of Intermediate 55 as oil, which was used without further purification.

Intermediate 56: cis-3-methoxy-tetrahydrofuran-2-carboxylic acid

Step 1: cis-2-Benzyloxymethyl-tetrahydro-furan-3-ol was O-methylated using methyliodide and sodium hydride in DMF.

Step 2: The 3-methoxy-compound obtained in Step 1 was hydrogenated over palladium on carbon in acetic acid to cleave the O-benzyl protecting group.

Step 3: The 2-hydroxymethyl group in the product form Step 2 was oxidized to the carboxylic acid using BAIB/TEMPO to afford Intermediate 56, which was purified by chromatography.

Intermediate 57: Benzooxazol-6-yl-methylamine [RN 872047-63-7]

Step 1: 6-Methyl-benzooxazole. A 50 ml flask was charged with 6-amino-m-cresol (2 g, 16.24 mmole), 20 ml toluene and 5.4 ml triethyl orthoformate. The reaction mixture was refluxed for 2 hours. The mixture was concentrated down to about 2.3 g crude. Purification by silicagel column chromatography using 20% EtOAc/hexane provided 1.45 g brown oil (69% yield) that solidified in the freezer.

Step 2: 6-Bromo-methyl-benzooxazole. To a 100 ml flask equipped with magnetic stirre and condenser were added: 6-methyl-benzooxazole (1.4 g, 10.52 mmole), 50 ml carbon tertrachloride, NBS (1.7 g, 9.5 mmole) and AIBN (200 mg, 1.21 mmole). The reaction mixture was refluxed for 4 hours. The mixture was cooled down, concentrated and purified by silicagel column chromatography using 10 to 15% EtOAc/hexane. 1.81 g (75% yield) yellow solid was obtained.

Step 3: 6-Azidomethyl-benzooxazole. A 100 ml flask was loaded with 6-bromo-methyl-benzooxazole (1.8 g, 8.5 mmole), 40 ml DMF and sodium azide (1.1 g, 16.98 mmole). The reaction mixture was stirred at room temperature, overnight. The reaction mixture was diluted with 40 ml water and extracted 2×50 ml EtOAc. Combined organic layers were washed with water, brine, dried over sodium sulfate, filtered and concentrated to afford 2 g oily crude. HNMR shows 90% pure product. This was used for next step.

Step 4: Benzooxazol-6-yl-methylamine (Int. 57). To a solution of 6-azidomethyl-benzooxazole (500 mg, 2.87 mmole) in 25 ml MeOH, 10% Pd/C (300 mg, 10% eq.) was added. The reaction mixture was stirred at ambient temperature under hydrogen atmosphere for 24 hours. The reaction mixture was filtered trough a pad of celite and washed with MeOH. The filtrate was concentrated to give Intermediate 57 as a brown oil (400 mg).

Intermediate 58: Acetic acid (R)-5-{2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-yl}-pyrrolidin-3-yl ester Hydrochloride

Step 1: (R)-4-Acetoxy-pyrrolidin-2-yl chloromethyl ketone was condensed with thiourea in ethanol in the manner described for Intermediate 1, to afford (R)-4-Acetoxy-2-(2-amino-thiazol-4-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester.

Step 2: (R)-4-Acetoxy-2-(2-amino-thiazol-4-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (327 mg, 1 mmol) was combined with 3,4-dichlorobenzyl isocyanate (303 mg, 1.5 mmol) in DCM (10 mL) and stirred overnight. The reaction mixture was concentrated and purified by chromatography (silica gel, DCM/MeOH/NH₄OH) to afford (R)-4-acetoxy-2-{2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester.

Step 3: The product obtained in Step 2 was dissolved in 4M HCl in 1,4-dioxane (7 mL). After stirring overnight the reaction mixture was concentrated and the residue was crystallized from THF/Et₂O to afford Intermediate 58: acetic acid (R)-5-{2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-yl}-pyrrolidin-3-yl ester hydrochloride, as a white solid (224 mg, 52% yield).

Intermediate 59: 1-{4-[(2-Amino-ethylamino)-methyl]-thiazol-2-yl}-3-(3-fluoro-benzyl)-urea bis-Trifluoroacetate

Step 1: Sodium triacetoxyborohydride (937 mg, 4.42 mmol) was added to a CH₂Cl₂ (50 mL) solution of 1-(3-fluorobenzyl)-3-(4-formylthiazol-2-yl)urea (620 mg, 2.21 mmol) and tert-butyl 2-aminoethylcarbamate (532 mg, 3.32 mmol) at 0 C. Upon completion of the reaction, it was quenched with dilute NaHCO₃. The organics were dried and evaporated. Flash chromatography afforded tert-butyl 2-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methylamino)ethylcarbamate. ¹H NMR (400 MHz, CDCl₃): δ 8.05 (1H, br), 7.28 (m, 1H), 7.00 (m, 3H), 6.61 (s, 1H), 4.80 (s, 1H), 4.49 (d, 2H), 3.73 (s, 2H), 3.17 (m, 2H), 2.63 (t, 2H), 1.41 (s, 9H). MS (ES+): M/Z 424 (M+H)⁺.

Step 2: [Method 1]: Trifluoroacetic acid (1 mL) was added to a CH₂Cl₂ (5 mL) solution of tert-butyl 2-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methylamino)ethylcarbamate (70 mg, 0.16 mmol). Upon completion of the reaction, the mixture was evaporated to dryness to afford Intermediate 59: 1-{4-[(2-amino-ethylamino)-methyl]-thiazol-2-yl}-3-(3-fluoro-benzyl)-urea bis-trifluoroacetate as a white solid.

Intermediate 60: 1-(3-Fluorobenzyl)-3-(4-(pyrrolidin-2-yl)thiazol-2-yl)urea Hydrochloride

Step 1: An ethanol (20 mL) solution of tert-butyl 2-(2-chloroacetyl)pyrrolidine-1-carboxylate (1.08 g, 4.4 mol) and thiourea (334 mg, 4.4 mmol) was stirred at 55 C for 70 hours. Upon completion of the condensation, the solution was evaporated. The solid was dissolved in CH₂Cl₂ (100 mL). It was washed with dilute NaHCO₃ solution, dried and evaporated. Recrystallization from CH₂Cl₂/hexane afforded tert-butyl 2-(2-aminothiazol-4-yl)pyrrolidine-1-carboxylate. ¹H NMR (400 MHz, CDCl₃): mixture of rotamers: δ 8.81 (s, 2H, br), 6.22 and 6.15 (2s, 1H), 4.84 and 4.78 (2s, 1H), 3.62 and 3.44 (2m, 2H), 2.4-1.8 (m, 4H), 1.46 and 1.36 (2s, 9H). MS (ES+): M/Z 270 (M+H)⁺, 170 (M−C₅H₈O₂)⁺.

Step 2: A THF (5 mL) solution of tert-butyl 2-(2-aminothiazol-4-yl)pyrrolidine-1-carboxylate (270 mg, 1 mmol) and 3-fluororbenzyl isocyanate (140 μL, 1.1 mmol) was microwave irradiated at 120 C for 60 minutes. Aqueous work-up, followed by flash chromatography afforded tert-butyl 2-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)pyrrolidine-1-carboxylate. MS (ES+): M/Z 421 (M+H)⁺, 321 (M−C₅H₈O₂)⁺.

Step 3: tert-Butyl 2-(2-aminothiazol-4-yl)pyrrolidine-1-carboxylate (870 mg, 2.1 mmol) was deprotected with trifluoroacetic acid (5 mL) in CH₂Cl₂ (20 mL). Evaporation of the reaction mixture and treatment with HCl (5 mL, 10 mmol, 2M in ether) afforded Intermediate 60: 1-(3-fluorobenzyl)-3-(4-(pyrrolidin-2-yl)thiazol-2-yl)urea hydrochloride as a white solid. ¹H NMR (400 MHz, DMSO): δ 11.93 (s, 1H, 9.96 (s, 1H), 8.85 (s, 1H), 7.76 (t, 1H), 7.38 (m, 1H), 7.1 (m, 4H), 4.56 (t, 1H), 4.37 (d, 2H), 2.30 (m, 1H), 2.08 (m, 3H). MS (ES+): M/Z 321 (M+H)⁺.

Intermediate 61: 1-(4-(((3,5-Dimethylisoxazol-4-yl)methylamino)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea

Step 1: Sodium azide (390 mg, 6.0 mmol) was added to a DMSO (5 mL) solution of Intermediate 4: 1-(4-(chloro-methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea (600 mg, 2 mmol). The mixture was stirred for 4 hours at 40 C. Upon completion of the reaction, water was added at 10 C and the mixture was extracted with EtOAc. Organics were washed with brine, dried and evaporated. Recrystallization from CH₂Cl₂/hexane afforded 1-(4-(azidomethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea. ¹H NMR (400 MHz, CDCl₃): δ 10.3 (1H, br), 7.27 (m, 1H), 7.1-6.9 (m, 3H), 6.74 (s, 1H), 4.50 (d, 2H), 4.27 (s, 2H). MS (ES+): M/Z 307 (M+H)⁺.

Step 2: Trimethylphosphine (107 μL, 1.2 mmol) was added dropwise to a THF (5 mL) solution of 1-(4-(azidomethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea (307 mg, 1.0 mmol) at 0 C under a nitrogen atmosphere. The mixture was stirred for 22 hours then HCl (0.5 mL, 4M in water) was added and the stirring was continued for 22 hours. Upon evaporation of the mixture, the product was recrystallized from acetonitrile to afford 1-(4-(aminomethyl) thiazol-2-yl)-3-(3-fluorobenzyl)urea hydrochloride. ¹H NMR (400 MHz, CD₃OD): δ 10.3 (1H, br), 7.34 (m, 1H), 7.17-6.95 (m, 4H), 4.45 (s, 2H), 4.08 (s, 2H). MS (ES+): M/Z 281 (M+H)⁺.

Step 3: NaBH₄ (35 mg, 1 mmol) was added in portions to a MeOH (5 mL) solution of 3,5-dimethylisoxazole-4-carbaldehyde (65 mg, 0.5 mmol) and 1-(4-(aminomethyl) thiazol-2-yl)-3-(3-fluorobenzyl)urea hydrochloride (157 mg, 0.5 mmol) at 0 C. The mixture was stirred for 6 hours then quenched with dilute HCl solution. Basic aqueous work-up with CH₂Cl₂ followed by flash chromatography afforded Intermediate 61: 1-(4-(((3,5-dimethylisoxazol-4-yl)methylamino)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea. ¹H NMR (400 MHz, CDCl₃): δ 8.2 (1H, br), 7.27 (m, 1H), 6.92 (m, 3H), 6.60 (s, 1H), 4.37 (d, 2H), 3.66 (s, 2H), 3.33 (s, 2H), 2.22 (s, 3H), 2.11 (s, 3H). MS (ES+): M/Z 390 (M+H)⁺.

Intermediates 62-65: Not used Intermediate 66: Chlorobenzo[1,3]dioxol-5-ylmethylamine (alt. name: 5-Chloro-piperonyl amine)

Step 1: 5-Chloropiperonal was prepared by the literature method (Berichte der Deutschen Chemischen Gesellschaft, 43, 2605-2606 (1911)).

Step 2: Reductive amination of 5-chloropiperonal was performed by borane reduction of the O-methyloxime derivative by literature method (J. Org. Chem. 34(6), 1817-1821, (1969)).

Intermediate 67: Not used Intermediate 68: 1-(3-Fluorobenzyl)-3-(3-methylaminomethyl-[1,2,4]thiadiazol-5-yl)-urea

Step 1: To a solution of triphosgene (2.37 g, 8 mmol) in CH₂Cl₂ (48 mL) was added dropwise a mixture of 3-fluorobenzylamine (2.0 g, 16 mmol) and DIPEA (4.14 g, 32 mmol) in CH₂Cl₂ (32 mL) over 2 hours at 0 C under N₂ atmosphere. After addition was complete, the mixture was refluxed for 1 hour and then cooled to ambient temperature. The mixture was washed with aq. KHSO₄, brine, dried over Na₂SO₄, and concentrated to give 3-fluorobenzyl isocyanate as a yellow liquid (1.34 g, yield 100%), which was used in the next step without further purification.

Step 2: 3-Fluorobenzyl isocyanate (1.3 g, 8 mmol) was added into a mixture of Intermediate 38: 3-chloromethyl-[1,2,4]thiadiazol-5-ylamine (0.83 g, 5.5 mmol), and DMAP (22 mg, 0.14 mmol) in NMP (11 mL). The reaction mixture was heated in a microwave reactor for 1 hour at 100 C and then cooled to ambient temperature. The reaction mixture was diluted with EtOAc (75 mL) and washed with water (30 mL×2). The aqueous phase was extracted with EtOAc (40 mL×2). The combined organic layers were washed with brine, dried over Na₂SO₄, filtered and evaporated to give the crude product, which was purified by silica gel column chromatography to afford 1-(3-chloromethyl-[1,2,4]thiadiazol-5-yl)-3-(3-fluoro-benzyl)-urea as an off-white solid (1.2 g, 72%). LC-MS (m/z): 303.0 (M+H)

Step 3: A solution of the urea obtained above (8.5 g, 28.3 mmol) and excess methylamine (27% alcohol solution, 54 mL) was heated in a microwave reactor for 15 minutes at 60 C. After cooling to room temperature, a solution of K₂CO₃ (1.8 g) in water (5 mL) was added, and the volatiles were removed in vacuo. The crude product was purified by column chromatography DCM:MeOH:Et₃N=20:1:0.151 to give Intermediate 68: 1-(3-fluorobenzyl)-3-(3-methyl aminomethyl-[1,2,4]thiadiazol-5-yl)-urea as a yellowish solid (4.4 g, yield: 52.7%, purity detected by LC-MS: >97%). ¹H NMR (400 MHz, DMSO-d₆) δ: 7.95 (s, 1H), 7.90 (s, 1H), 7.37 (m, 1H), 7.10 (m, 3H), 4.37 (d, J=5.6 Hz, 2H), 3.71 (s, 2H), 2.31 (s, 3H).

Intermediate 69: 1-(5-Chloro-thiophen-2-ylmethyl)-3-(3-methylaminomethyl-[1,2,4]thiadiazol-5-yl)-urea

Step 1: To a solution of triphosgene (1.15 g, 3.9 mmol) in CH₂Cl₂ (30 mL) was added dropwise a mixture of (5-chlorothiophen-2-yl)methanamine (1.14 g, 7.8 mmol) and DIPEA (2.0 g, 15.6 mmol) in CH₂Cl₂ (32 mL) over 2 hours at 0 C under N₂ atmosphere. After addition was complete, the mixture was refluxed for 1 hour and then cooled to ambient temperature. The mixture was washed with aq. KHSO₄, brine, dried over Na₂SO₄, and concentrated to give 5-chlorothiophen-2-yl-methyl isocynate a yellow liquid (1.34 g, yield 100%), which was used in the next step without further purification.

Step 2: The isocyanate obtained above was added into a mixture of Intermediate 38: 3-chloromethyl-[1,2,4]thiadiazol-5-ylamine (0.96 g, 6.4 mmol), and DMAP (26 mg, 0.17 mmol) in NMP (7 mL). The reaction mixture was heated in a microwave reactor for 1 hour at 100 C and then cooled to ambient temperature. The reaction mixture was diluted with EtOAc (50 mL) and washed with water (20 mL×2). The aqueous phase was extracted with EtOAc (25 mL×2). The combined organic layers were washed with brine, dried over Na₂SO₄, filtered and evaporated to give the crude product, which was purified by silica gel column chromatography [petroleum ether:EtOAc (PE:EA)=3:1] to give 1-(3-chloromethyl-[1,2,4]thiadiazol-5-yl)-3-(5-chloro-thiophen-2-ylmethyl)-urea as a brown oil (1.74 g, 70%).

Step 3: A solution of the urea obtained above (7.33 g, 22.7 mmol) and excess methylamine (27% alcohol solution, 36 mL) was heated in a microwave oven for 15 minutes at 60 C. After having been cooled to room temperature, a solution of K₂CO₃ (1.7 g) in water (3 mL) was added and the volatiles were removed in vacuo. The crude product was purified by column chromatography [EtOAc, then DCM:MeOH:Et₃N=20:1:0.15] to give Intermediate 69: 1-(5-chloro-thiophen-2-ylmethyl)-3-(3-methylaminomethyl-[1,2,4]thiadiazol-5-yl)-urea as a yellowish solid (2.22 g, yield: 31%). ¹H NMR (400 MHz, DMSO-d₆) δ: 7.74 (s, 1H), 6.94 (d, J=4.0 Hz, 1H), 6.85 (d, J=3.2 Hz, 1H), 4.42 (d, J=6.0 Hz, 2H), 3.70 (s, 2H), 2.31 (s, 3H).

Intermediate 70: 1-(2,4-Dimethoxy-benzyl)-3-(3-fluoro-benzyl)-1-(3-methylamino-methyl-[1,2,4]thiadiazol-5-yl)-urea

Step 1: A solution of 5-chloro-3-chloromethyl-[1,2,4]thiadiazole (3 g, 18 mmol, [74461-64-6]) in DCM (20 mL) was treated with DIPEA (1 eq), followed by 2,4-dimethoxybenzylamine (1 eq). After stirring overnight, the mixture was concentrated and purified by silica gel chromatography (10% MeOH/EtOAc) to afford (3-chloromethyl-[1,2,4]thiadiazol-5-yl)-(2,4-dimethoxy-benzyl)-amine, which was used directly in the next step.

Step 2: The amine obtained above was dissolved in THF (45 mL) and treated with 3-fluorobenzylisocyanate (1 eq). The resulting solution was heated at 140 C for 20 minutes in a sealed tube. The reaction mixture was concentrated and purified by silica gel chromatography (50% EtOAc/hexanes to afford 1-(3-chloromethyl-[1,2,4]thiadiazol-5-yl)-1-(2,4-dimethoxy-benzyl)-3-(3-fluoro-benzyl)-urea (3.8 g, 47% yield for two steps).

Step 3: The urea product obtained above (1.0 g, 2.2 mmol) was dissolved in a solution of 33% methylamine in ethanol. The solution was heated in a sealed tube at 60 C for 15 minutes, then concentrated and purified by silica gel chromatography (4% 7N ammonia/MeOH: 96% DCM) to afford Intermediate 70: 1-(2,4-dimethoxy-benzyl)-3-(3-fluoro-benzyl)-1-(3-methylamino-methyl-[1,2,4]thiadiazol-5-yl)-urea, as a white solid (825 mg, 83% yield).

End of Intermediates.

Example 477 Synthesis Methods For Compounds of Tables 1-3 Method 1: BOC Deprotection Method using TFA

The BOC-protected thiazole urea analog (0.2-0.5 mmol) was dissolved in trifluoroacetic acid (2 ml) and the solution is stirred overnight. The volatiles were removed by evaporation and the residue was triturated with ether to afford the TFA salt of the final product; or purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM. In cases where the HCl salt was desired, this was treated with HCl (4.0M in dioxane) to give the HCl salt.

Method 2: Amide Formation by TBTU Coupling of Carboxylic Acid and Amine

Carboxylic acid (0.25 mmol) was dissolved in 3 ml DMF, and TBTU (1.1 eq) and base (K₂CO₃ or DIEA, 1.1 eq.) were added. To the stirred mixture, N-alkylaminomethyl thia(dia)zolylurea was added and stirred overnight. 10 ml of water was added. If the product precipitated from the solution, it was filtered and washed with water and dried. The crude was purified by column chromatography using 0-100% gradient of 10% MeOH/EtOAc and hexanes. If the product remained in the solution, the product was extracted three times with EtOAc and back washed with brine twice. The organic was dried, concentrated and purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM.

Method 3: Amide Formation by Condensation of an Acid Chloride and Amine

Carboxylic chloride (0.25 mmol) was added to a mixture of 1.0 eq. of N-alkylaminomethylthi(dia)azolylurea and base (K₂CO₃ or DIEA, 1 eq.) in 3 ml DMF. The reaction was stirred overnight. 10 ml of water was added. If the product precipitated from the solution, it was filtered and washed with water and dried. The crude was purified by column chromatography using 0-100% gradient of 10% MeOH/EtOAc and hexanes. If the product remained in the solution, the product was extracted three times with EtOAc and back washed with brine twice. The organic was dried, concentrated and purified by column chromatography using 0-10% 7 N ammonia/MeOH and DCM.

Method 4: TBTU Coupling Followed by Deprotection with HCl

Step 1: Thiazole urea intermediate (SM1) and acid (SM2) are coupled following Method 2.

Step 2: The protected thiazole urea analog was dissolved in 4.0M HCl in dioxane and the solution is stirred 2-24 hours. Diethyl ether is added. In most cases, product precipitates and is isolated as a solid. If necessary, the product is purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM.

Method 5: Sulfonamide Formation by Condensation of a Sulfonyl Chloride and Amine

Sulfonyl chloride (SM2, 0.25 mmol) was added to a mixture of an advanced intermediate, N-alkylaminomethylthiazolylurea (SM1, 1.0 eq.) and base (K₂CO₃ or DIEA, 1.0 eq.) in 3 mL inert solvent such as DCM or THF or DMF. The reaction was stirred overnight. 10 mL of water was added. If the product precipitated from the solution, filtered and washed with water and dried. The crude was purified by column chromatography using 0-100% gradient of 10% MeOH/EtOAc and hexanes. If the product remained in the solution, the product was extracted three times with EtOAc and back washed with brine twice. The organic was dried, concentrated and purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM.

Method 6: General Method For Removing N-Fmoc Protecting Group

The advanced thia(dia)zole intermediate (0.2 mmol) bearing an N-Fmoc (N-9-Fluorenylmethyl Carbamate) protecting group was dissolved in DMF (2 mL) treated with excess morpholine (1 mL). When the reaction was complete the solution was concentrated in vacuo and purified by chromatography to afford the N-deprotected product.

Method 7: Urea Formation by Reaction of an N-Acyl-imidazolide with Amine

An N-acyl-imidazolide (SM 1, 1 mmol), typically formed by condensing a 2-aminothiazole derivative with carbonyl diimidazole, is suspended in THF (10 mL) and the amine component (SM2, 1 eq) is added. If the amine (SM2) is used in the form of a salt (ex. hydrochloride), then a base (1 eq) such as DIPEA is also added. The reaction is stirred at 20-50° C. until complete, then concentrated, and purified by chromatography (silica gel, MeOH/EtOAc) to afford the desired thiazole urea product.

Method 8: Urea Formation by Reaction of a Phenyl Carbamate with Amine

A phenylcarbamate (SM1, 1 eq.) was taken up in dioxane and the amine (SM2, 1.1 eq.) was added. The reaction was heated in the microwave at 100-140° C. until complete. The solvent was removed and the crude material was purified by column chromatography using 10% saturated ammonia/MeOH in DCM or 10% MeOH/EtOAc in hexanes to give product. In some cases, the HCl salt of the product was prepared by adding HCl in dioxane, followed by the addition of diethyl ether to give a white solid.

Method 9: Carboxylic Acid Formation by Hydrolysis of Corresponding Ester

The carboxylic acid ester is saponified with aqueous sodium hydroxide in an alcoholic cosolvent. The carboxylic acid product is isolated by acidification and aqueous work-up.

Example: Ethyl 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)-carbamoyl)-5-methylisoxazole-3-carboxylate (105 mg) was dissolved in ethanol (5 ml) and 1 N sodium hydroxide (5.0 eq) was added and stirred for 2 hours. The reaction was acidified to pH=2 and concentrated. The precipitate was filtered, washed with water and dried to give 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylic acid.

Method 10: General DMB Deprotection Method Using TFA

The advanced thia(dia)zole intermediate (0.25-0.5 mmol) with a 2,4-dimethoxybenzyl-protecting group (DMB) was dissolved in trifluoroacetic acid (4 ml) with anisole (5 drop) and the reaction was stirred at room temperature overnight. The volatiles were evaporated and the residue was purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM to afford the deprotected product.

Method 11: General Deprotection Method For O—Silyl Protecting Groups

The advanced thia(dia)zole intermediate (0.25-0.5 mmol) bearing an O-silyl protecting group (such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl) is cleaved by treatment with tetra-n-butylammonium fluoride (TBAF) in THF or ACN solvent (Can. J. Chem. 55, 562 (1977)). The deprotected product is purified by chromatography, if necessary.

Method 12: Reduction of Ester to Alcohol

A carboxylic ester is reduced with lithium borohydride in an inert solvent such as THF to afford the corresponding alcohol, after aqueous work-up and chromatography.

Example: Ethyl 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylate (60 mg) was suspended in tetrahydrofuran (6 ml) and LiBH₄ (3.0 mg) was added and stirred at room temperature overnight. Additional LiBH₄ (6.0 mg) was added and stirred overnight. The reaction was concentrated and the residue was purified by column chromatography using 0-100% gradient of 9:1 EtOAc/MeOH and hexanes.

Method 13: Preparation of 2,4-Dimethoxybenzyl-protected Amines

Step 1: Aryl aldehyde (10 mmol) was mixed with 2,4-dimethoxybenzylamine (1.0 eq.) in DCM (50 ml) and acetic acid (1.0 ml) was added. To the mixture, sodium triacetoxyborohydride (2.5 eq.) was added the mixture was stirred at room temperature overnight. The mixture was filtered through Celite and washed with DCM. The filtrate was concentrated and purified by column chromatography using 0-10% gradient of 7 N ammonia/MeOH and DCM to afford the 2,4-DMB-protected amine product.

Method 14: Alkylation of Thiazolidine-2,4-Dione

1-(3-Fluoro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea (Intermediate 7, 0.3 mmol) was taken up in THF (3 ml) and DIPEA (1 eq.) and potassium carbonate (1 eq.) was added, followed by thiazolidine-2,4-dione (1 eq.). The reaction was stirred at room temperature overnight. Solvent is removed in vacuo and the crude material was purified by column chromatography with a gradient of 0-60% of (9:1 EtOAc/MeOH) and hexanes to afford 1-(4-((2,4-dioxothiazolidin-3-yl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea (EX #109) as a white solid.

Method 15: Alkylation of Oxazolidin-2-one

Step 1: 1-(4-Chloromethyl-thiazol-2-yl)-1-(2,4-dimethoxy-benzyl)-3-(3-fluoro-benzyl)-urea (Intermediate 21, 0.3 mmol) was taken up in DMF (2 ml). A solution of the oxazolidin-2-one (or sultam) (1 eq.) with NaH (1 eq.) in DMF (2 ml) was added. The reaction was allowed to stir at room temperature for 2 hours. An aqueous workup with EtOAc was performed. Purified by column chromatography using a gradient of 0-100% EtOAc/hexanes to give 1-(2,4-dimethoxybenzyl)-3-(3-fluorobenzyl)-1-(4-((2-oxooxazolidin-3-yl)methyl)thiazol-2-yl)urea.

Step 2: The 1-(2,4-dimethoxybenzyl)-3-(3-fluorobenzyl)-1-(4-((2-oxooxazolidin-3-yl)methyl)thiazol-2-yl)urea was treated with TFA. Anisole (1 drop) was added. The reaction was stirred for 1 hour. Solvent was removed in vacuo. Purified by column chromatography with a gradient of 0-100% of 9:1 EtOAc/MeOH and hexanes. Resulting solid was triturated with diethyl ether to give the pure urea product.

Method 16: Alkylation of Isothiazolidinine 1,1-Dioxide

Intermediate 21 and isothiazolidine 1,1-dioxide were reacted and deprotected following the procedure in Method 15.

Method 17: Bromination of Thiazole 5-Position

Bromine (120 μL, 0.12 mmol, 1M in CH₂Cl₂) was added dropwise to a CH₂Cl₂ (5 mL) solution of the thiazole urea compound (0.1 mmol). The bromination was instantaneous. The mixture was washed with dilute Na₂SO₃ solution, dried and evaporated to afford the 5-bromo-compound.

Method 18: Chlorination of Thiazole 5-Position

The thiazole urea compound was taken up in DCM and treated with N-chlror-succinimide (1.2 equiv). The mixture was stirred overnight at ambient temperature. An aqueous work-up was performed with dilute sodium sulfite solution. The organic layer was filtered through a silica plug and eluted with 3% MeOH in DCM to give the 5-chloro-compound.

Method 19: Cyanation of Thiazole 5-Position

Example: A mixture of 3,5-dimethyl-isoxazole-4-carboxylic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide (Ex. 151) (100 mg, 0.2 mmol), CuCN (180 mg, 2.0 mmol) and KCN (13 mg, 0.2 mmol) in DMF (1 mL) was heated to 120 C for 5 hours. Upon cooling the mix was diluted with EtOAc (50 mL), filtered, washed with brine, dried and evaporated. Flash chromatography afforded 3,5-dimethyl-isoxazole-4-carboxylic acid {5-cyano-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide.

Method 20: Hydrolysis of Acetate Protecting Group to Afford Alcohol

The acetate thiazole urea (0.5 mmol) was dissolved in ethanol (2 ml) and 1 N sodium hydroxide (2.5 ml) was added and stirred overnight. The ethanol was removed by evaporation. If precipitation occurred, the product was isolated by filtration and washing with water. The product can be isolated by extraction of the mixture three times with EtOAc. The organic was combined and dried over sodium sulfate. The organic was filtered and washed with EtOAc and the filtrate was concentrated to dryness. The residue was purified by column chromatography using gradient of 0-10% gradient of 7 N ammonia/MeOH and DCM.

Method 21-43: Not used Method 44: Synthesis of 3-chloro-6-methoxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide

3,6-Dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide (47 mg) was treated with potassium hydroxide (56 mg) in MeOH (5 mL) over night. The resultant mixture was diluted with water (10 mL) and the pH was adjusted to 9-10 by sodium bicarbonate. After evaporation of MeOH, the resultant precipitate-3-chloro-6-methoxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was collected, briefly rinsed with water and dried. The desired product was confirmed by 1HNMR and LC-MS.

Method 45: Synthesis of 3-chloro-6-hydroxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide

3,6-Dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide (150 mg) in acetic acid (10 mL) was heated at reflux for 2 h. The resultant mixture was concentrated and purified by a preparative C-18 reverse phase HPLC. About 15 mg of the desired product-3-chloro-6-hydroxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was obtained. The desired product was confirmed by 1HNMR and LC-MS.

Method 46: Synthesis of tetrahydro-furan-2-carboxylic acid (2-amino-1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-ethyl)-methyl-amide

Tetrahydro-furan-2-carboxylic acid (cyano-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-methyl)-methyl-amide (420 mg) was dissolved in MeOH (10 mL) and treated with Raney®-Nickel under a pressurized hydrogen (45 psi) over a couple of hours until all starting materials were consumed. The final product was purified by column chromatography. The product was confirmed by ¹H NMR and LC-MS.

Method 47: Synthesis of 6-methoxy-3-methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide

N₂ was bubbled for 15 minutes through a solution of 1-(3-fluorobenzyl)-3-(4-((3-chloro-6-methoxy-N-methylpyridazine-4-carboxamido)methyl)-thiazol-2-yl)urea (118 mg, 0.25 mmol) in 1,4-dioxane. Pd(PPh₃)₄ (15 mg, 13 μmol) was added followed by AlMe₃ (250 μl, 2 M in toluene, 0.51 mmol). The mixture was refluxed for 4 hours and MeOH was added. Silica (300 mg) was added and the volatiles were removed in vacuo. The residue was brought on a column and purified by chromatography (CH₂Cl₂+5% 7N NH₃ in MeOH) to afford the title product (60 mg, 0.13 mmol) as an off-white solid in 52% yield.

Method 48: Synthesis of 6-hydroxy-3-methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide

6-Methoxy-3-methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was dissolved in DCM and treated with an excess of BBr3 at room temperature for a couple of hours. Column chromatography afforded the title product.

Method 49: Synthesis of 3-(dimethylamino)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N-methylpyridazine-4-carboxamide

3-Chloro-6-methoxypyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was treated with dimethylamine in 1,4-dioxane to afford the desired product.

Method 50: Synthesis of N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N-methyl-3-(methylamino)pyridazine-4-carboxamide

3-(Dimethylamino)-N-((2-(3-(3-fluorobenzyBureido)thiazol-4-yl)methyl)-6-methoxy-N-methylpyridazine-4-carboxamide was treated with BBr3 (12 equivalent) in DCM to afford the title product.

Method 51: Synthesis of 6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylpyridazine-4-carboxamide

Step 1: Synthesis of 6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methylpyridazine-4-carboxamide. A solution of 3,6-dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide (235 mg, 0.5 mmol) and MeOH (160 mg, 5 mmol) in 1,4-dioxane (10 mL) was added NaOH (20 mg, 0.5 mmol). The mixture was stirred overnight at room temperature and concentrated in vacuo. The residue was dissolved in CH₂Cl₂+5% MeOH and filtered over a small plug of silica. The volatiles were evaporated and the desired product (230 mg) was obtained as a 5:1 mixture with starting material-3,6-dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide. This mixture was used as such in the subsequent steps.

Step 2: Synthesis of 6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylpyridazine-4-carboxamide. A solution of 6-chloro-N-((2-(3-(3-fluorobenzyBureido)thiazol-4-yl)methyl)-3-methoxy-N-methylpyridazine-4-carboxamide (113 mg, 0.24 mmol) and NaOAc (100 mg, 1.21 mmol) in AcOH (7 mL) was heated at 100° C. overnight. The volatiles were removed in vacuo and the residue was purified by column chromatography (SiO₂, CH₂Cl₂/5% 7N NH₃ in MeOH). The title product was confirmed by ¹H-NMR and LC-MS.

End of Methods Section.

Example 478 Demonstration of Antibacterial Effect and Mechanism of Action

The polC gene from Streptococcus pyogenes was overexpressed and PolC was purified as described in PCT/US05/15548. Primer extension activity of PolC was measured using 1 μM oligonucleotide primer-template (primer strand 5′-ACCAGTGAGACGGGCAACA, template strand 5′-TGAATTATAGGCCCTGTTGCCCGTCTCACTGGT). Reactions contained 10 mM magnesium acetate, 50 mM Tricine/Tris pH 7.8, 2.4% (w/v) polyethylene glycol (8000 MW), 0.024% pluronic F68, 1 mM dithiothreitol, 20 μM dATP, 20 μM dCTP, 0.5 μM dGTP, 0.72 μM dTTP, 0.28 μM 3H-dTTP (0.005 μCi/μL), 8% DMSO and 15 nM PolC. Reactions (25 μL) were incubated for 10 minutes at room temperature and stopped by addition of an equal volume of 100 mM EDTA. Incorporation of radiolabelled dTTP was measured by scintillation proximity assay by addition of 100 μL of 1 mg/mL PEI-PVT beads in 300 mM citrate pH 3.0.

Compounds of Formula (I) were tested for inhibition of S. pyogenes PolC activity. Serial 2-fold dilutions of compounds were tested for inhibition of PolC activity and IC₅₀'s were determined (XLfit). Compounds described in Examples 1, 3-6, 8, 10-17, 19-21, 24-31, 33, 36, 38, 40, 54, 56-57, 59-71, 74-105, 107-108, 110-112, 114, 117-120, 122-142, 144-159, 162-179, 181-182, 184-225, 227-242, 244-319, 321-355, and 357-475 had IC₅₀'s of 0.01-25 μM. These compounds were specific for prokaryotic DNA polymerase, showing little or no inhibition of eukaryotic S. cerevisiae polymerase delta at concentrations up to 160 μM.

A subset of these analogs were tested for inhibition of macromolecular biosynthesis in whole cell S. aureus assays as described by Ochsner, et al. (Antimicrob Agents Chemo. 49:4253-62 (2005)). All tested analogs were potent inhibitors of DNA synthesis, with IC₅₀'s of <0.06-4.5 μg/mL; the compounds showed little or no inhibition of other macromolecular synthesis pathways (RNA, protein or cell wall biosynthesis) at concentrations as high as 64 μg/mL.

Compounds of the present invention were tested for antibacterial activity against a variety of pathogenic organisms including S. aureus, S. pneumoniae, S. pyogenes, E. faecalis, H. influenza and M. catarrhalis using a standard broth microdilution method to determine their minimum inhibitory concentrations (MICs). All compounds were tested using standard methods in accordance with CLSI guidelines (Clinical and Laboratory Standards Institute). Compounds described in Examples 1, 3-6, 8, 10-17, 19-21, 24-31, 33, 36, 38, 40, 54, 56-57, 59-71, 74-105, 107-108, 110-112, 114, 117-120, 122-142, 144-159, 162-179, 181-182, 184-225, 227-242, 244-319, 321-355, and 357-475 had MIC's of <0.12-4.0 μg/mL against some strains of the major Gram-positive organisms S. aureus, S. pneumoniae, S. pyogenes, and E. faecalis. The compounds showed weak Gram-negative activity with MICs of 1->128 μg/mL against some strains of the major Gram-negative organisms E. coli tolC, P. aeruginosa, H. influenze and M. catarrhalis. Compounds described in Examples 11, 54, 60, and 208 shown to be bactericidal in S. aureus, E. faecalis, E. faecium, S. pyogenes, S. epidermidis and S. pneumoniae.

Compounds of the present invention were not compromised by existing resistance to all drug classes tested, including β-lactams, glycopeptides, oxazolidinones, macrolides, and fluoroquinolones. In particular, compounds described in Examples 11, 54, 60, and 208 were active against methicillin-(oxacillin-) resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA), linezolid-resistant S. aureus, methicillin-(oxacillin-) resistant and mupirocin resistant S. epidermidis, macrolide-resistant S. pyogenes, macrolide-, penicillin-, and levofloxacin-resistant S. pneumoniae, vancomycin-, macrolide-, and ciprofloxacin-resistant E. faecalis (VRE) and vancomycin-, macrolide-, and ciprofloxacin-resistant E. faecium. MICs were comparable in sensitive versus drug resistant strains, and ranged from 0.25-4 μg/mL in clinically relevant resistant strains.

Compounds of the present invention showed broad spectrum antibacterial activity against Gram-positive bacteria. Compounds described in Examples 54, 60, 96, 107, 208, and 214 exhibited MIC₉₀'s ranging from 1-4 μg/mL for methicillin-(oxacillin-) resistant S. aureus (MRSA), vancomycin-resistant E. faecalis (VRE), vancomycin-resistant E. faecium, penicillin-intermediate S. pneumoniae and macrolide-resistant S. pyogenes.

It will be clear that the invention is well adapted to attain the ends and advantages mentioned as well as those inherent therein. While several presently preferred embodiments have been described for purposes of this disclosure, various changes and modifications may be made which are well within the scope of the invention. Numerous other changes may be made which will readily suggest themselves to those skilled in the art and which are encompassed in the spirit of the invention disclosed herein and as defined in the appended claims.

The entire disclosure and all publications cited herein are hereby incorporated by reference. 

What is claimed is:
 1. A compound of Formula (I):

in which: R₁ is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl; X is selected from the group consisting of a C and N atom; Y is selected from the group consisting of CO and SO₂; R₂, R₃ and R₄ are independently selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and R₅ is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R₅ is null when X is N; wherein R₂, R₄, Y and N or R₂, R₃, CH and N do not form a substituted or unsubstituted 4-7 member saturated ring.
 2. A compound of Formula (I):

in which: R₁ is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl; X is selected from the group consisting of a C and N atom; Y is selected from the group consisting of CO and SO₂; R₃ is selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and R₅ is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R₅ is null when X is N, wherein R₂, R₄, Y and N form a substituted or unsubstituted 4-7 member saturated ring.
 3. A compound of Formula (I):

in which: R₁ is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl; X is selected from the group consisting of a C and N atom; Y is selected from the group consisting of CO and SO₂; R₄ is selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and R₅ is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R₅ is null when X is N, wherein R₂, R₃, CH and N form a substituted or unsubstituted 4-7 member saturated ring.
 4. The compound of claim 1, wherein R₁ is a substituted or unsubstituted phenyl or thiophene group.
 5. The compound of claim 4, wherein R₁ is a phenyl group having one or more substituents selected from the group consisting of halogen, cyano, (C₁₋₆)alkyl, mono to perfluoro(C₁₋₃)alkyl, (C₃₋₇)cycloalkyl, (C₂₋₆)alkenyl, (C₁₋₆)alkoxy, (C₂₋₆)alkenoxy, hydroxy, amino, mono- or di-(C₁₋₆)alkylamino, acylamino, nitro, carboxy, (C₁₋₆)alkoxycarbonyl, (C₁₋₆)alkenyloxycarbonyl, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkyl, carboxy(C₁₋₆)alkyl, (C₁₋₆)alkylcarbonyloxy, carboxy(C₁₋₆)alkyloxy, (C₁₋₆)alkoxycarbonyl(C₁₋₆)alkoxy, (C₁₋₆)alkylthio, (C₁₋₆)alkylsulphinyl, (C₁₋₆)alkylsulphonyl, sulphamoyl, mono- and di-(C₁₋₆)-alkylsulphamoyl, and carbamoyl.
 6. The compound of claim 1, wherein R₁ is selected from the group consisting of 3-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3-iodophenyl, 4-iodophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-4-methylendioxyphenyl, 3-4-difluorophenyl, 3-4-dichlorophenyl, 3-4-dibromophenyl, 3-4-dimethylphenyl, 3-4-(—CH₂CH₂CH₂—)phenyl, 3-4-(—OCH₂CH₂O—)phenyl, 3-chloro-4-fluorophenyl, benzo[1,3]dioxyl-5-yl, and 3-3-cyanophenyl, 3,5-difluorophenyl, thiophen-2-yl, thiophen-3-yl, 4,5-di-bromo-thiophen-2yl, 5-chloro-thiophen-2yl, and 5-bromo-thiophen-2yl, 5-fluoro-thiophen-2-yl, 5-chloro-thiophen-3-yl, 1,1,-difluoro-benzo[1,3]dioxyl-5-yl, 7-chlorobenzo[1,3]dioxol-5-yl, 3-nitrophenyl, 2,1,3-benzoxadiazol-5-yl, and 4-nitrophenyl.
 7. The compound of claim 1, wherein Y is a CO group.
 8. The compound of claim 7, wherein X is C atom.
 9. The compound of claim 7, wherein X is N atom.
 10. The compound of claim 1, wherein Y is a SO₂ group.
 11. The compound of claim 10, wherein X is a C atom.
 12. The compound of claim 10, wherein X is an N atom.
 13. The compound of claim 1, wherein R₂ is selected from the group consisting of H, methyl, ethyl, 2-hydroxyethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, 2-methanesulfonylaminoethyl, 2,2-Difluoro-ethyl, and 3,5-dimethylisoxazole-4-yl-methyl.
 14. The compound of claim 1, wherein R₃ is selected from the group consisting of H, methyl, ethyl, 2-hydroxyethyl, 2-hydroxymethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, and 2-methanesulfonylaminoethyl.
 15. The compound of claim 1, wherein R₄ is selected from the group consisting of methyl, 2-(2-methoxyethoxy)-methyl, 2-methoxymethyl, 4-methylisoxazole-5-yl, isoxazole-5-yl, 3-phenylpropanyl, furan-2-yl, 4-phenoxybutanyl, 1,1-dioxo-tetrahydro-1-lamda6-thiophen-3-ylmethylaminoyl, 3,5-dimethylisoxazole-4-yl, 1-methyl-1H-imidazole-5-yl, furan-3-yl, 3-methylfuran-2-yl, 5-methyl-3-phenylisoxazole-4-yl, 5-methyl-2-phenyl-2H-1,2,3-triazole-4-yl, 5-methylisoxazole-3-yl, 3-methyl-5-phenylisoxazole-4-yl, 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-yl, 2-(2H-tetrazol-5-yl)methyl, benzofuran-2-yl, 1,2,5-oxadiazole-3-yl, (3,5-dimethylisoxazol-4-yl)-methyl, 3-methylisoxazole-4-yl, 5-methylisoxazole-4-yl, 5-cyclopropyl-isoxazole-4-yl, 2,6-dimethylphenyl, 5-(furan-2-yl)-isoxazole-3-yl, 2,5-dimethyloxazole-4-yl, 2-phenylthiazole-4-yl, 2-(thiophen-2-yl)thiazole-4-yl, 3-hydroxy-isoxazole-5-yl, 5-phenyl-1,3,4-oxadiazole-2-yl, 5-methylfuran-2-yl, 4-methyl-1,2,5-oxadiazole-3-yl, 4-methyl-2-(pyrazin-2-yl)thiazole-5-yl, 2,4-dimethoxy-phenyl, 4-methoxy-phenyl, 3,4-dimethoxy-phenyl, benzo[1,3]dioxole-5-yl, 3,4,5-trimethoxy-phenyl, 5-methyl-3-(trifluoromethyl)isoxazole-4-yl, pyridin-3-ylmethyl, 2,4-dimethylpyridine-3-yl, 2,4,6-trimethylphenyl, 5-(methoxymethyl)-3-methylisoxazole-4-yl, 2-methoxy-methyl, 2-methoxyformyl, 3-ethyl-5-methylisoxazole-4-yl, pyrimidine-5-yl, pyrazine-2-yl, 5-methylpyrazine-2-yl, furan-3-yl, 4-methyloxazole-5-yl, 2-tosylmethyl, 3-ethylcarboxy-5-methylisoxazole-4-yl, 3-carboxy-5-methylisoxazole-4-yl, 2-methylpyridine-3-yl, 4-methylpyridine-3-yl, 3-chloro-4-(methylsulfonyl)thiophene-2-yl, 4-methylthiazole-5-yl, 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-yl, 4-methyl-2-(methylthio)pyrimidine-5-yl, 2-methylprop-1-enyl, 2-methylphenyl, quinoxaline-2,3-methylpyridine-4-yl, 3-methylisoxazole-4-yl, 4-amino-pyrimidine-5-yl, 2-amino-4-methylpyrimidine-5-yl, 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-yl, 2,4,6-trimethylpyrimidine-5-yl, 3-methylpyrazine-2-yl, 4-Boc-amino-1-methyl-1H-imidazole-2-yl, 4-amino-1-methyl-1H-imidazole-2-yl, 4-acetamido-1-methyl-1H-imidazole-2-yl, 4,6-dimethylpyrimidine-5-yl, 3-(hydroxymethyl)-5-methylisoxazole-4-yl, 3-methylpyridine-2-yl, 2-amino-4,6-dimethylpyrimidine-5-yl, 2-methylimidazo[1,2-a]pyridine-3-yl, tetrahydrofuran-2-yl, 2-methoxypyridine-3-yl, tetrahydrofuran-3-yl, methoxyformyl, 2-chloropyridine-3-yl, 1,3,5-tetramethyl-1H-pyrazole-4-yl, (S)-tetrahydrofuran-2-yl, (R)-tetrahydrofuran-2-yl, 3-propoxypyridine-4-yl, N-Boc-morpholine-2-yl, morpholine-2-yl, pyridazine-4-yl, 3,5-dimethyl-1H-pyrazole-4-yl, pyridazine-3-yl, tetrahydro-2H-pyran-4-yl, 1,5-dimethyl-1H-pyrazole-4-yl, morpholine-3-yl, 4-methylpyrrolidine-3-yl, (S)-pyrrolidine-2-yl, 1,1-Dioxo-tetrahydro-1-lamda6-thiophene-3-yl, 4-methylphenyl, methyl, ethyl, propyl, butyl, cyclopropyl, and 1,1-Dioxo-1-isothiazolidin-2-yl, 2-methyl-5,6-dihydro-4H-pyran-3-yl, 2-methyl-5-morpholin-4-ylmethyl-furan-3-yl, 2-methyl-but-2-enyl, [1,2,3]thiadiazole-4-yl, 2-pyridin-3-yl-thiazole-4-yl, 2,5-dimethyl-2H-pyrazole-3-yl, 4-methyl-furazan-3-yl, 2-morpholin-4-ylmethyl-furan-3-yl, 1-methyl-pyrrolidine-2-yl, 1-methyl-1H-pyrrole-2-yl, 1,5-dimethyl-1H-[1,2,3]triazole-4-yl, 5-fluoro-thiophene-2-yl, 4-methyl-pyrimidine-5-yl, 4-methyl-2-phenyl-pyrimidine-5-yl, 2-methylsulfanyl-nicotinyl, acetonitrile, 6-morpholin-4-yl-nicotinyl, 4-methyl-thiazole-5-yl, 3-methyl-1H-pyrazole-4-yl, 2,4-dimethyl-pyrimidine-5-yl, 2-methyl-[1,6]naphthyridine-3-yl, 6-(4-methoxy-phenyl)-pyridazine-3-yl, 2,6-bis-dimethylamino-pyrimidine-4-yl, 2,6-di-morpholin-4-yl-pyrimidine-4-yl, 3-pyridin-3-yl-acrylonitrile-2-yl, 2-methyl-[1,8]naphthyridine-3-yl, 2-dimethylamino-6-methyl-pyrimidine-4-yl, acetic acid 1-yl-ethyl ester, 1-ethyl-3-methyl-1H-pyrazole-4-yl, 2-methyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-hydroxy-ethyl, 1-ethyl-5-methyl-1H-pyrazole-4-yl, 5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-methyl-1H-indole-3-yl, 1-methyl-1H-indazole-3-yl, pyrazolo[1,5-a]pyridine-3-yl, 2-furan-2-yl-oxo, 5-oxo-pyrrolidine-2-yl, 4-methyl-pyridazine-3-yl, 5-methyl-pyridazine-4-yl, 3-amino-1H-pyrazole-4-yl, 3,6-dimethoxy-pyridazine-4-yl, 3,6-dichloro-pyridazine-4-yl, pyridine-3-yl, pyridine-2-yl, 1-methyl-1H-imidazole-4-yl, 1,2-dimethyl-1H-imidazole-4-yl, pyridin-3-yl-methyl, 3-chloro-6-methoxy-pyridazin-4-yl, 3,5-dimethyl-pyridazin-4-yl, 1-methyl-3-trifluoromethyl-1H-pyrazol-4-yl, 3-chloro-6-hydroxy-pyridazin-4-yl, 2-methyl-tetrahydrofuran-2-yl, 4-chloro-1-methyl-1H-pyrazol-3-yl, 5-chloro-1-methyl-1H-pyrazol-4-yl, 4-chloro-2-methyl-2H-pyrazol-3-yl, 4-chloro-1H-pyrazol-3-yl, 1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-3-yl, 2-methyl-5-sulfamoyl-phenyl, 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl, 1-phenyl-cyclobutyl, 3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl, 7-chloro-benzo[1,3]dioxol-5-yl, 6-[1,2,4]triazol-1-yl-pyridin-3-yl, 1-(2-methoxyethyl)-6-oxo-1,6-dihydropyridazin-3-yl, 2-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)methyl, 6-chloro-3-hydroxy-pyridazin-4-yl, 3-cyano-2-hydroxy-6-methyl-pyridin-4-yl, 1-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl, 4-oxo-3,4-dihydrophthalazin-1-yl, 4,6-dimethyl-2-oxo-2H-pyran-5-yl, 1-methyl-4-sulfamoyl-1H-pyrrol-2-yl, (5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl, 3,6-dimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidin-5-yl, 5-methyl-4-oxo-3,4-dihydrothieno[2,3-b]pyrimidin-6-yl, phenyl-difluoromethyl, 4-hydroxyl-1-carbamoyl-pyrrolidin-2-yl, 2-(1-morpholino)-pyridin-3-yl, 1-(3-fluorophenyl)-cyclobutyl, 1-methyl-5-trifluoromethyl-1H-pyrazol-4-yl, (S)-1-methoxyethyl, 3-methyl-5,6-dihydro-1,4-dioxin-2-yl, (R)-5-oxo-tetrahydrofuran-2-yl, 5-chloro-1,3-dimethyl-1H-pyraozol-4-yl, 2-methoxy-ethyl, 1-(2-hydroxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, (R)-1-methoxy-ethyl, 1-(2-methoxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, tetrahydro-2H-pyran-2-yl, 3,6-dimethylisoxazolo[5,4-b]pyridine-4-yl, 5-methoxy-tetrahydrofuran-2-yl, 1-(4-methoxybutyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(3-methoxypropyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(4-fluorophenyl)-cyclobutyl, 5-methyl-tetrahydrofuran-2-yl, 3-methyl-oxetan-3-yl, 5-chloro-1H-pyrazol-4-yl, (R)-2,2-dimethyl-1,3-dioxolan-4-yl, (S)-2,2-dimethyl-1,3-dioxolan-4-yl, 3,6-dichloro-5-methyl-pyridazin-4-yl, 6-methoxyl-3-methyl-pyridazin-4-yl, 1-methyl-5-nitro-1H pyrazol-4-yl, 2,3-dihydrobenzofuran-2-yl, 6-hydroxy-3-methyl-pyridazin-4-yl, 2-(1-pyrrolidinyl)-pyridin-3-yl, 3-oxo-3-(2-thiophenyl)-propyl, 3-oxo-3-phenyl-propyl, 3-fluoro-4-methoxy-benzyl, 3,4-dimethoxy-benzyl, 4-(hydroxymethyl)-phenoxy-methyl, 3-methylsulfonyl-benzyl, 2-mercapto-4-methyl-thiazol-5-yl, 5-trifluoromethyl-furan-2-yl, 6-hydroxy-3-methylamino-pyridazin-4-yl, 3-(dimethylamino)-6-methoxy-pyridazin-4-yl, 2,2-dimethyl-tetrahydro-2H-pyran-4-yl, 4-(dimethylamino)-benzyl, 7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl, 1H-benzoimidazol-2-yl, naphthalene-2-yl-methyl, 4-methoxy-3-methyl-benzyl, 1-amino-2-benzyloxy-ethyl, 1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl, 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-methyl, 5-nitro-1H-pyrazol-4-yl, (S)-3,3-difluoro-tetrahydrofuran-2-yl, chroman-2-yl, 3,5-dimethyl-1H-pyrazol-4-yl, 4-butynyl, 2-methyl-1,2,34-tetrahydroisoquinolin-3-yl, (S)-2-(4-pyridinyl), 1-amino-ethyl, cis-3-methoxy-tetrahydrofuran-2-yl, 1-cyano-cyclopropyl, ethynyl, 1-ethoxy-ethyl, 1-(4-methoxy-phenoxy)ethyl, 1-(cyclopropylmethoxy)ethyl, 1,4-diamino-butyl, 1-(2-phenoxyethoxy)ethyl, cyclopropylmethyl, 3-ethyl-3-oxetan-3-yl, 1-(2,2-difluoroethoxy)ethyl, 1-(4-fluoro-benzyloxy)ethyl, 1-(2,2,2-trifluoroethoxy)ethyl, 1-(prop-2-ynyloxy)ethyl, 5-methyl-isoxazol-3-yl, 1-((1-methyl-pyrrolidin-3-yl)oxy)ethyl, 1-(2-hydroxyethoxy)ethyl, cyclopentyl, 1-hydroxy-cyclopropyl, cyclohexyl, 2-methyl cyclohexyl, 2-oxo-2,3-dihydrobenzoxazol-6-yl, 2,2,2-trifluoroethyl, 1-hydroxy-1-methyl-ethyl, (R)-5-(hydroxymethyl)tetrahydrofuran-2-yl, (4-hydroxy-2-oxo-pyrrolidin-1-yl)methyl, 1,2,2,2-tetrafluoroethyl, 1-carbamoyl-cyclopropyl, 2-methyl-cyclopropyl, 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl, 5-isopropyl-3-methyl-isoxazol-4-yl, and 1,3,5-trimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl.
 16. The compound of claim 2, wherein R₂, R₄, Y and N together form 2,4-dioxothiazolidin-3-yl.
 17. The compound of claim 2, wherein R₂, R₄, Y and N together form 2-oxooxazolidin-3-yl.
 18. The compound of claim 3, wherein R₂, R₃, CH and N together form 4-aceoxy-1-(methylsulfonyl)pyrrolidin-2-yl.
 19. The compound of claim 3, wherein R₂, R₃, CH and N together form 4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl.
 20. A compound selected from the group consisting of: N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)acetamide; 3-(N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)acetamido)propylphosphonic acid; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-methoxyethoxy)-N-methylacetamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylisoxazole-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-phenylpropanamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-2-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-phenoxybutanamide; 1-(3,4-Dichloro-benzyl)-3-{4-[3-(1,1-dioxo-tetrahydro-1,6-thiophen-3-ylmethyl)-1-methyl-ureidomethyl]-thiazol-2-yl}-urea; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylfuran-2-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-phenylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-ethyl-3,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-isopropyl-3,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-phenylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2H-tetrazol-5-yl)acetamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzofuran-2-carboxamide; N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)ethyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,2,5-oxadiazole-3-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(3,5-dimethylisoxazol-4-yl)-N-methylacetamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-ethyl-N,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; 5-cyclopropyl-N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,6-trimethylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(furan-2-yl)-N-methylisoxazole-3-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,5-trimethyloxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylthiazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2,4-dimethoxybenzyl)-3,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)-3,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(thiophen-2-yl)thiazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylisoxazole-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-phenyl-1,3,4-oxadiazole-2-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylfuran-2-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-1,2,5-oxadiazole-3-carboxamide; 4-Methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid {2-[3-(3,4-dichlorobenzyl)ureido]-thiazol-4-ylmethyl}-methyl-amide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2,4-dimethoxy-N-methylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-4-methoxy-N-methylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4-dimethoxy-N-methylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4,5-trimethoxy-N-methylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-(trifluoromethyl)isoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyridin-3-yl)acetamide; N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-(methylamino)-2-oxoethyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylbenzamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carb oxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide; methyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)amino)-2-oxoacetate; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide; 3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyrazine-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyloxazole-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-tosylacetamide; Ethyl 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylate; 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylic acid; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylnicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylnicotinamide; 3-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-(methylsulfonyl)thiophene-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylthiazole-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-2-(methylthio)pyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylbut-2-enamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylbenzamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylquinoxaline-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpicolinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-((4-methoxybenzyloxy)methyl)-N,3-dimethylisoxazole-4-carboxamide; N-(2-Aminoethyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethylisoxazole-4-carboxamide; 4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide; 2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethyl-N-(2-(methylsulfonamido)ethyl)isoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylpyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; tert-butyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-1-methyl-1H-imidazol-4-ylcarbamate; 4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide; 4-acetamido-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-(hydroxymethyl)-N,5-dimethylisoxazole-4-carboxamide; N-((2-(3-(4-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide; N-((2-(3-(3-chlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(benzo[1,3]dioxol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; 2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide; N-((2-(3-((2,2-difluorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylimidazo[1,2-a]pyridine-3-carboxamide; N,3,5-trimethyl-N-((2-(3-(3-(N-methylacetamido)benzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; 1-(4-((2,4-dioxothiazolidin-3-yl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylnicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-3-carboxamide; N,3,5-trimethyl-N-((2-(3-(thiophen-3-ylmethyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; methyl (2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl(2-hydroxyethyl)carbamate; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3-methylisonicotinamide; 1-(3-fluorobenzyl)-3-(4-((2-oxooxazolidin-3-yl)methyl)thiazol-2-yl)urea; 2-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylnicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,5-tetramethyl-1H-pyrazole-4-carboxamide; (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-propoxypicolinamide; tert-butyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)morpholine-4-carboxylate; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-2-carboxamide; N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,5-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-((5-chlorofuran-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrrolidine-3-carboxamide; (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrrolidine-2-carboxamide; 2-Methyl-5,6-dihydro-4H-pyran-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Methyl-5-morpholin-4-ylmethyl-furan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Methyl-but-2-enoic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,2,3-Thiadiazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Pyridin-3-yl-thiazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Methyl-furazan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Morpholin-4-ylmethyl-furan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Methyl-pyrrolidine-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Methyl-1H-pyrrole-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,5-Dimethyl-1H-[1,2,3]triazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5-Fluoro-thiophene-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Methyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Methyl-2-phenyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-2-methylsulfanyl-nicotinamide; 2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide; 3,5-Dimethyl-isoxazole-4-carboxylic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-morpholin-4-yl-nicotinamide; 4-Methyl-thiazole-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2,4-Dimethyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Methyl-[1,6]naphthyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 6-(4-Methoxy-phenyl)-pyridazine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-pyrazine-2-carboxylic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-pyrazine-2-carboxylic acid {5-chloro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2,6-Bis-dimethylamino-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-3-pyridin-3-yl-acrylamide; 2-Methyl-[1,8]naphthyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Dimethylamino-6-methyl-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-methoxy-N-methyl-2-phenyl-acetamide; 3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-pyrazine-2-carboxylic acid methyl-[2-(3-thiophen-3-ylmethyl-ureido)-thiazol-4-ylmethyl]-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid {5-cyano-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Acetic acid 1-({2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-carbamoyl)-ethyl ester; 1-Ethyl-3-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Methyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-hydroxy-N-methyl-propionamide; 3,5-Dimethyl-isoxazole-4-carboxylic acid (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-ethyl)-amide; 1-Ethyl-5-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5,7-Dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-2-hydroxy-ethyl)-amide; 1-Methyl-1H-indole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Methyl-1H-indazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Pyrazolo[1,5-a]pyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-furan-2-yl-N-methyl-2-oxo-acetamide; 3,5-Dimethyl-isoxazole-4-carboxylic acid [2-(3-benzyl-ureido)-thiazol-4-ylmethyl]-methyl-amide; 3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-5-isopropyl-thiazol-4-ylmethyl}-methyl-amide; 5-Oxo-pyrrolidine-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid (2,2-difluoro-ethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-amide; 4-Methyl-pyridazine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5-Methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Amino-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,6-Dimethoxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; (3,5-Dimethyl-isoxazol-4-ylmethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-carbamic acid methyl ester; (R)-Tetrahydro-furan-2-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5-Methyl-pyridazine-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5-Methyl-pyridazine-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Tetrahydro-furan-2-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,6-Dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Chloro-6-methoxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; (R)-Tetrahydro-furan-2-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{5-Fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Chloro-6-hydroxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 2-Methyl-tetrahydro-furan-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 4-Chloro-1H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3,5-Dimethyl-isoxazole-4-carboxylic acid (cyano-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-methyl)-methyl-amide; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,3,6-Trimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; 1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Phenyl-cyclobutanecarboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; 1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-methylacetamide; 1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {2-[3-(5-chlorothiophen-2-yl)methyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylpyridazine-4-carboxamide; 5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-isopropyl-N,3-dimethylisoxazole-4-carboxamide; 3-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,6-dimethylisonicotinamide; 6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-5-sulfamoylbenzamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1-phenylcyclobutanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide; 7-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide; 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; 2,2-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylacetamide; N2-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methylacetamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-(3-fluorophenyl)-N-methylcyclobutanecarboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2,2-difluoro-N-methyl-2-phenylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide; (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5,6-dihydro-1,4-dioxine-2-carboxamide; (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxotetrahydrofuran-2-carboxamide; 5-chloro-N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-hydroxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-2-carboxamide; N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-methoxy-N-methyltetrahydrofuran-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-methoxybutyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(3-methoxypropyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide; N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methylcyclobutanecarboxamide; 1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyltetrahydrofuran-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyloxetane-3-carboxamide; 5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1H-pyrazole-4-carboxamide; (R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide; (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide; N-(2-amino-1-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)ethyl)-N-methyltetrahydrofuran-2-carboxamide; (R)—N-((2-(3-((5-fluorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; 3,6-dichloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N,3-dimethylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,6-tetramethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N,3-dimethylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-(thiophen-2-yl)butanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-phenylbutanamide; 2-(3-fluoro-4-methoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; 2-(3,4-dimethoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-(hydroxymethyl)phenoxy)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(3-(methylsulfonyl)phenyl)acetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-mercapto-4-methylthiazol-5-yl)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)furan-2-carboxamide; (R)—N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N-methyl-3-(methylamino)pyridazine-4-carboxamide; 3-(dimethylamino)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N-methylpyridazine-4-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide; N-((2-(3-((1H-indol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(benzo[1,2,5]thiadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; 2-(4-(dimethylamino)phenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-7-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; 3-(1H-benzoimidazol-2-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(naphthalen-2-yl)acetamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxy-3-methylphenyl)-N-methylacetamide; 2-amino-3-(benzyloxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-6-(1H-1,2,4-triazol-1-yl)nicotinamide; 2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide; N2-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide; (S)-3,3-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylchroman-2-carboxamide; 4-(3,5-dimethyl-1H-pyrazol-4-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpent-4-ynamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (S)-2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-(pyridin-4-yl)propanamide; cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methyltetrahydrofuran-2-carboxamide; 1-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropiolamide; N-((2-(3-((1H-indol-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((2-(3-(benzoxazol-6-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; 2-ethoxy-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxyphenoxy)-N-methylpropanamide; 2-(cyclopropylmethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; 2,5-diamino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpentanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2-phenoxyethoxy)propanamide; 2-cyclopropyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide; N,3,5-trimethyl-N-((2-(3-(4-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; N,3,5-trimethyl-N-((2-(3-(3-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide; 3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyloxetane-3-carboxamide; 2-(2,2-difluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-fluorobenzyloxy)propanamide; 2-(2,2,2-trifluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(prop-2-ynyloxy)propanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-((5-methylisoxazol-3-yl)methoxy)propanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(1-methylpyrrolidin-3-yloxy)propanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-hydroxyethoxy)propanamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-hydroxy-N-methylcyclopropanecarboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide; 1-cyano-N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclohexanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide; 3,3,3-trifluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide; 2,3-cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyltetrahydrofuran-2-carboxamide; (5R)-—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(hydroxymethyl)-N-methyltetrahydrofuran-2-carboxamide; N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide; N-((2-(3-(5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide; (S)—N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide; (R)—N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; (R)—N-((2-(3-((7-chlorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide; 2,3,3,3-tetrafluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropane-1,1-dicarboxamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclopropanecarboxamide; (S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide; N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide; N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,2,6-trimethylbenzamide; N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylisonicotinamide; N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide; 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 3,6-Dimethyl-isoxazolo[5,4-b]pyridine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-acetamide; 3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; 1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methyl-acetamide; 3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic acid{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; (R)-Tetrahydro-furan-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-3-cyano-2-hydroxy-6,N-dimethyl-isonicotinamide; 6-Chloro-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide; 1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,2-difluoro-N-methyl-2-phenyl-acetamide; (R)-Tetrahydro-furan-2-carboxylic acid [5-(3-benzo[1,2,5]oxadiazol-5-ylmethyl-ureido)-[1,2,4]thiadiazol-3-ylmethyl]-methyl-amide; 3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 3,5-Dimethyl-pyridazine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; 1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide; 1-Phenyl-cyclobutanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Phenyl-cyclobutanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-phenyl-acetamide; 1,1-Dioxo-tetrahydro-llambda*6*-thiophene-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,3-Dihydro-benzofuran-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; (R)-Tetrahydro-furan-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,3-Dihydro-benzofuran-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; (R)—N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide; (R)—N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide; N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide; N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide; 2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyridin-2-yl-acetamide; 1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-amide 2-({5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide); Cyclopentanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2-Methyl-cyclohexanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; Cyclohexanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Cyano-cyclopropanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 1-Hydroxy-cyclopropanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; 2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-hydroxy-2,N-dimethyl-propionamide; 1-Cyano-cyclopropanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide; N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-((S)-4-hydroxy-2-oxo-pyrrolidin-1-yl)-N-methyl-acetamide; 1,1-Dioxo-tetrahydro-116-thiophene-3-sulfonic acid {2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylbenzenesulfonamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide; N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropane-1-sulfonamide; 1-(3,4-dichlorobenzyl)-3-(4-(4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl)thiazol-2-yl)urea; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbutane-1-sulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylethanesulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanesulfonamide; N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-(methylsulfonamido)ethyl)methanesulfonamide; 1-[4-(1,1-Dioxo-116-isothiazolidin-2-ylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea; Ethanesulfonic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-4-morpholin-4-yl-benzenesulfonamide; Furan-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Thiophene-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Pyridine-3-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; Pyridine-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1-Methyl-1H-imidazole-4-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; 1,2-Dimethyl-1H-imidazole-4-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide; N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-C-pyridin-3-yl-methanesulfonamide; N-(3,5-Dimethyl-isoxazol-4-ylmethyl)-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methanesulfonamide.
 21. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt of a compound of claim
 1. 22. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 20 or a pharmaceutically acceptable salt of a compound of claim
 20. 23. The compound of claim 3, selected from the group consisting of 5-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-1-(methylsulfonyl)pyrrolidin-3-yl acetate and 1-(3-Fluoro-benzyl)-3-{4-[1-(propane-1-sulfonyl)-pyrrolidin-2-yl]-thiazol-2-yl}-urea. 